(data stored in ACNUC27670 zone)

HOGENOM: HS1_PE4650

ID   HS1_PE4650                           STANDARD;      PRT;   92 AA.
AC   HS1_PE4650; P33763; Q5RHS3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A5;AltName: Full=Protein S-100D;AltName:
DE   Full=S100 calcium-binding protein A5; (HS1.PE4650).
GN   Name=S100A5; Synonyms=S100D;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4650.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A5_HUMAN
CC   -!- FUNCTION: Binds calcium, zinc and copper. One subunit can
CC       simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc
CC       ion. Calcium and copper ions compete for the same binding sites.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA79472.1; Type=Erroneous initiation;
CC       Sequence=CAA79475.1; Type=Erroneous initiation;
CC       Sequence=CAA79479.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000196420;ENST00000368718;ENSP00000357707.
DR   EMBL; BX470102; - ;
DR   EMBL; Z18949; - ;
DR   EMBL; Z18950; - ;
DR   EMBL; Z18954; - ;
DR   UniProtKB/Swiss-Prot; P33763; Q5RHS3; -.
DR   EMBL; Z18954; CAA79479.1; ALT_INIT; mRNA.
DR   EMBL; Z18949; CAA79472.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Z18950; CAA79475.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BX470102; CAI14753.1; -; Genomic_DNA.
DR   IPI; IPI00219805; -.
DR   RefSeq; NP_002953.2; NM_002962.1.
DR   UniGene; Hs.2960; -.
DR   PDB; 2KAX; NMR; -; A/B=1-92.
DR   PDB; 2KAY; NMR; -; A/B=1-92.
DR   PDBsum; 2KAX; -.
DR   PDBsum; 2KAY; -.
DR   ProteinModelPortal; P33763; -.
DR   SMR; P33763; 1-92.
DR   MINT; MINT-7256702; -.
DR   STRING; P33763; -.
DR   PhosphoSite; P33763; -.
DR   PRIDE; P33763; -.
DR   Ensembl; ENST00000359215; ENSP00000352148; ENSG00000196420.
DR   Ensembl; ENST00000368717; ENSP00000357706; ENSG00000196420.
DR   Ensembl; ENST00000368718; ENSP00000357707; ENSG00000196420.
DR   GeneID; 6276; -.
DR   KEGG; hsa:6276; -.
DR   UCSC; uc001fbx.1; human.
DR   CTD; 6276; -.
DR   GeneCards; GC01M124872; -.
DR   HGNC; HGNC:10495; S100A5.
DR   MIM; 176991; gene.
DR   neXtProt; NX_P33763; -.
DR   PharmGKB; PA34907; -.
DR   eggNOG; prNOG21159; -.
DR   GeneTree; ENSGT00600000084162; -.
DR   InParanoid; P33763; -.
DR   OrthoDB; EOG4M0F38; -.
DR   NextBio; 24361; -.
DR   ArrayExpress; P33763; -.
DR   Bgee; P33763; -.
DR   CleanEx; HS_S100A5; -.
DR   Genevestigator; P33763; -.
DR   GermOnline; ENSG00000196420; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; IDA:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IDA:UniProtKB.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; HS1.PE4650; -.
KW   ENSG000001964201755old_1320000031; ENSP000003577077901old_1320000031;
KW   BX470102; Z18949; Z18950; Z18954;
KW   3D-structure; Calcium; Complete proteome; Copper; Metal-binding;
KW   Polymorphism; Reference proteome; Repeat; Zinc.
SQ   SEQUENCE   92 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD
     KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK
//

If you have problems or comments...

PBIL Back to PBIL home page