(data stored in ACNUC27670 zone)

HOGENOM: HS1_PE4653

ID   HS1_PE4653                           STANDARD;      PRT;   101 AA.
AC   HS1_PE4653; P26447; A8K7R8; D3DV46; Q6ICP8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A4;AltName: Full=Calvasculin;AltName:
DE   Full=Metastasin;AltName: Full=Placental calcium-binding protein;AltName:
DE   Full=Protein Mts1;AltName: Full=S100 calcium-binding protein A4;
DE   (HS1.PE4653).
GN   Name=S100A4; Synonyms=CAPL, MTS1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4653.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A4_HUMAN
CC   -!- SUBUNIT: Homodimer. Interacts with PPFIBP1 in a calcium-dependent
CC       mode.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000196154;ENST00000368716;ENSP00000357705.
DR   EMBL; AK292083; - ;
DR   EMBL; BC000838; - ;
DR   EMBL; BC016300; - ;
DR   EMBL; BX470102; - ;
DR   EMBL; CH471121; - ;
DR   EMBL; CR450345; - ;
DR   EMBL; M80563; - ;
DR   EMBL; Z18950; - ;
DR   EMBL; Z33457; - ;
DR   UniProtKB/Swiss-Prot; P26447; A8K7R8; D3DV46; Q6ICP8; -.
DR   EMBL; M80563; AAA51920.1; -; mRNA.
DR   EMBL; Z18950; CAA79474.1; -; Genomic_DNA.
DR   EMBL; Z33457; CAA83880.1; -; Genomic_DNA.
DR   EMBL; CR450345; CAG29341.1; -; mRNA.
DR   EMBL; AK292083; BAF84772.1; -; mRNA.
DR   EMBL; BX470102; CAI14754.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53310.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53311.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53312.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53313.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53314.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53315.1; -; Genomic_DNA.
DR   EMBL; BC000838; AAH00838.1; -; mRNA.
DR   EMBL; BC016300; AAH16300.1; -; mRNA.
DR   IPI; IPI00032313; -.
DR   PIR; A48219; A48219.
DR   RefSeq; NP_002952.1; NM_002961.2.
DR   RefSeq; NP_062427.1; NM_019554.2.
DR   UniGene; Hs.654444; -.
DR   PDB; 1M31; NMR; -; A/B=1-101.
DR   PDB; 2Q91; X-ray; 1.63 A; A/B=1-101.
DR   PDB; 3C1V; X-ray; 1.50 A; A/B/C/D=1-101.
DR   PDB; 3CGA; X-ray; 2.03 A; A/B=1-101.
DR   PDB; 3KO0; X-ray; 2.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-101.
DR   PDB; 3M0W; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J=2-101.
DR   PDBsum; 1M31; -.
DR   PDBsum; 2Q91; -.
DR   PDBsum; 3C1V; -.
DR   PDBsum; 3CGA; -.
DR   PDBsum; 3KO0; -.
DR   PDBsum; 3M0W; -.
DR   ProteinModelPortal; P26447; -.
DR   SMR; P26447; 2-98.
DR   IntAct; P26447; 4.
DR   MINT; MINT-1372269; -.
DR   STRING; P26447; -.
DR   PhosphoSite; P26447; -.
DR   SWISS-2DPAGE; P26447; -.
DR   Cornea-2DPAGE; P26447; -.
DR   DOSAC-COBS-2DPAGE; P26447; -.
DR   PeptideAtlas; P26447; -.
DR   PRIDE; P26447; -.
DR   Ensembl; ENST00000354332; ENSP00000346294; ENSG00000196154.
DR   Ensembl; ENST00000368714; ENSP00000357703; ENSG00000196154.
DR   Ensembl; ENST00000368715; ENSP00000357704; ENSG00000196154.
DR   Ensembl; ENST00000368716; ENSP00000357705; ENSG00000196154.
DR   GeneID; 6275; -.
DR   KEGG; hsa:6275; -.
DR   UCSC; uc001fby.1; human.
DR   CTD; 6275; -.
DR   GeneCards; GC01M124879; -.
DR   H-InvDB; HIX0001081; -.
DR   HGNC; HGNC:10494; S100A4.
DR   HPA; CAB002618; -.
DR   HPA; CAB027387; -.
DR   HPA; HPA007973; -.
DR   MIM; 114210; gene.
DR   neXtProt; NX_P26447; -.
DR   PharmGKB; PA34906; -.
DR   eggNOG; prNOG20778; -.
DR   GeneTree; ENSGT00600000084162; -.
DR   InParanoid; P26447; -.
DR   OMA; NEFFEGC; -.
DR   OrthoDB; EOG4NS3D1; -.
DR   PhylomeDB; P26447; -.
DR   NextBio; 24355; -.
DR   ArrayExpress; P26447; -.
DR   Bgee; P26447; -.
DR   CleanEx; HS_S100A4; -.
DR   Genevestigator; P26447; -.
DR   GermOnline; ENSG00000196154; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR   GO; GO:0050786; F:RAGE receptor binding; IPI:UniProtKB.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; TAS:HGNC.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; HS1.PE4653; -.
KW   ENSG000001961541755old_1320000031; ENSP000003577057901old_1320000031;
KW   D3DV46_HUMAN; AK292083; BC000838; BC016300; BX470102; CH471121; CR450345;
KW   Z18950; Z33457;
KW   3D-structure; Acetylation; Calcium; Complete proteome;
KW   Direct protein sequencing; Reference proteome; Repeat.
SQ   SEQUENCE   101 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT DEAAFQKLMS
     NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK K
//

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