(data stored in ACNUC27670 zone)

HOGENOM: HS1_PE4678

ID   HS1_PE4678                           STANDARD;      PRT;   94 AA.
AC   HS1_PE4678; P23297; Q5T7Y3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A1;AltName: Full=S-100 protein alpha
DE   chain;AltName: Full=S-100 protein subunit alpha;AltName: Full=S100
DE   calcium-binding protein A1; (HS1.PE4678).
GN   Name=S100A1; Synonyms=S100A;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE4678.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A1_HUMAN
CC   -!- FUNCTION: Weakly binds calcium but binds zinc very tightly-
CC       distinct binding sites with different affinities exist for both
CC       ions on each monomer. Physiological concentrations of potassium
CC       ion antagonize the binding of both divalent cations, especially
CC       affecting high-affinity calcium-binding sites.
CC   -!- SUBUNIT: Dimer of either two alpha chains, or two beta chains, or
CC       one alpha and one beta chain. Interacts with AGER and CAPZA1 (By
CC       similarity). Interacts with FKBP4.
CC   -!- INTERACTION:
CC       Self; NbExp=4; IntAct=EBI-743686, EBI-743686;
CC       P04271:S100B; NbExp=5; IntAct=EBI-743686, EBI-458391;
CC       P25815:S100P; NbExp=7; IntAct=EBI-743686, EBI-743700;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Highly prevalent in heart. Also found in
CC       lesser quantities in skeletal muscle and brain.
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000160678;ENST00000292169;ENSP00000292169.
DR   EMBL; AB451316; - ;
DR   EMBL; AB451446; - ;
DR   EMBL; AK312152; - ;
DR   EMBL; AL162258; - ;
DR   EMBL; BC014392; - ;
DR   EMBL; BT006938; - ;
DR   EMBL; CH471121; - ;
DR   EMBL; X58079; - ;
DR   UniProtKB/Swiss-Prot; P23297; Q5T7Y3; -.
DR   EMBL; X58079; CAA41107.1; -; mRNA.
DR   EMBL; BT006938; AAP35584.1; -; mRNA.
DR   EMBL; AL162258; CAI19677.1; -; Genomic_DNA.
DR   EMBL; BC014392; AAH14392.1; -; mRNA.
DR   IPI; IPI00645016; -.
DR   PIR; A44470; BCHUIA.
DR   RefSeq; NP_006262.1; NM_006271.1.
DR   UniGene; Hs.515715; -.
DR   PDB; 2L0P; NMR; -; A/B=1-94.
DR   PDBsum; 2L0P; -.
DR   ProteinModelPortal; P23297; -.
DR   SMR; P23297; 2-94.
DR   IntAct; P23297; 7.
DR   STRING; P23297; -.
DR   PRIDE; P23297; -.
DR   Ensembl; ENST00000292169; ENSP00000292169; ENSG00000160678.
DR   Ensembl; ENST00000368698; ENSP00000357687; ENSG00000160678.
DR   GeneID; 6271; -.
DR   KEGG; hsa:6271; -.
DR   UCSC; uc001fck.1; human.
DR   CTD; 6271; -.
DR   GeneCards; GC01P124964; -.
DR   H-InvDB; HIX0199970; -.
DR   HGNC; HGNC:10486; S100A1.
DR   HPA; CAB002599; -.
DR   HPA; HPA006462; -.
DR   MIM; 176940; gene.
DR   neXtProt; NX_P23297; -.
DR   eggNOG; prNOG20611; -.
DR   InParanoid; P23297; -.
DR   OrthoDB; EOG4Z8XZ3; -.
DR   PhylomeDB; P23297; -.
DR   DrugBank; DB00768; Olopatadine.
DR   NextBio; 24339; -.
DR   ArrayExpress; P23297; -.
DR   Bgee; P23297; -.
DR   CleanEx; HS_S100A1; -.
DR   Genevestigator; P23297; -.
DR   GermOnline; ENSG00000160678; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0043234; C:protein complex; NAS:UniProtKB.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0051117; F:ATPase binding; IPI:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0048155; F:S100 alpha binding; IPI:UniProtKB.
DR   GO; GO:0048154; F:S100 beta binding; IPI:UniProtKB.
DR   GO; GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
DR   GO; GO:0008016; P:regulation of heart contraction; NAS:UniProtKB.
DR   InterPro; IPR018248; EF-hand.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF00036; efhand; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; HS1.PE4678; -.
KW   ENSG000001606781755old_1320000031; ENSP000002921697901old_1320000031;
KW   B2R5D9_HUMAN; Q5T7Y5_HUMAN; AB451316; AB451446; AK312152; AL162258;
KW   BT006938; CH471121; X58079;
KW   3D-structure; Calcium; Complete proteome; Cytoplasm; Metal-binding;
KW   Reference proteome; Repeat; Zinc.
SQ   SEQUENCE   94 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK DVDAVDKVMK
     ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS
//

If you have problems or comments...

PBIL Back to PBIL home page