(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE5563

ID   HS1_PE5563                           STANDARD;      PRT;   205 AA.
AC   HS1_PE5563; P49798;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 4; Short=RGP4; Short=RGS4;
DE   (HS1.PE5563).
GN   Name=RGS4;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE5563.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS4_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Activity on G(z)-alpha is inhibited
CC       by phosphorylation of the G-protein. Activity on G(z)-alpha and
CC       G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12.
CC   -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase (By
CC       similarity).
CC   -!- DISEASE: Genetic variation in RGS4 is associated with
CC       susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A
CC       complex, multifactorial psychotic disorder or group of disorders
CC       characterized by disturbances in the form and content of thought
CC       (e.g. delusions, hallucinations), in mood (e.g. inappropriate
CC       affect), in sense of self and relationship to the external world
CC       (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g
CC       bizarre or apparently purposeless behavior). Although it affects
CC       emotions, it is distinguished from mood disorders in which such
CC       disturbances are primary. Similarly, there may be mild impairment
CC       of cognitive function, and it is distinguished from the dementias
CC       in which disturbed cognitive function is considered primary. Some
CC       patients manifest schizophrenic as well as bipolar disorder
CC       symptoms and are often given the diagnosis of schizoaffective
CC       disorder.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000117152;ENST00000367909;ENSP00000356885.
DR   EMBL; AF493928; - ;
DR   EMBL; AK296240; - ;
DR   EMBL; AK312250; - ;
DR   EMBL; AL583850; - ;
DR   EMBL; BC000737; - ;
DR   EMBL; BC051869; - ;
DR   EMBL; BT007025; - ;
DR   EMBL; CH471067; - ;
DR   EMBL; DQ346662; - ;
DR   EMBL; DQ346663; - ;
DR   EMBL; EF054877; - ;
DR   EMBL; U27768; - ;
DR   UniProtKB/Swiss-Prot; P49798; -.
DR   EMBL; U27768; AAC50395.1; -; mRNA.
DR   EMBL; AF493928; AAM12642.1; -; mRNA.
DR   EMBL; BT007025; AAP35671.1; -; mRNA.
DR   EMBL; AL583850; CAH73767.1; -; Genomic_DNA.
DR   EMBL; BC000737; AAH00737.1; -; mRNA.
DR   EMBL; BC051869; AAH51869.1; -; mRNA.
DR   IPI; IPI00028112; -.
DR   PIR; S78221; S78221.
DR   RefSeq; NP_005604.1; NM_005613.5.
DR   UniGene; Hs.386726; -.
DR   ProteinModelPortal; P49798; -.
DR   SMR; P49798; 51-177.
DR   STRING; P49798; -.
DR   PhosphoSite; P49798; -.
DR   PRIDE; P49798; -.
DR   Ensembl; ENST00000367909; ENSP00000356885; ENSG00000117152.
DR   Ensembl; ENST00000421743; ENSP00000397181; ENSG00000117152.
DR   GeneID; 5999; -.
DR   KEGG; hsa:5999; -.
DR   UCSC; uc009wuy.1; human.
DR   CTD; 5999; -.
DR   GeneCards; GC01P134283; -.
DR   H-InvDB; HIX0001268; -.
DR   HGNC; HGNC:10000; RGS4.
DR   HPA; HPA030802; -.
DR   MIM; 181500; phenotype.
DR   MIM; 602516; gene.
DR   MIM; 604906; phenotype.
DR   neXtProt; NX_P49798; -.
DR   Orphanet; 3140; Schizophrenia.
DR   eggNOG; prNOG11248; -.
DR   GeneTree; ENSGT00600000084388; -.
DR   InParanoid; P49798; -.
DR   OrthoDB; EOG4PK297; -.
DR   PhylomeDB; P49798; -.
DR   NextBio; 23389; -.
DR   ArrayExpress; P49798; -.
DR   Bgee; P49798; -.
DR   CleanEx; HS_RGS4; -.
DR   Genevestigator; P49798; -.
DR   GermOnline; ENSG00000117152; Homo sapiens.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005516; F:calmodulin binding; TAS:ProtInc.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc.
DR   GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE5563; -.
KW   ENSG000001171521755old_1320000031; ENSP000003568857901old_1320000031;
KW   A7XA56_HUMAN; A7XA58_HUMAN; A7YVV7_HUMAN; AF493928; AK296240; AK312250;
KW   BC000737; BC051869; BT007025; CH471067; DQ346662; DQ346663; EF054877;
KW   U27768;
KW   Complete proteome; Lipoprotein; Palmitate; Phosphoprotein;
KW   Polymorphism; Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   205 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA
     ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
     VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP
     SSCGAEKQKG AKSSADCASL VPQCA
//

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