(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE5567

ID   HS1_PE5567                           STANDARD;      PRT;   181 AA.
AC   HS1_PE5567; O15539; Q53XA9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 5; Short=RGS5;
DE   (HS1.PE5567).
GN   Name=RGS5;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE5567.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS5_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,
CC       but not to G(s)-alpha (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143248;ENST00000313961;ENSP00000319308.
DR   EMBL; AB008109; - ;
DR   EMBL; AF030108; - ;
DR   EMBL; AF159570; - ;
DR   EMBL; AF493929; - ;
DR   EMBL; AJ891044; - ;
DR   EMBL; AK315357; - ;
DR   EMBL; AL451063; - ;
DR   EMBL; AL499616; - ;
DR   EMBL; AL583850; - ;
DR   EMBL; BC030059; - ;
DR   EMBL; BX537427; - ;
DR   EMBL; CH471067; - ;
DR   UniProtKB/Swiss-Prot; O15539; Q53XA9; -.
DR   EMBL; AF030108; AAB84001.1; -; mRNA.
DR   EMBL; AB008109; BAA22889.1; -; mRNA.
DR   EMBL; AF159570; AAD40957.1; -; mRNA.
DR   EMBL; AF493929; AAM12643.1; -; mRNA.
DR   EMBL; BX537427; CAD97669.1; -; mRNA.
DR   EMBL; AL451063; CAH71851.1; -; Genomic_DNA.
DR   EMBL; AL499616; CAH71851.1; JOINED; Genomic_DNA.
DR   EMBL; AL583850; CAH71851.1; JOINED; Genomic_DNA.
DR   EMBL; AL583850; CAH73764.1; -; Genomic_DNA.
DR   EMBL; AL451063; CAH73764.1; JOINED; Genomic_DNA.
DR   EMBL; AL499616; CAH73764.1; JOINED; Genomic_DNA.
DR   EMBL; AL499616; CAI15095.1; -; Genomic_DNA.
DR   EMBL; AL451063; CAI15095.1; JOINED; Genomic_DNA.
DR   EMBL; AL583850; CAI15095.1; JOINED; Genomic_DNA.
DR   EMBL; CH471067; EAW90731.1; -; Genomic_DNA.
DR   EMBL; BC030059; AAH30059.1; -; mRNA.
DR   IPI; IPI00183077; -.
DR   RefSeq; NP_003608.1; NM_003617.3.
DR   UniGene; Hs.24950; -.
DR   PDB; 2CRP; NMR; -; A=44-180.
DR   PDBsum; 2CRP; -.
DR   ProteinModelPortal; O15539; -.
DR   SMR; O15539; 44-180.
DR   STRING; O15539; -.
DR   PhosphoSite; O15539; -.
DR   PRIDE; O15539; -.
DR   Ensembl; ENST00000313961; ENSP00000319308; ENSG00000143248.
DR   GeneID; 8490; -.
DR   KEGG; hsa:8490; -.
DR   UCSC; uc001gcn.1; human.
DR   CTD; 8490; -.
DR   GeneCards; GC01M134357; -.
DR   H-InvDB; HIX0001269; -.
DR   HGNC; HGNC:10001; RGS5.
DR   HPA; HPA001821; -.
DR   MIM; 603276; gene.
DR   neXtProt; NX_O15539; -.
DR   PharmGKB; PA34376; -.
DR   eggNOG; prNOG09689; -.
DR   OrthoDB; EOG41RPW5; -.
DR   PhylomeDB; O15539; -.
DR   NextBio; 31763; -.
DR   ArrayExpress; O15539; -.
DR   Bgee; O15539; -.
DR   CleanEx; HS_RGS5; -.
DR   Genevestigator; O15539; -.
DR   GermOnline; ENSG00000143248; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE5567; -.
KW   ENSG000001432481755old_1320000031; ENSP000003193087901old_1320000031;
KW   B2RD05_HUMAN; Q599J0_HUMAN; AB008109; AF030108; AF159570; AF493929;
KW   AK315357; AL451063; AL499616; AL583850; BC030059; BX537427; CH471067;
KW   3D-structure; Complete proteome; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   181 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ
     WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF
     IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI
     K
//

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