(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE5991

ID   HS1_PE5991                           STANDARD;      PRT;   202 AA.
AC   HS1_PE5991; O15492; B2R4M4; Q5VYN9; Q99701;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 16; Short=RGS16;AltName:
DE   Full=A28-RGS14P;AltName: Full=Retinal-specific RGS; Short=RGS-r;
DE   Short=hRGS-r;AltName: Full=Retinally abundant regulator of G-protein
DE   signaling; (HS1.PE5991).
GN   Name=RGS16; Synonyms=RGSR;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE5991.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS16_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,
CC       but not to G(s)-alpha. May play a role in regulating the kinetics
CC       of signaling in the phototransduction cascade.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in retina with lower
CC       levels of expression in most other tissues.
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12 (By similarity).
CC   -!- PTM: Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced
CC       GTPase accelerating (GAP) activity on G(i)-alpha.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143333;ENST00000367558;ENSP00000356529.
DR   EMBL; AF009356; - ;
DR   EMBL; AF493937; - ;
DR   EMBL; AK311880; - ;
DR   EMBL; AL353778; - ;
DR   EMBL; BC006243; - ;
DR   EMBL; BT006638; - ;
DR   EMBL; CH471067; - ;
DR   EMBL; U70426; - ;
DR   EMBL; U94829; - ;
DR   UniProtKB/Swiss-Prot; O15492; B2R4M4; Q5VYN9; Q99701; -.
DR   EMBL; U70426; AAC16912.1; -; mRNA.
DR   EMBL; U94829; AAC52040.1; -; mRNA.
DR   EMBL; AF009356; AAC39642.1; -; Genomic_DNA.
DR   EMBL; AF493937; AAM12651.1; -; mRNA.
DR   EMBL; BT006638; AAP35284.1; -; mRNA.
DR   EMBL; AK311880; BAG34821.1; -; mRNA.
DR   EMBL; AL353778; CAH72419.1; -; Genomic_DNA.
DR   EMBL; CH471067; EAW91129.1; -; Genomic_DNA.
DR   EMBL; BC006243; AAH06243.1; -; mRNA.
DR   IPI; IPI00289948; -.
DR   RefSeq; NP_002919.3; NM_002928.3.
DR   UniGene; Hs.413297; -.
DR   PDB; 2BT2; X-ray; 1.90 A; A/B/C/D/E=53-190.
DR   PDB; 2IK8; X-ray; 2.71 A; B/D=53-190.
DR   PDBsum; 2BT2; -.
DR   PDBsum; 2IK8; -.
DR   ProteinModelPortal; O15492; -.
DR   SMR; O15492; 6-188.
DR   STRING; O15492; -.
DR   PhosphoSite; O15492; -.
DR   PRIDE; O15492; -.
DR   Ensembl; ENST00000367558; ENSP00000356529; ENSG00000143333.
DR   GeneID; 6004; -.
DR   KEGG; hsa:6004; -.
DR   CTD; 6004; -.
DR   GeneCards; GC01M153804; -.
DR   H-InvDB; HIX0001402; -.
DR   HGNC; HGNC:9997; RGS16.
DR   MIM; 602514; gene.
DR   neXtProt; NX_O15492; -.
DR   PharmGKB; PA34367; -.
DR   eggNOG; prNOG19939; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; O15492; -.
DR   OMA; PAEPSHT; -.
DR   OrthoDB; EOG4STS5S; -.
DR   NextBio; 23419; -.
DR   ArrayExpress; O15492; -.
DR   Bgee; O15492; -.
DR   CleanEx; HS_RGS16; -.
DR   Genevestigator; O15492; -.
DR   GermOnline; ENSG00000143333; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005516; F:calmodulin binding; TAS:ProtInc.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
DR   GO; GO:0007601; P:visual perception; TAS:ProtInc.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE5991; -.
KW   ENSG000001433331755old_1320000031; ENSP000003565297901old_1320000031;
KW   AF009356; AF493937; AK311880; AL353778; BC006243; BT006638; CH471067;
KW   U94829;
KW   3D-structure; Complete proteome; Lipoprotein; Palmitate;
KW   Phosphoprotein; Polymorphism; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   202 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL
     GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE
     FICSEAPKEV NIDHETHELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL
     AAQASAASAT LSSCSLDEPS HT
//

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