(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE6104

ID   HS1_PE6104                           STANDARD;      PRT;   235 AA.
AC   HS1_PE6104; Q9NS28; B2RD23;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 18; Short=RGS18;
DE   (HS1.PE6104).
GN   Name=RGS18; Synonyms=RGS13;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6104.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS18_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-
CC       2, G(i) alpha-3 and G(q) alpha.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in peripheral leukocytes, bone
CC       marrow, platelet, spleen and fetal liver.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000150681;ENST00000367460;ENSP00000356430.
DR   EMBL; AF076642; - ;
DR   EMBL; AF268036; - ;
DR   EMBL; AK057114; - ;
DR   EMBL; AK292015; - ;
DR   EMBL; AK315377; - ;
DR   EMBL; AL513175; - ;
DR   EMBL; AL596342; - ;
DR   EMBL; BC020632; - ;
DR   EMBL; CH471067; - ;
DR   UniProtKB/Swiss-Prot; Q9NS28; B2RD23; -.
DR   EMBL; AF076642; AAF80227.1; -; mRNA.
DR   EMBL; AF268036; AAK58589.1; -; mRNA.
DR   EMBL; AL596342; CAH71160.1; -; Genomic_DNA.
DR   EMBL; AL513175; CAH71160.1; JOINED; Genomic_DNA.
DR   EMBL; AK315377; BAG37770.1; -; mRNA.
DR   EMBL; AL513175; CAH70529.1; -; Genomic_DNA.
DR   EMBL; AL596342; CAH70529.1; JOINED; Genomic_DNA.
DR   EMBL; CH471067; EAW91223.1; -; Genomic_DNA.
DR   EMBL; BC020632; AAH20632.1; -; mRNA.
DR   IPI; IPI00016825; -.
DR   RefSeq; NP_570138.1; NM_130782.2.
DR   UniGene; Hs.440890; -.
DR   PDB; 2DLV; NMR; -; A=76-202.
DR   PDB; 2JM5; NMR; -; A=75-223.
DR   PDB; 2OWI; NMR; -; A=75-223.
DR   PDBsum; 2DLV; -.
DR   PDBsum; 2JM5; -.
DR   PDBsum; 2OWI; -.
DR   ProteinModelPortal; Q9NS28; -.
DR   SMR; Q9NS28; 77-204.
DR   STRING; Q9NS28; -.
DR   PhosphoSite; Q9NS28; -.
DR   OGP; Q9NS28; -.
DR   PRIDE; Q9NS28; -.
DR   Ensembl; ENST00000367460; ENSP00000356430; ENSG00000150681.
DR   GeneID; 64407; -.
DR   KEGG; hsa:64407; -.
DR   UCSC; uc001gsg.1; human.
DR   CTD; 64407; -.
DR   GeneCards; GC01P163363; -.
DR   H-InvDB; HIX0001430; -.
DR   HGNC; HGNC:14261; RGS18.
DR   MIM; 607192; gene.
DR   neXtProt; NX_Q9NS28; -.
DR   PharmGKB; PA34369; -.
DR   eggNOG; prNOG09430; -.
DR   GeneTree; ENSGT00600000084388; -.
DR   InParanoid; Q9NS28; -.
DR   OMA; EVNLDFH; -.
DR   OrthoDB; EOG42BX9H; -.
DR   PhylomeDB; Q9NS28; -.
DR   NextBio; 66362; -.
DR   ArrayExpress; Q9NS28; -.
DR   Bgee; Q9NS28; -.
DR   CleanEx; HS_RGS13; -.
DR   CleanEx; HS_RGS18; -.
DR   Genevestigator; Q9NS28; -.
DR   GermOnline; ENSG00000150681; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE6104; -.
KW   ENSG000001506811755old_1320000031; ENSP000003564307901old_1320000031;
KW   A8K7K0_HUMAN; B3KQ04_HUMAN; AF076642; AF268036; AK057114; AK292015;
KW   AL513175; AL596342; BC020632; CH471067;
KW   3D-structure; Complete proteome; Cytoplasm; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   235 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL LVQKPEFHED
     TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF TRFLKTEFSE ENIEFWIACE
     DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE VNLDFHTKEV ITNSITQPTL HSFDAAQSRV
     YQLMEQDSYT RFLKSDIYLD LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL
//

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