(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE6106

ID   HS1_PE6106                           STANDARD;      PRT;   209 AA.
AC   HS1_PE6106; Q08116; B2RDM9; B4DZY0; Q07918; Q9H1W2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 1; Short=RGS1;AltName:
DE   Full=B-cell activation protein BL34;AltName: Full=Early response protein
DE   1R20; (HS1.PE6106).
GN   Name=RGS1; Synonyms=1R20, BL34, IER1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6106.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS1_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. This protein may be involved in the
CC       regulation of B-cell activation and proliferation.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q08116-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q08116-2; Sequence=VSP_036422;
CC   -!- TISSUE SPECIFICITY: B-cell specific. Expression is relatively low
CC       in B-cells and chronic lymphocytic leukemia B-cells; however, in
CC       other types of malignant B-cell such as non-Hodgkin lymphoma and
CC       hairy cell leukemia, expression is constitutively high.
CC   -!- INDUCTION: In response to several B-cell activation signals.
CC   -!- PTM: Could be phosphorylated. Might be functionally regulated by
CC       protein kinase(s).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB26289.1; Type=Erroneous initiation;
CC       Sequence=AAH15510.1; Type=Erroneous initiation;
CC       Sequence=BAG37976.1; Type=Erroneous initiation;
CC       Sequence=BAG64242.1; Type=Erroneous initiation;
CC       Sequence=CAA51826.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000090104;ENST00000367459;ENSP00000356429.
DR   EMBL; AF493925; - ;
DR   EMBL; AK303138; - ;
DR   EMBL; AK315607; - ;
DR   EMBL; AL136987; - ;
DR   EMBL; BC015510; - ;
DR   EMBL; BT006668; - ;
DR   EMBL; S59049; - ;
DR   EMBL; X73427; - ;
DR   UniProtKB/Swiss-Prot; Q08116; B2RDM9; B4DZY0; Q07918; Q9H1W2; -.
DR   EMBL; AK303138; BAG64242.1; ALT_INIT; mRNA.
DR   EMBL; AK315607; BAG37976.1; ALT_INIT; mRNA.
DR   EMBL; AL136987; CAC19805.1; -; Genomic_DNA.
DR   EMBL; BC015510; AAH15510.1; ALT_INIT; mRNA.
DR   EMBL; S59049; AAB26289.1; ALT_INIT; mRNA.
DR   EMBL; X73427; CAA51826.1; ALT_INIT; mRNA.
DR   EMBL; AF493925; AAM12639.1; -; mRNA.
DR   EMBL; BT006668; AAP35314.1; -; mRNA.
DR   IPI; IPI00873849; -.
DR   IPI; IPI00908845; -.
DR   PIR; S43436; S43436.
DR   RefSeq; NP_002913.3; NM_002922.3.
DR   UniGene; Hs.75256; -.
DR   PDB; 2BV1; X-ray; 2.00 A; A/B=63-205.
DR   PDB; 2GTP; X-ray; 2.55 A; C/D=63-205.
DR   PDBsum; 2BV1; -.
DR   PDBsum; 2GTP; -.
DR   ProteinModelPortal; Q08116; -.
DR   SMR; Q08116; 71-204.
DR   IntAct; Q08116; 4.
DR   MINT; MINT-1367963; -.
DR   STRING; Q08116; -.
DR   PRIDE; Q08116; -.
DR   Ensembl; ENST00000367459; ENSP00000356429; ENSG00000090104.
DR   GeneID; 5996; -.
DR   KEGG; hsa:5996; -.
DR   UCSC; uc001gsi.1; human.
DR   CTD; 5996; -.
DR   GeneCards; GC01P163781; -.
DR   H-InvDB; HIX0001431; -.
DR   HGNC; HGNC:9991; RGS1.
DR   MIM; 600323; gene.
DR   neXtProt; NX_Q08116; -.
DR   PharmGKB; PA34361; -.
DR   eggNOG; prNOG15027; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q08116; -.
DR   OMA; KIYKAFV; -.
DR   OrthoDB; EOG42822Z; -.
DR   NextBio; 23367; -.
DR   ArrayExpress; Q08116; -.
DR   Bgee; Q08116; -.
DR   CleanEx; HS_RGS1; -.
DR   Genevestigator; Q08116; -.
DR   GermOnline; ENSG00000090104; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005516; F:calmodulin binding; TAS:ProtInc.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   GO; GO:0007193; P:inhibition of adenylate cyclase activity by G-protein signaling pathway; TAS:ProtInc.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE6106; -.
KW   ENSG000000901041755old_1320000031; ENSP000003564297901old_1320000031;
KW   AF493925; AK303138; AK315607; AL136987; BC015510; BT006668; S59049;
KW   X73427;
KW   3D-structure; Alternative splicing; Complete proteome; Phosphoprotein;
KW   Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   209 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRAAAISTPK LDKMPGMFFS ANPKELKGTT HSLLDDKMQK RRPKTFGMDM KAYLRSMIPH
     LESGMKSSKS KDVLSAAEVM QWSQSLEKLL ANQTGQNVFG SFLKSEFSEE NIEFWLACED
     YKKTESDLLP CKAEEIYKAF VHSDAAKQIN IDFRTRESTA KKIKAPTPTC FDEAQKVIYT
     LMEKDSYPRF LKSDIYLNLL NDLQANSLK
//

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