(data stored in ACNUC17492 zone)

HOGENOM: HS1_PE6108

ID   HS1_PE6108                           STANDARD;      PRT;   211 AA.
AC   HS1_PE6108; P41220; Q6I9U5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 2; Short=RGS2;AltName:
DE   Full=Cell growth-inhibiting gene 31 protein;AltName: Full=G0/G1 switch
DE   regulatory protein 8; (HS1.PE6108).
GN   Name=RGS2; Synonyms=G0S8; ORFNames=GIG31;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6108.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS2_HUMAN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. May play a role in leukemogenesis.
CC       Plays a role in negative feedback control pathway for adenylyl
CC       cyclase signaling. Binds EIF2B5 and blocks its activity, thereby
CC       inhibiting the translation of mRNA into protein.
CC   -!- SUBUNIT: Interacts with EIF2B5.
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane. Cytoplasm.
CC       Nucleus, nucleolus.
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Cell membrane. Cytoplasm.
CC       Nucleus, nucleolus.
CC   -!- SUBCELLULAR LOCATION: Isoform 3: Cell membrane. Cytoplasm.
CC       Nucleus, nucleolus.
CC   -!- SUBCELLULAR LOCATION: Isoform 4: Cell membrane. Mitochondrion.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=4;
CC       Name=1;
CC         IsoId=P41220-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P41220-2; Sequence=VSP_041296;
CC       Name=3;
CC         IsoId=P41220-3; Sequence=VSP_041297;
CC         Note=Lacks type V adenylyl cyclase (AC) inhibitory function;
CC       Name=4;
CC         IsoId=P41220-4; Sequence=VSP_041298;
CC         Note=Lacks type V adenylyl cyclase (AC) inhibitory function;
CC   -!- TISSUE SPECIFICITY: Expressed in acute myelogenous leukemia (AML)
CC       and in acute lymphoblastic leukemia (ALL).
CC   -!- PTM: Phosphorylated by protein kinase C.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000116741;ENST00000235382;ENSP00000235382.
DR   EMBL; AF493926; - ;
DR   EMBL; AK313668; - ;
DR   EMBL; AL035407; - ;
DR   EMBL; AY971351; - ;
DR   EMBL; BC007049; - ;
DR   EMBL; BC042755; - ;
DR   EMBL; BT007065; - ;
DR   EMBL; CH471067; - ;
DR   EMBL; CR457410; - ;
DR   EMBL; L13391; - ;
DR   EMBL; L13463; - ;
DR   UniProtKB/Swiss-Prot; P41220; Q6I9U5; -.
DR   EMBL; L13391; AAA20680.1; -; Genomic_DNA.
DR   EMBL; L13463; AAC37587.1; -; mRNA.
DR   EMBL; AF493926; AAM12640.1; -; mRNA.
DR   EMBL; AY971351; AAY40361.1; -; mRNA.
DR   EMBL; AK313668; BAG36420.1; -; mRNA.
DR   EMBL; BT007065; AAP35728.1; -; mRNA.
DR   EMBL; CR457410; CAG33691.1; -; mRNA.
DR   EMBL; AL035407; CAB62512.1; -; Genomic_DNA.
DR   EMBL; CH471067; EAW91231.1; -; Genomic_DNA.
DR   EMBL; BC007049; AAH07049.1; -; mRNA.
DR   IPI; IPI00013177; -.
DR   IPI; IPI01017891; -.
DR   IPI; IPI01017975; -.
DR   IPI; IPI01018248; -.
DR   PIR; I53020; I53020.
DR   RefSeq; NP_002914.1; NM_002923.3.
DR   UniGene; Hs.78944; -.
DR   PDB; 2AF0; X-ray; 2.30 A; A=71-203.
DR   PDB; 2V4Z; X-ray; 2.80 A; B=71-209.
DR   PDBsum; 2AF0; -.
DR   PDBsum; 2V4Z; -.
DR   ProteinModelPortal; P41220; -.
DR   SMR; P41220; 70-203.
DR   IntAct; P41220; 16.
DR   MINT; MINT-1380095; -.
DR   STRING; P41220; -.
DR   PhosphoSite; P41220; -.
DR   PRIDE; P41220; -.
DR   Ensembl; ENST00000235382; ENSP00000235382; ENSG00000116741.
DR   GeneID; 5997; -.
DR   KEGG; hsa:5997; -.
DR   UCSC; uc001gsl.1; human.
DR   CTD; 5997; -.
DR   GeneCards; GC01P164013; -.
DR   H-InvDB; HIX0001433; -.
DR   HGNC; HGNC:9998; RGS2.
DR   MIM; 600861; gene.
DR   neXtProt; NX_P41220; -.
DR   PharmGKB; PA34372; -.
DR   eggNOG; prNOG10240; -.
DR   InParanoid; P41220; -.
DR   OMA; AKKIYTD; -.
DR   OrthoDB; EOG4ZGPD8; -.
DR   PhylomeDB; P41220; -.
DR   NextBio; 23371; -.
DR   ArrayExpress; P41220; -.
DR   Bgee; P41220; -.
DR   CleanEx; HS_RGS2; -.
DR   Genevestigator; P41220; -.
DR   GermOnline; ENSG00000116741; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; ISS:BHF-UCL.
DR   GO; GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; TAS:ProtInc.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; ISS:BHF-UCL.
DR   GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:BHF-UCL.
DR   GO; GO:0010519; P:negative regulation of phospholipase activity; ISS:BHF-UCL.
DR   GO; GO:0060452; P:positive regulation of cardiac muscle contraction; ISS:BHF-UCL.
DR   GO; GO:0071877; P:regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0055119; P:relaxation of cardiac muscle; ISS:BHF-UCL.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; HS1.PE6108; -.
KW   ENSG000001167411755old_1320000031; ENSP000002353827901old_1320000031;
KW   Q49A86_HUMAN; AF493926; AK313668; AL035407; AY971351; BC007049; BC042755;
KW   CH471067; CR457410; L13391; L13463;
KW   3D-structure; Alternative initiation; Cell cycle; Cell membrane;
KW   Complete proteome; Cytoplasm; Membrane; Mitochondrion; Nucleus;
KW   Phosphoprotein; Reference proteome; Signal transduction inhibitor;
KW   Translation regulation.
SQ   SEQUENCE   211 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT
     GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
     KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL
     MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
//

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