(data stored in ACNUC10083 zone)

HOGENOM: HS1_PE648

ID   HS1_PE648                            STANDARD;      PRT;   869 AA.
AC   HS1_PE648;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride transport protein 6;AltName: Full=Chloride channel
DE   protein 6; Short=ClC-6; (HS1.PE648).
GN   Name=CLCN6; Synonyms=KIAA0046;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE648.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN6_HUMAN
CC   -!- FUNCTION: Chloride transport protein, initially identified as
CC       voltage-gated chloride channel. The presence of the conserved
CC       gating glutamate residues suggests that is functions as
CC       antiporter.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane
CC       protein. Note=Detected in detergent-resistant lipid rafts.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=A; Synonyms=Clc-6a;
CC         IsoId=P51797-1; Sequence=Displayed;
CC       Name=B; Synonyms=ClC-6b, D2-A1;
CC         IsoId=P51797-2; Sequence=VSP_001043, VSP_001044;
CC       Name=C; Synonyms=ClC-6c, D1-A1;
CC         IsoId=P51797-3; Sequence=VSP_001045, VSP_001046;
CC       Name=D; Synonyms=ClC-6d, D1-A2;
CC         IsoId=P51797-4; Sequence=VSP_001047, VSP_001048;
CC       Name=E;
CC         IsoId=P51797-5; Sequence=VSP_017188;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Testis, ovary, small intestine, brain and
CC       skeletal muscle. Low level expression in aortic and coronary
CC       vascular smooth muscle cells, and aortic endothelial cells.
CC       Isoform C is only detected in kidney.
CC   -!- PTM: N-glycosylated on several asparagine residues.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The presence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as antiporters (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-6/CLCN6 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231081 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000011021;ENST00000346436;ENSP00000234488.
DR   EMBL; AF009247; - ;
DR   EMBL; AF009248; - ;
DR   EMBL; AF009249; - ;
DR   EMBL; AF009250; - ;
DR   EMBL; AF009251; - ;
DR   EMBL; AF009252; - ;
DR   EMBL; AF009253; - ;
DR   EMBL; AF009254; - ;
DR   EMBL; AF009255; - ;
DR   EMBL; AF009256; - ;
DR   EMBL; AF009257; - ;
DR   EMBL; AF398930; - ;
DR   EMBL; AK289999; - ;
DR   EMBL; AK294764; - ;
DR   EMBL; AL021155; - ;
DR   EMBL; AL953897; - ;
DR   EMBL; BC117420; - ;
DR   EMBL; BC117424; - ;
DR   EMBL; CH471130; - ;
DR   EMBL; D28475; - ;
DR   EMBL; X83378; - ;
DR   EMBL; X96391; - ;
DR   EMBL; X99472; - ;
DR   EMBL; X99473; - ;
DR   EMBL; X99474; - ;
DR   EMBL; X99475; - ;
DR   UniProtKB/Swiss-Prot; P51797; A8K1T4; O60818; O60819; O60820; O60821; P78520; P78521; -.
DR   UniProtKB/Swiss-Prot; Q17R81; Q5SNW2; Q5SNW3; Q5SNX1; Q5SNX2; Q5SNX3; Q99427; Q99428; -.
DR   UniProtKB/Swiss-Prot; Q99429; -.
DR   EMBL; X83378; CAA58292.1; -; mRNA.
DR   EMBL; X96391; CAA65255.1; -; mRNA.
DR   EMBL; X99472; CAA67835.1; -; Genomic_DNA.
DR   EMBL; X99473; CAA67836.1; -; mRNA.
DR   EMBL; X99474; CAA67837.1; -; mRNA.
DR   EMBL; X99475; CAA67838.1; -; mRNA.
DR   EMBL; AF009257; AAB69287.1; -; Genomic_DNA.
DR   EMBL; AF009247; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009248; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009249; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009250; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009251; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009252; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009253; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009254; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009255; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; AF009256; AAB69287.1; JOINED; Genomic_DNA.
DR   EMBL; D28475; BAA05836.4; -; mRNA.
DR   EMBL; AK289999; BAF82688.1; -; mRNA.
DR   EMBL; AL953897; CAI15891.1; -; Genomic_DNA.
DR   EMBL; AL021155; CAI15891.1; JOINED; Genomic_DNA.
DR   EMBL; AL953897; CAI15892.1; -; Genomic_DNA.
DR   EMBL; AL021155; CAI15892.1; JOINED; Genomic_DNA.
DR   EMBL; AL953897; CAI15893.1; -; Genomic_DNA.
DR   EMBL; AL021155; CAI15893.1; JOINED; Genomic_DNA.
DR   EMBL; AL953897; CAI15894.1; -; Genomic_DNA.
DR   EMBL; AL021155; CAI15894.1; JOINED; Genomic_DNA.
DR   EMBL; AL953897; CAI15895.1; -; Genomic_DNA.
DR   EMBL; AL021155; CAI15895.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; CAI23402.1; -; Genomic_DNA.
DR   EMBL; AL953897; CAI23402.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; CAI23403.1; -; Genomic_DNA.
DR   EMBL; AL953897; CAI23403.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; CAI23404.1; -; Genomic_DNA.
DR   EMBL; AL953897; CAI23404.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; CAI23405.1; -; Genomic_DNA.
DR   EMBL; AL953897; CAI23405.1; JOINED; Genomic_DNA.
DR   EMBL; AL021155; CAI23406.1; -; Genomic_DNA.
DR   EMBL; AL953897; CAI23406.1; JOINED; Genomic_DNA.
DR   EMBL; CH471130; EAW71715.1; -; Genomic_DNA.
DR   EMBL; BC117420; AAI17421.1; -; mRNA.
DR   EMBL; BC117424; AAI17425.1; -; mRNA.
DR   IPI; IPI00180121; -.
DR   IPI; IPI00305252; -.
DR   IPI; IPI00395741; -.
DR   IPI; IPI00414669; -.
DR   IPI; IPI00642888; -.
DR   PIR; S68428; S68428.
DR   RefSeq; NP_001277.1; NM_001286.2.
DR   RefSeq; NP_068503.1; NM_021735.2.
DR   RefSeq; NP_068504.1; NM_021736.2.
DR   RefSeq; NP_068505.1; NM_021737.2.
DR   UniGene; Hs.193043; -.
DR   ProteinModelPortal; P51797; -.
DR   SMR; P51797; 803-864.
DR   STRING; P51797; -.
DR   PhosphoSite; P51797; -.
DR   PRIDE; P51797; -.
DR   Ensembl; ENST00000346436; ENSP00000234488; ENSG00000011021.
DR   GeneID; 1185; -.
DR   KEGG; hsa:1185; -.
DR   UCSC; uc001ate.2; human.
DR   UCSC; uc009vnf.1; human.
DR   UCSC; uc009vng.1; human.
DR   UCSC; uc009vnh.1; human.
DR   CTD; 1185; -.
DR   GeneCards; GC01P011021; -.
DR   H-InvDB; HIX0000129; -.
DR   HGNC; HGNC:2024; CLCN6.
DR   HPA; HPA032097; -.
DR   MIM; 602726; gene.
DR   neXtProt; NX_P51797; -.
DR   PharmGKB; PA26551; -.
DR   eggNOG; prNOG17595; -.
DR   OMA; PDIHDLD; -.
DR   OrthoDB; EOG4N5VW7; -.
DR   NextBio; 4898; -.
DR   ArrayExpress; P51797; -.
DR   Bgee; P51797; -.
DR   Genevestigator; P51797; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; NAS:UniProtKB.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; NAS:UniProtKB.
DR   GO; GO:0006884; P:cell volume homeostasis; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002248; Cl_channel-6.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01117; CLCHANNEL6.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; HS1.PE648; -.
KW   ENSG000000110211755old_1320000031; ENSP000002344887901old_1320000031;
KW   B4DGT7_HUMAN; Q8IZX0_HUMAN; AF009247; AF009248; AF009249; AF009250;
KW   AF009252; AF009253; AF009254; AF009255; AF009256; AF009257; AF398930;
KW   AK294764; AL021155; AL953897; BC117420; BC117424; CH471130; D28475;
KW   X96391; X99472; X99473; X99474; X99475;
KW   Alternative splicing; Antiport; ATP-binding; CBS domain; Chloride;
KW   Complete proteome; Endosome; Glycoprotein; Ion transport; Membrane;
KW   Nucleotide-binding; Polymorphism; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   869 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP
     YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC
     SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL
     LCKVLGVLFS VAGGLFVEKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD
     FVSAGAAAGV AAAFGAPIGG TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF
     GSWGSFQLPG LLNFGEFKCS DSDKKCHLWT AMDLGFFVVM GVIGGLLGAT FNCLNKRLAK
     YRMRNVHPKP KLVRVLESLL VSLVTTVVVF VASMVLGECR QMSSSSQIGN DSFQLQVTED
     VNSSIKTFFC PNDTYNDMAT LFFNPQESAI LQLFHQDGTF SPVTLALFFV LYFLLACWTY
     GISVPSGLFV PSLLCGAAFG RLVANVLKSY IGLGHIYSGT FALIGAAAFL GGVVRMTISL
     TVILIESTNE ITYGLPIMVT LMVAKWTGDF FNKGIYDIHV GLRGVPLLEW ETEVEMDKLR
     ASDIMEPNLT YVYPHTRIQS LVSILRTTVH HAFPVVTENR GNEKEFMKGN QLISNNIKFK
     KSSILTRAGE QRKRSQSMKS YPSSELRNMC DEHIASEEPA EKEDLLQQML ERRYTPYPNL
     YPDQSPSEDW TMEERFRPLT FHGLILRSQL VTLLVRGVCY SESQSSASQP RLSYAEMAED
     YPRYPDIHDL DLTLLNPRMI VDVTPYMNPS PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA
     VGEIVGIITR HNLTYEFLQA RLRQHYQTI
//

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