(data stored in ACNUC15324 zone)

HOGENOM: HS1_PE6597

ID   HS1_PE6597                           STANDARD;      PRT;   177 AA.
AC   HS1_PE6597; Q9UHD0; Q96QR4; Q9NUA0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-19; Short=IL-19;AltName: Full=Melanoma
DE   differentiation-associated protein-like protein;AltName: Full=NG 1;Flags:
DE   Precursor; (HS1.PE6597).
GN   Name=IL19; Synonyms=ZMDA1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6597.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL19_HUMAN
CC   -!- FUNCTION: May play some important roles in inflammatory responses.
CC       Up-regulates IL-6 and TNF-alpha and induces apoptosis (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK91776.1; Type=Erroneous initiation;
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il19/";
CC   -!- GENE_FAMILY: HOG000113033 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000142224;ENST00000422924;ENSP00000395726.
DR   EMBL; AF192498; - ;
DR   EMBL; AF276915; - ;
DR   EMBL; AF390905; - ;
DR   EMBL; AF453946; - ;
DR   EMBL; AL049615; - ;
DR   EMBL; AY040367; - ;
DR   UniProtKB/Swiss-Prot; Q9UHD0; Q96QR4; Q9NUA0; -.
DR   EMBL; AF276915; AAG16755.1; -; Genomic_DNA.
DR   EMBL; AF453946; AAN40906.1; -; mRNA.
DR   EMBL; AF192498; AAF06663.1; -; mRNA.
DR   EMBL; AY040367; AAK91776.1; ALT_INIT; mRNA.
DR   EMBL; AF390905; AAK64498.1; -; Genomic_DNA.
DR   EMBL; AL049615; CAB72342.1; -; Genomic_DNA.
DR   IPI; IPI00028480; -.
DR   RefSeq; NP_037503.2; NM_013371.3.
DR   RefSeq; NP_715639.1; NM_153758.2.
DR   UniGene; Hs.661017; -.
DR   PDB; 1N1F; X-ray; 1.95 A; A=19-177.
DR   PDBsum; 1N1F; -.
DR   ProteinModelPortal; Q9UHD0; -.
DR   SMR; Q9UHD0; 22-177.
DR   STRING; Q9UHD0; -.
DR   PRIDE; Q9UHD0; -.
DR   Ensembl; ENST00000270218; ENSP00000270218; ENSG00000142224.
DR   Ensembl; ENST00000340758; ENSP00000343000; ENSG00000142224.
DR   Ensembl; ENST00000422924; ENSP00000395726; ENSG00000142224.
DR   GeneID; 29949; -.
DR   KEGG; hsa:29949; -.
DR   UCSC; uc001heo.1; human.
DR   CTD; 29949; -.
DR   GeneCards; GC01P177670; -.
DR   HGNC; HGNC:5990; IL19.
DR   MIM; 605687; gene.
DR   neXtProt; NX_Q9UHD0; -.
DR   GeneTree; ENSGT00410000025637; -.
DR   InParanoid; Q9UHD0; -.
DR   OrthoDB; EOG4XWG07; -.
DR   Pathway_Interaction_DB; il23pathway; IL23-mediated signaling events.
DR   NextBio; 52635; -.
DR   ArrayExpress; Q9UHD0; -.
DR   Bgee; Q9UHD0; -.
DR   CleanEx; HS_IL19; -.
DR   Genevestigator; Q9UHD0; -.
DR   GermOnline; ENSG00000142224; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; TAS:UniProtKB.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020421; Interleukin-19.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01934; INTRLEUKIN19.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
DR   HOGENOMDNA; HS1.PE6597; -.
KW   ENSG000001422241755old_1320000031; ENSP000003957267901old_1320000031;
KW   AF192498; AF276915; AF390905; AF453946; AL049615; AY040367;
KW   3D-structure; Apoptosis; Complete proteome; Cytokine;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism;
KW   Reference proteome; Secreted; Signal.
SQ   SEQUENCE   177 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKLQCVSLWL LGTILILCSV DNHGLRRCLI STDMHHIEES FQEIKRAIQA KDTFPNVTIL
     STLETLQIIK PLDVCCVTKN LLAFYVDRVF KDHQEPNPKI LRKISSIANS FLYMQKTLRQ
     CQEQRQCHCR QEATNATRVI HDNYDQLEVH AAAIKSLGEL DVFLAWINKN HEVMFSA
//

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