(data stored in ACNUC15324 zone)

HOGENOM: HS1_PE6598

ID   HS1_PE6598                           STANDARD;      PRT;   176 AA.
AC   HS1_PE6598; Q9NYY1; Q17RB3; Q96QZ6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-20; Short=IL-20;AltName: Full=Cytokine
DE   Zcyto10;Flags: Precursor; (HS1.PE6598).
GN   Name=IL20; Synonyms=ZCYTO10; ORFNames=UNQ852/PRO1801;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6598.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL20_HUMAN
CC   -!- FUNCTION: Cytokine that may be involved in epidermal function and
CC       psoriasis. Acts through STAT3.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed at very low levels in skin, trachea,
CC       and other tissues.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il20/";
CC   -!- GENE_FAMILY: HOG000113033 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000162891;ENST00000367098;ENSP00000356065.
DR   EMBL; AF224266; - ;
DR   EMBL; AF402002; - ;
DR   EMBL; AY358320; - ;
DR   EMBL; BC069311; - ;
DR   EMBL; BC069364; - ;
DR   EMBL; BC069398; - ;
DR   EMBL; BC069425; - ;
DR   EMBL; BC069449; - ;
DR   EMBL; BC069487; - ;
DR   EMBL; BC069523; - ;
DR   EMBL; BC069559; - ;
DR   EMBL; BC074948; - ;
DR   EMBL; BC074949; - ;
DR   EMBL; BC117386; - ;
DR   EMBL; BC117390; - ;
DR   UniProtKB/Swiss-Prot; Q9NYY1; Q17RB3; Q96QZ6; -.
DR   EMBL; AF224266; AAF36679.1; -; mRNA.
DR   EMBL; AY358320; AAQ88686.1; -; mRNA.
DR   EMBL; AF402002; AAK84423.1; -; Genomic_DNA.
DR   EMBL; BC069311; AAH69311.1; -; mRNA.
DR   EMBL; BC069364; AAH69364.1; -; mRNA.
DR   EMBL; BC069398; AAH69398.1; -; mRNA.
DR   EMBL; BC069425; AAH69425.1; -; mRNA.
DR   EMBL; BC069449; AAH69449.1; -; mRNA.
DR   EMBL; BC069487; AAH69487.1; -; mRNA.
DR   EMBL; BC069523; AAH69523.1; -; mRNA.
DR   EMBL; BC069559; AAH69559.1; -; mRNA.
DR   EMBL; BC074948; AAH74948.1; -; mRNA.
DR   EMBL; BC074949; AAH74949.1; -; mRNA.
DR   EMBL; BC117386; AAI17387.1; -; mRNA.
DR   EMBL; BC117390; AAI17391.1; -; mRNA.
DR   IPI; IPI00000048; -.
DR   RefSeq; NP_061194.2; NM_018724.3.
DR   UniGene; Hs.272373; -.
DR   ProteinModelPortal; Q9NYY1; -.
DR   SMR; Q9NYY1; 29-176.
DR   STRING; Q9NYY1; -.
DR   PRIDE; Q9NYY1; -.
DR   Ensembl; ENST00000367096; ENSP00000356063; ENSG00000162891.
DR   Ensembl; ENST00000367098; ENSP00000356065; ENSG00000162891.
DR   GeneID; 50604; -.
DR   KEGG; hsa:50604; -.
DR   UCSC; uc001her.1; human.
DR   CTD; 50604; -.
DR   GeneCards; GC01P177737; -.
DR   H-InvDB; HIX0028577; -.
DR   HGNC; HGNC:6002; IL20.
DR   HPA; CAB025802; -.
DR   MIM; 605619; gene.
DR   neXtProt; NX_Q9NYY1; -.
DR   PharmGKB; PA29817; -.
DR   eggNOG; prNOG07517; -.
DR   GeneTree; ENSGT00410000025637; -.
DR   InParanoid; Q9NYY1; -.
DR   OMA; YQTPDHH; -.
DR   OrthoDB; EOG4D26RF; -.
DR   PhylomeDB; Q9NYY1; -.
DR   NextBio; 53100; -.
DR   ArrayExpress; Q9NYY1; -.
DR   Bgee; Q9NYY1; -.
DR   CleanEx; HS_IL20; -.
DR   Genevestigator; Q9NYY1; -.
DR   GermOnline; ENSG00000162891; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0045517; F:interleukin-20 receptor binding; TAS:UniProtKB.
DR   GO; GO:0045618; P:positive regulation of keratinocyte differentiation; TAS:UniProtKB.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; TAS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020442; Interleukin-20.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01935; INTRLEUKIN20.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
DR   HOGENOMDNA; HS1.PE6598; -.
KW   ENSG000001628911755old_1320000031; ENSP000003560657901old_1320000031;
KW   AF224266; AF402002; AY358320; BC069311; BC069364; BC069398; BC069425;
KW   BC069487; BC069523; BC069559; BC074948; BC074949; BC117386; BC117390;
KW   Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Polymorphism; Reference proteome; Secreted; Signal.
SQ   SEQUENCE   176 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI
     DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK
     KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE
//

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