(data stored in ACNUC15324 zone)

HOGENOM: HS1_PE6604

ID   HS1_PE6604                           STANDARD;      PRT;   206 AA.
AC   HS1_PE6604; Q13007; Q96DB0; Q96KG4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-24; Short=IL-24;AltName: Full=Melanoma
DE   differentiation-associated gene 7 protein; Short=MDA-7;AltName:
DE   Full=Suppression of tumorigenicity 16 protein;Flags: Precursor;
DE   (HS1.PE6604).
GN   Name=IL24; Synonyms=MDA7, ST16;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE6604.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL24_HUMAN
CC   -!- FUNCTION: Has antiproliferative properties on melanoma cells and
CC       may contribute to terminal cell differentiation.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Up-regulated in melanoma cells induced to
CC       terminally differentiate.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-24 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_24";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il24/";
CC   -!- GENE_FAMILY: HOG000113033 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000162892;ENST00000294984;ENSP00000294984.
DR   EMBL; AF235005; - ;
DR   EMBL; AF276916; - ;
DR   EMBL; AY062931; - ;
DR   EMBL; BC009681; - ;
DR   EMBL; U16261; - ;
DR   UniProtKB/Swiss-Prot; Q13007; Q96DB0; Q96KG4; -.
DR   EMBL; U16261; AAA91780.1; -; mRNA.
DR   EMBL; AF276916; AAG41401.1; -; Genomic_DNA.
DR   EMBL; AF235005; AAK52589.1; -; Genomic_DNA.
DR   EMBL; AY062931; AAL34146.1; -; Genomic_DNA.
DR   EMBL; BC009681; AAH09681.1; -; mRNA.
DR   IPI; IPI00011399; -.
DR   RefSeq; NP_001172085.1; NM_001185156.1.
DR   RefSeq; NP_006841.1; NM_006850.3.
DR   UniGene; Hs.58831; -.
DR   UniGene; Hs.728324; -.
DR   ProteinModelPortal; Q13007; -.
DR   SMR; Q13007; 55-206.
DR   STRING; Q13007; -.
DR   PRIDE; Q13007; -.
DR   Ensembl; ENST00000294984; ENSP00000294984; ENSG00000162892.
DR   GeneID; 11009; -.
DR   KEGG; hsa:11009; -.
DR   NMPDR; fig|9606.3.peg.2978; -.
DR   UCSC; uc001hes.1; human.
DR   CTD; 11009; -.
DR   GeneCards; GC01P177769; -.
DR   H-InvDB; HIX0199961; -.
DR   HGNC; HGNC:11346; IL24.
DR   HPA; CAB025972; -.
DR   HPA; HPA008252; -.
DR   MIM; 604136; gene.
DR   neXtProt; NX_Q13007; -.
DR   PharmGKB; PA29825; -.
DR   eggNOG; prNOG11778; -.
DR   GeneTree; ENSGT00410000025637; -.
DR   PhylomeDB; Q13007; -.
DR   Pathway_Interaction_DB; il23pathway; IL23-mediated signaling events.
DR   NextBio; 41817; -.
DR   ArrayExpress; Q13007; -.
DR   Bgee; Q13007; -.
DR   CleanEx; HS_IL24; -.
DR   Genevestigator; Q13007; -.
DR   GermOnline; ENSG00000162892; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptosis; TAS:ProtInc.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020444; Interleukin-24.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   PRINTS; PR01937; INTRLEUKIN24.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
DR   HOGENOMDNA; HS1.PE6604; -.
KW   ENSG000001628921755old_1320000031; ENSP000002949847901old_1320000031;
KW   A8MVC0_HUMAN; AF235005; AF276916; AY062931; BC009681; U16261;
KW   Apoptosis; Complete proteome; Cytokine; Direct protein sequencing;
KW   Glycoprotein; Polymorphism; Reference proteome; Secreted; Signal.
SQ   SEQUENCE   206 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ GQEFHFGPCQ
     VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV
     FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL
     DVEAALTKAL GEVDILLTWM QKFYKL
//

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