(data stored in ACNUC30630 zone)

HOGENOM: HS1_PE88

ID   HS1_PE88                             STANDARD;      PRT;   303 AA.
AC   HS1_PE88; Q8N0Z8; B4DP76; Q5TA41;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=tRNA pseudouridine synthase-like 1; EC=5.4.99 -;AltName:
DE   Full=tRNA pseudouridylate synthase-like 1;AltName: Full=tRNA-uridine
DE   isomerase-like 1; (HS1.PE88).
GN   Name=PUSL1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS1.PE88.
CC       Homo sapiens chromosome 1 GRCh37  sequence 1..249240621 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PUSL1_HUMAN
CC   -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N0Z8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N0Z8-2; Sequence=VSP_036048;
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC       family.
CC   -!- GENE_FAMILY: HOG000248674 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000169972;ENST00000379031;ENSP00000368318.
DR   EMBL; AK075292; - ;
DR   EMBL; AK298218; - ;
DR   EMBL; AL139287; - ;
DR   EMBL; BC034304; - ;
DR   EMBL; CH471183; - ;
DR   UniProtKB/Swiss-Prot; Q8N0Z8; B4DP76; Q5TA41; -.
DR   EMBL; AK075292; BAC11527.1; -; mRNA.
DR   EMBL; AK298218; BAG60488.1; -; mRNA.
DR   EMBL; AL139287; CAI23172.1; -; Genomic_DNA.
DR   EMBL; CH471183; EAW56245.1; -; Genomic_DNA.
DR   EMBL; BC034304; AAH34304.1; -; mRNA.
DR   IPI; IPI00166125; -.
DR   IPI; IPI00915388; -.
DR   RefSeq; NP_699170.1; NM_153339.1.
DR   UniGene; Hs.400659; -.
DR   ProteinModelPortal; Q8N0Z8; -.
DR   SMR; Q8N0Z8; 11-287.
DR   STRING; Q8N0Z8; -.
DR   PhosphoSite; Q8N0Z8; -.
DR   PRIDE; Q8N0Z8; -.
DR   Ensembl; ENST00000379031; ENSP00000368318; ENSG00000169972.
DR   GeneID; 126789; -.
DR   KEGG; hsa:126789; -.
DR   NMPDR; fig|9606.3.peg.48; -.
DR   UCSC; uc001aed.1; human.
DR   CTD; 126789; -.
DR   GeneCards; GC01P000515; -.
DR   HGNC; HGNC:26914; PUSL1.
DR   HPA; HPA032057; -.
DR   neXtProt; NX_Q8N0Z8; -.
DR   PharmGKB; PA134947837; -.
DR   eggNOG; prNOG04373; -.
DR   GeneTree; ENSGT00510000048520; -.
DR   InParanoid; Q8N0Z8; -.
DR   OMA; ERNLCWA; -.
DR   OrthoDB; EOG4P5K9S; -.
DR   PhylomeDB; Q8N0Z8; -.
DR   NextBio; 81916; -.
DR   ArrayExpress; Q8N0Z8; -.
DR   Bgee; Q8N0Z8; -.
DR   CleanEx; HS_PUSL1; -.
DR   Genevestigator; Q8N0Z8; -.
DR   GermOnline; ENSG00000169972; Homo sapiens.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR   Gene3D; G3DSA:3.30.70.580; PseudoU_synth_1; 1.
DR   Gene3D; G3DSA:3.30.70.660; PseudoU_synth_1; 1.
DR   PANTHER; PTHR11142; PseudoU_synth_1; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR   HOGENOMDNA; HS1.PE88; -.
KW   ENSG000001699721755old_1320000031; ENSP000003683187901old_1320000031;
KW   AK075292; AK298218; AL139287; BC034304; CH471183;
KW   Alternative splicing; Complete proteome; Isomerase; Polymorphism;
KW   Reference proteome; tRNA processing.
SQ   SEQUENCE   303 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSAPASGSV RARYLVYFQY VGTDFNGVAA VRGTQRAVGV QNYLEEAAER LNSVEPVRFT
     ISSRTDAGVH ALSNAAHLDV QRRSGRPPFP PEVLAEALNT HLRHPAIRVL RAFRVPSDFH
     ARHAATSRTY LYRLATGCHR RDELPVFERN LCWTLPADCL DMVAMQEAAQ HLLGTHDFSA
     FQSAGSPVPS PVRTLRRVSV SPGQASPLVT PEESRKLRFW NLEFESQSFL YRQVRRMTAV
     LVAVGLGALA PAQVKTILES QDPLGKHQTR VAPAHGLFLK SVLYGNLGAA SCTLQGPQFG
     SHG
//

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