(data stored in ACNUC9543 zone)

HOGENOM: HS20_PE1192

ID   HS20_PE1192                          STANDARD;      PRT;   703 AA.
AC   HS20_PE1192; Q9H5Z1; A2RTX3; Q5THR0; Q9H4H7; Q9H6T6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Probable ATP-dependent RNA helicase DHX35; EC=3.6.4
DE   13;AltName: Full=DEAH box protein 35; (HS20.PE1192).
GN   Name=DHX35; Synonyms=C20orf15, DDX35;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS20.PE1192.
CC       Homo sapiens chromosome 20 GRCh37  sequence 1..62965520 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX35_HUMAN
CC   -!- FUNCTION: May be involved in pre-mRNA splicing.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15166.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000101452;ENST00000252011;ENSP00000252011.
DR   EMBL; AK025541; - ;
DR   EMBL; AK026412; - ;
DR   EMBL; AK296506; - ;
DR   EMBL; AK296793; - ;
DR   EMBL; AK303396; - ;
DR   EMBL; AL023803; - ;
DR   EMBL; BC132669; - ;
DR   EMBL; CH471077; - ;
DR   UniProtKB/Swiss-Prot; Q9H5Z1; A2RTX3; Q5THR0; Q9H4H7; Q9H6T6; -.
DR   EMBL; AK026412; BAB15476.1; -; mRNA.
DR   EMBL; AK025541; BAB15166.1; ALT_INIT; mRNA.
DR   EMBL; AL023803; CAI22035.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW76006.1; -; Genomic_DNA.
DR   EMBL; BC132669; AAI32670.1; -; mRNA.
DR   IPI; IPI00030288; -.
DR   RefSeq; NP_068750.2; NM_021931.3.
DR   UniGene; Hs.444520; -.
DR   ProteinModelPortal; Q9H5Z1; -.
DR   SMR; Q9H5Z1; 44-697.
DR   IntAct; Q9H5Z1; 1.
DR   PRIDE; Q9H5Z1; -.
DR   Ensembl; ENST00000252011; ENSP00000252011; ENSG00000101452.
DR   GeneID; 60625; -.
DR   KEGG; hsa:60625; -.
DR   UCSC; uc002xjh.1; human.
DR   CTD; 60625; -.
DR   GeneCards; GC20P034328; -.
DR   HGNC; HGNC:15861; DHX35.
DR   neXtProt; NX_Q9H5Z1; -.
DR   PharmGKB; PA27222; -.
DR   GeneTree; ENSGT00580000081426; -.
DR   InParanoid; Q9H5Z1; -.
DR   OMA; HILYLVE; -.
DR   PhylomeDB; Q9H5Z1; -.
DR   NextBio; 65461; -.
DR   ArrayExpress; Q9H5Z1; -.
DR   Bgee; Q9H5Z1; -.
DR   CleanEx; HS_DHX35; -.
DR   Genevestigator; Q9H5Z1; -.
DR   GermOnline; ENSG00000101452; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS20.PE1192; -.
KW   ENSG000001014521755old_1320000031; ENSP000002520117901old_1320000031;
KW   B4DKC6_HUMAN; B4DL08_HUMAN; B4E0J0_HUMAN; AK025541; AK026412; AK296506;
KW   AK303396; AL023803; BC132669; CH471077;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Polymorphism; Reference proteome;
KW   Spliceosome.
SQ   SEQUENCE   703 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAPVGPVKF WRPGTEGPGV SISEERQSLA ENSGTTVVYN PYAALSIEQQ RQKLPVFKLR
     NHILYLIENY QTVVIVGETG CGKSTQIPQY LAEAGWTAEG RVVGVTQPRR VAAVTVAGRV
     AEERGAVLGH EVGYCIRFDD CTDQLATRIK FLTDGMLVRE MMVDPLLTKY SVIMLDEAHE
     RTLYTDIAIG LLKKIQKKRG DLRLIVASAT LDADKFRDFF NQNETSDPAR DTCVILTVEG
     RTFPVDIFYL QSPVPDYIKS TVETVVKIHQ TEGDGDVLAF LTGQEEVETV VSMLIEQARA
     LARTGMKRHL RVLPMYAGLP SFEQMKVFER VSRSVRKVIV ATNVAETSIT ISGIVYVIDC
     GFVKLRAYNP RTAIECLVVV PVSQASANQR AGRGGRSRSG KCYRLYTEEA FDKLPQSTVP
     EMQRSNLAPV ILQLKALGID NVLRFHFMSP PPAQSMVQAL ELLYALGGLD KDCRLTEPLG
     MRIAEFPLNP MFAKMLLESG NFGCSQEILS IAAMMQIQNI FVVPPNQKSH AIRVHRKFAV
     EEGDHLTMLN IYEAFIKHNK DSKWCQEHFL NYKGLVRAAT VREQLKKLLV KFQVPRKSSE
     GDPDLVLRCI VSGFFANAAR FHSTGAYRTI RDDHELHIHP ASVLYAEKPP RWVIYNEVIQ
     TSKYYMRDVT AIESAWLLEL APHFYQQGTH LSLKAKRAKV QDP
//

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