(data stored in ACNUC3582 zone)

HOGENOM: HS20_PE1563

ID   HS20_PE1563                          STANDARD;      PRT;   870 AA.
AC   HS20_PE1563;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Extracellular sulfatase Sulf-2; Short=hSulf-2; EC=3.1.6
DE   -;Flags: Precursor; (HS20.PE1563).
GN   Name=SULF2; Synonyms=KIAA1247; ORFNames=UNQ559/PRO1120;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS20.PE1563.
CC       Homo sapiens chromosome 20 GRCh37  sequence 1..62965520 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SULF2_HUMAN
CC   -!- FUNCTION: Exhibits arylsulfatase activity and highly specific
CC       endoglucosamine-6-sulfatase activity. It can remove sulfate from
CC       the C-6 position of glucosamine within specific subregions of
CC       intact heparin.
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 7.0-8.0;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi
CC       apparatus, Golgi stack (By similarity). Cell surface (By
CC       similarity). Note=Also localized on the cell surface (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8IWU5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IWU5-2; Sequence=VSP_013362;
CC         Note=May be due to a competing acceptor splice site;
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in the ovary,
CC       skeletal muscle, stomach, brain, uterus, heart, kidney and
CC       placenta.
CC   -!- PTM: The conversion to 3-oxoalanine (also known as C-
CC       formylglycine, FGly), of a serine or cysteine residue in
CC       prokaryotes and of a cysteine residue in eukaryotes, is critical
CC       for catalytic activity (By similarity).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH20962.1; Type=Erroneous initiation;
CC       Sequence=BAA86561.2; Type=Erroneous initiation;
CC       Sequence=CAB61349.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000290161 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000196562;ENST00000359930;ENSP00000353007.
DR   EMBL; AB033073; - ;
DR   EMBL; AL034418; - ;
DR   EMBL; AL133001; - ;
DR   EMBL; AL354813; - ;
DR   EMBL; AY101176; - ;
DR   EMBL; AY358461; - ;
DR   EMBL; BC020962; - ;
DR   EMBL; BC090952; - ;
DR   EMBL; BC110539; - ;
DR   EMBL; CR749319; - ;
DR   UniProtKB/Swiss-Prot; Q8IWU5; E1P5U6; Q5JYE1; Q6UX86; Q96SG2; Q9H1H0; Q9UJR3; Q9ULH3; -.
DR   EMBL; AY101176; AAM76861.1; -; mRNA.
DR   EMBL; AB033073; BAA86561.2; ALT_INIT; mRNA.
DR   EMBL; AY358461; AAQ88826.1; -; mRNA.
DR   EMBL; CR749319; CAH18174.1; -; mRNA.
DR   EMBL; AL354813; CAI17943.1; -; Genomic_DNA.
DR   EMBL; AL034418; CAI17943.1; JOINED; Genomic_DNA.
DR   EMBL; AL034418; CAC17694.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL034418; CAI42143.1; -; Genomic_DNA.
DR   EMBL; AL354813; CAI42143.1; JOINED; Genomic_DNA.
DR   EMBL; CH471077; EAW75690.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75693.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75694.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75695.1; -; Genomic_DNA.
DR   EMBL; BC020962; AAH20962.1; ALT_INIT; mRNA.
DR   EMBL; BC110539; AAI10540.1; -; mRNA.
DR   EMBL; AL133001; CAB61349.1; ALT_INIT; mRNA.
DR   IPI; IPI00297252; -.
DR   IPI; IPI00555879; -.
DR   RefSeq; NP_001155313.1; NM_001161841.1.
DR   RefSeq; NP_061325.1; NM_018837.3.
DR   RefSeq; NP_940998.2; NM_198596.2.
DR   UniGene; Hs.162016; -.
DR   ProteinModelPortal; Q8IWU5; -.
DR   SMR; Q8IWU5; 281-387.
DR   IntAct; Q8IWU5; 1.
DR   STRING; Q8IWU5; -.
DR   PhosphoSite; Q8IWU5; -.
DR   PRIDE; Q8IWU5; -.
DR   Ensembl; ENST00000359930; ENSP00000353007; ENSG00000196562.
DR   Ensembl; ENST00000484875; ENSP00000418290; ENSG00000196562.
DR   GeneID; 55959; -.
DR   KEGG; hsa:55959; -.
DR   UCSC; uc002xto.1; human.
DR   UCSC; uc002xtr.1; human.
DR   CTD; 55959; -.
DR   GeneCards; GC20M043027; -.
DR   H-InvDB; HIX0015891; -.
DR   HGNC; HGNC:20392; SULF2.
DR   HPA; HPA002325; -.
DR   MIM; 610013; gene.
DR   neXtProt; NX_Q8IWU5; -.
DR   PharmGKB; PA134902131; -.
DR   GeneTree; ENSGT00400000022041; -.
DR   InParanoid; Q8IWU5; -.
DR   OMA; RENEKVD; -.
DR   OrthoDB; EOG49KFPX; -.
DR   PhylomeDB; Q8IWU5; -.
DR   NextBio; 61367; -.
DR   ArrayExpress; Q8IWU5; -.
DR   Bgee; Q8IWU5; -.
DR   CleanEx; HS_SULF2; -.
DR   Genevestigator; Q8IWU5; -.
DR   GermOnline; ENSG00000196562; Homo sapiens.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR   GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR   GO; GO:0004065; F:arylsulfatase activity; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0060348; P:bone development; ISS:BHF-UCL.
DR   GO; GO:0030201; P:heparan sulfate proteoglycan metabolic process; NAS:UniProtKB.
DR   GO; GO:0001822; P:kidney development; ISS:BHF-UCL.
DR   GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:BHF-UCL.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core.
DR   InterPro; IPR014615; Extracellular_sulfatase.
DR   InterPro; IPR000917; Sulfatase.
DR   Gene3D; G3DSA:3.40.720.10; Alk_phosphtse; 3.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF036665; Sulf1; 1.
DR   SUPFAM; SSF53649; Alkaline_phosphatase_core; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; FALSE_NEG.
DR   HOGENOMDNA; HS20.PE1563; -.
KW   ENSG000001965621755old_1320000031; ENSP000003530077901old_1320000031;
KW   B1AMP9_HUMAN; Q5BKT1_HUMAN; Q5JYE2_HUMAN; AB033073; AL034418; AL133001;
KW   AY101176; AY358461; BC020962; BC090952; BC110539; CR749319;
KW   Alternative splicing; Calcium; Complete proteome;
KW   Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Hydrolase;
KW   Metal-binding; Phosphoprotein; Polymorphism; Reference proteome;
KW   Signal.
SQ   SEQUENCE   870 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGPPSLVLCL LSATVFSLLG GSSAFLSHHR LKGRFQRDRR NIRPNIILVL TDDQDVELGS
     MQVMNKTRRI MEQGGAHFIN AFVTTPMCCP SRSSILTGKY VHNHNTYTNN ENCSSPSWQA
     QHESRTFAVY LNSTGYRTAF FGKYLNEYNG SYVPPGWKEW VGLLKNSRFY NYTLCRNGVK
     EKHGSDYSKD YLTDLITNDS VSFFRTSKKM YPHRPVLMVI SHAAPHGPED SAPQYSRLFP
     NASQHITPSY NYAPNPDKHW IMRYTGPMKP IHMEFTNMLQ RKRLQTLMSV DDSMETIYNM
     LVETGELDNT YIVYTADHGY HIGQFGLVKG KSMPYEFDIR VPFYVRGPNV EAGCLNPHIV
     LNIDLAPTIL DIAGLDIPAD MDGKSILKLL DTERPVNRFH LKKKMRVWRD SFLVERGKLL
     HKRDNDKVDA QEENFLPKYQ RVKDLCQRAE YQTACEQLGQ KWQCVEDATG KLKLHKCKGP
     MRLGGSRALS NLVPKYYGQG SEACTCDSGD YKLSLAGRRK KLFKKKYKAS YVRSRSIRSV
     AIEVDGRVYH VGLGDAAQPR NLTKRHWPGA PEDQDDKDGG DFSGTGGLPD YSAANPIKVT
     HRCYILENDT VQCDLDLYKS LQAWKDHKLH IDHEIETLQN KIKNLREVRG HLKKKRPEEC
     DCHKISYHTQ HKGRLKHRGS SLHPFRKGLQ EKDKVWLLRE QKRKKKLRKL LKRLQNNDTC
     SMPGLTCFTH DNQHWQTAPF WTLGPFCACT SANNNTYWCM RTINETHNFL FCEFATGFLE
     YFDLNTDPYQ LMNAVNTLDR DVLNQLHVQL MELRSCKGYK QCNPRTRNMD LGLKDGGSYE
     QYRQFQRRKW PEMKRPSSKS LGQLWEGWEG
//

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