(data stored in ACNUC22857 zone)

HOGENOM: HS22_PE891

ID   HS22_PE891                           STANDARD;      PRT;   949 AA.
AC   HS22_PE891; Q10567; C9JRD1; P78436; Q20WL3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AP-1 complex subunit beta-1;AltName: Full=Adapter-related
DE   protein complex 1 subunit beta-1;AltName: Full=Adaptor protein complex
DE   AP-1 subunit beta-1;AltName: Full=Beta-1-adaptin;AltName:
DE   Full=Beta-adaptin 1;AltName: Full=Clathrin assembly protein complex 1
DE   beta large chain;AltName: Full=Golgi adaptor HA1/AP1 adaptin beta
DE   subunit; (HS22.PE891).
GN   Name=AP1B1; Synonyms=ADTB1, BAM22, CLAPB2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS22.PE891.
CC       Homo sapiens chromosome 22 GRCh37  sequence 1..51244566 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AP1B1_HUMAN
CC   -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1
CC       that plays a role in protein sorting in the late-Golgi/trans-Golgi
CC       network (TGN) and/or endosomes. The AP complexes mediate both the
CC       recruitment of clathrin to membranes and the recognition of
CC       sorting signals within the cytosolic tails of transmembrane cargo
CC       molecules.
CC   -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer
CC       composed of two large adaptins (gamma-type subunit AP1G1 and beta-
CC       type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or
CC       AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or
CC       AP1S3).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle,
CC       clathrin-coated vesicle membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Note=Component of the coat surrounding the
CC       cytoplasmic face of coated vesicles located at the Golgi complex.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist;
CC       Name=A;
CC         IsoId=Q10567-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=Q10567-2; Sequence=VSP_000163;
CC       Name=C;
CC         IsoId=Q10567-3; Sequence=VSP_000163, VSP_038753;
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC   -!- GENE_FAMILY: HOG000163270 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000100280;ENST00000405198;ENSP00000384194.
DR   EMBL; AC000041; - ;
DR   EMBL; AC002059; - ;
DR   EMBL; AF379038; - ;
DR   EMBL; AF379039; - ;
DR   EMBL; AK294406; - ;
DR   EMBL; AK299613; - ;
DR   EMBL; CT841508; - ;
DR   EMBL; L13939; - ;
DR   EMBL; L48038; - ;
DR   EMBL; U36250; - ;
DR   EMBL; U36251; - ;
DR   EMBL; U36252; - ;
DR   EMBL; U36253; - ;
DR   EMBL; U36254; - ;
DR   EMBL; U36255; - ;
DR   EMBL; U36256; - ;
DR   EMBL; U36257; - ;
DR   EMBL; U36258; - ;
DR   EMBL; U36259; - ;
DR   EMBL; U36260; - ;
DR   EMBL; U36261; - ;
DR   EMBL; U36262; - ;
DR   EMBL; U36263; - ;
DR   EMBL; U36264; - ;
DR   EMBL; U36265; - ;
DR   EMBL; U36266; - ;
DR   EMBL; U36267; - ;
DR   EMBL; U36268; - ;
DR   UniProtKB/Swiss-Prot; Q10567; C9JRD1; P78436; Q20WL3; -.
DR   EMBL; L13939; AAC98702.1; -; mRNA.
DR   EMBL; CT841508; CAJ86438.1; -; mRNA.
DR   EMBL; AC000041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC002059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U36268; AAC50684.2; -; Genomic_DNA.
DR   EMBL; U36250; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36251; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36252; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36253; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36254; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36255; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36256; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36257; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36258; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36259; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36260; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36261; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36262; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36263; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36264; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36265; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36266; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; U36267; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; AF379038; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; AF379039; AAC50684.2; JOINED; Genomic_DNA.
DR   EMBL; L48038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IPI; IPI00328257; -.
DR   IPI; IPI00413947; -.
DR   IPI; IPI00940292; -.
DR   PIR; I54360; I54360.
DR   RefSeq; NP_001118.3; NM_001127.3.
DR   RefSeq; NP_663782.2; NM_145730.2.
DR   UniGene; Hs.368794; -.
DR   ProteinModelPortal; Q10567; -.
DR   SMR; Q10567; 2-583, 714-949.
DR   DIP; DIP-24207N; -.
DR   IntAct; Q10567; 14.
DR   STRING; Q10567; -.
DR   PhosphoSite; Q10567; -.
DR   PRIDE; Q10567; -.
DR   Ensembl; ENST00000357586; ENSP00000350199; ENSG00000100280.
DR   Ensembl; ENST00000405198; ENSP00000384194; ENSG00000100280.
DR   GeneID; 162; -.
DR   KEGG; hsa:162; -.
DR   UCSC; uc003afj.1; human.
DR   UCSC; uc003afk.1; human.
DR   CTD; 162; -.
DR   GeneCards; GC22M012687; -.
DR   H-InvDB; HIX0027860; -.
DR   HGNC; HGNC:554; AP1B1.
DR   MIM; 600157; gene.
DR   neXtProt; NX_Q10567; -.
DR   PharmGKB; PA24844; -.
DR   eggNOG; prNOG09855; -.
DR   GeneTree; ENSGT00530000063138; -.
DR   InParanoid; Q10567; -.
DR   OMA; PSCTDLE; -.
DR   OrthoDB; EOG4PG607; -.
DR   PhylomeDB; Q10567; -.
DR   Pathway_Interaction_DB; hnf3apathway; FOXA1 transcription factor network.
DR   Reactome; REACT_11123; Membrane Trafficking.
DR   Reactome; REACT_6185; HIV Infection.
DR   NextBio; 647; -.
DR   ArrayExpress; Q10567; -.
DR   Bgee; Q10567; -.
DR   CleanEx; HS_AP1B1; -.
DR   Genevestigator; Q10567; -.
DR   GermOnline; ENSG00000100280; Homo sapiens.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030665; C:clathrin coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR   GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0006892; P:post-Golgi vesicle-mediated transport; EXP:Reactome.
DR   GO; GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
DR   GO; GO:0016032; P:viral reproduction; TAS:Reactome.
DR   InterPro; IPR016342; AP_complex_bsu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012295; Beta2_adaptin/TATA-box-bd_C.
DR   InterPro; IPR009028; Calthrin/coatomer_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013041; Clathrin/coatomer_app_Ig-like.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR015151; Clathrin_b-adaptin_app_sub_C.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
DR   Gene3D; G3DSA:3.30.310.10; b_Adaptin_TBP_C; 1.
DR   Gene3D; G3DSA:2.60.40.1150; Clathrin_b-adaptin_app_Ig-like; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SUPFAM; SSF55711; AP2_adap_app; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   SUPFAM; SSF49348; Clath_adapt; 1.
DR   HOGENOMDNA; HS22.PE891; -.
KW   ENSG000001002801755old_1320000031; ENSP000003841947901old_1320000031;
KW   B4DG47_HUMAN; B4DS79_HUMAN; C9J1E7_HUMAN; AC000041; AC002059; AF379038;
KW   AK294406; AK299613; CT841508; L13939; L48038; U36250; U36251; U36252;
KW   U36254; U36255; U36256; U36257; U36258; U36259; U36260; U36261; U36262;
KW   U36264; U36265; U36266; U36267; U36268;
KW   Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasmic vesicle; Endocytosis; Golgi apparatus; Membrane;
KW   Phosphoprotein; Polymorphism; Protein transport; Reference proteome;
KW   Transport.
SQ   SEQUENCE   949 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
     DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE
     YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA
     VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI
     CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY
     VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
     YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK
     YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
     QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV
     VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS
     ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG
     GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK
     AVWLPAMKAK GLEISGTFTR QVGSISMDLQ LTNKALQVMT DFAIQFNRNS FGLAPATPLQ
     VHAPLSPNQT VEISLPLSTV GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK
     MDRQMFLATW KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL
     KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN
//

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