(data stored in ACNUC8465 zone)

HOGENOM: HS2_PE365

ID   HS2_PE365                            STANDARD;      PRT;   196 AA.
AC   HS2_PE365; P62745; P01121; Q5U0H6; Q7RTN5; Q7RTR9; Q9CUV7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoB;AltName: Full=Rho cDNA
DE   clone 6; Short=h6;Flags: Precursor; (HS2.PE365).
GN   Name=RHOB; Synonyms=ARH6, ARHB;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS2.PE365.
CC       Homo sapiens chromosome 2 GRCh37  sequence 1..243189373 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOB_HUMAN
CC   -!- FUNCTION: Mediates apoptosis in neoplastically transformed cells
CC       after DNA damage. Not essential for development but affects cell
CC       adhesion and growth factor signaling in transformed cells. Plays a
CC       negative role in tumorigenesis as deletion causes tumor formation.
CC       Involved in intracellular protein trafficking of a number of
CC       proteins. Targets PKN1 to endosomes and is involved in trafficking
CC       of the EGF receptor from late endosomes to lysosomes. Also
CC       required for stability and nuclear trafficking of AKT1/AKT which
CC       promotes endothelial cell survival during vascular development.
CC   -!- SUBUNIT: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts
CC       with ARGGEF3, RTKN and AKAP13.
CC   -!- INTERACTION:
CC       Q13829:TNFAIP1; NbExp=5; IntAct=EBI-602647, EBI-2505861;
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell
CC       membrane; Lipid-anchor. Nucleus. Note=Late endosomal membrane
CC       (geranylgeranylated form). Plasma membrane (farnesylated form).
CC       Also detected at the nuclear margin and in the nucleus.
CC   -!- PTM: Prenylation specifies the subcellular location of RHOB. The
CC       farnesylated form is localized to the plasma membrane while the
CC       geranylgeranylated form is localized to the endosome.
CC   -!- MISCELLANEOUS: RHOB is one of the targets of farnesyltransferase
CC       inhibitors which are currently under investigation as cancer
CC       therapeutics. These elevate the levels of geranylgeranylated RHOB
CC       and cause mislocalization, leading to apoptosis and antineoplastic
CC       effects.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/RHOBID42108ch2p24.html";
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000143878;ENST00000272233;ENSP00000272233.
DR   EMBL; AC023137; - ;
DR   EMBL; AF498971; - ;
DR   EMBL; AK124398; - ;
DR   EMBL; AK297495; - ;
DR   EMBL; AK312487; - ;
DR   EMBL; BC066954; - ;
DR   EMBL; BK001232; - ;
DR   EMBL; BK001671; - ;
DR   EMBL; BT019546; - ;
DR   EMBL; BT019547; - ;
DR   EMBL; CH471053; - ;
DR   EMBL; CR542272; - ;
DR   EMBL; M12174; - ;
DR   EMBL; X06820; - ;
DR   UniProtKB/Swiss-Prot; P62745; P01121; Q5U0H6; Q7RTN5; Q7RTR9; Q9CUV7; -.
DR   EMBL; X06820; CAA29968.1; -; mRNA.
DR   EMBL; AF498971; AAM21118.1; -; mRNA.
DR   EMBL; CR542272; CAG47068.1; -; mRNA.
DR   EMBL; BT019546; AAV38353.1; -; mRNA.
DR   EMBL; BT019547; AAV38354.1; -; mRNA.
DR   EMBL; AC023137; AAY24345.1; -; Genomic_DNA.
DR   EMBL; BC066954; AAH66954.1; -; mRNA.
DR   EMBL; M12174; AAA36565.1; -; mRNA.
DR   EMBL; BK001232; DAA01138.1; -; mRNA.
DR   EMBL; BK001671; DAA01912.1; -; Genomic_DNA.
DR   IPI; IPI00000041; -.
DR   PIR; A01372; TVHURH.
DR   RefSeq; NP_004031.1; NM_004040.2.
DR   UniGene; Hs.502876; -.
DR   PDB; 2FV8; X-ray; 1.90 A; A=4-187.
DR   PDBsum; 2FV8; -.
DR   ProteinModelPortal; P62745; -.
DR   SMR; P62745; 2-185.
DR   IntAct; P62745; 18.
DR   MINT; MINT-4824810; -.
DR   STRING; P62745; -.
DR   PhosphoSite; P62745; -.
DR   PeptideAtlas; P62745; -.
DR   PRIDE; P62745; -.
DR   Ensembl; ENST00000272233; ENSP00000272233; ENSG00000143878.
DR   GeneID; 388; -.
DR   KEGG; hsa:388; -.
DR   UCSC; uc002rdv.1; human.
DR   CTD; 388; -.
DR   GeneCards; GC02P020404; -.
DR   H-InvDB; HIX0023937; -.
DR   HGNC; HGNC:668; RHOB.
DR   HPA; CAB004560; -.
DR   MIM; 165370; gene.
DR   neXtProt; NX_P62745; -.
DR   eggNOG; maNOG05341; -.
DR   GeneTree; ENSGT00550000074256; -.
DR   InParanoid; P62745; -.
DR   OMA; DGRAMAM; -.
DR   PhylomeDB; P62745; -.
DR   Pathway_Interaction_DB; p75ntrpathway; p75(NTR)-mediated signaling.
DR   Reactome; REACT_11044; Signaling by Rho GTPases.
DR   Reactome; REACT_14797; Signaling by GPCR.
DR   Reactome; REACT_18266; Axon guidance.
DR   Reactome; REACT_604; Hemostasis.
DR   NextBio; 1615; -.
DR   ArrayExpress; P62745; -.
DR   Bgee; P62745; -.
DR   CleanEx; HS_RHOB; -.
DR   Genevestigator; P62745; -.
DR   GermOnline; ENSG00000143878; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; TAS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; TAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0030168; P:platelet activation; TAS:Reactome.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR   GO; GO:0007266; P:Rho protein signal transduction; TAS:UniProtKB.
DR   GO; GO:0006927; P:transformed cell apoptosis; ISS:UniProtKB.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; HS2.PE365; -.
KW   ENSG000001438781755old_1320000031; ENSP000002722337901old_1320000031;
KW   B2R692_HUMAN; B4DMJ8_HUMAN; AC023137; AF498971; AK124398; AK297495;
KW   BC066954; BK001232; BK001671; BT019546; BT019547; CH471053; CR542272;
KW   X06820;
KW   3D-structure; ADP-ribosylation; Angiogenesis; Apoptosis;
KW   Cell adhesion; Cell membrane; Complete proteome;
KW   Developmental protein; Differentiation; Direct protein sequencing;
KW   Endosome; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Prenylation;
KW   Protein transport; Reference proteome; Transport; Tumor suppressor.
SQ   SEQUENCE   196 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT
     AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD
     LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ
     KRYGSQNGCI NCCKVL
//

If you have problems or comments...

PBIL Back to PBIL home page