(data stored in ACNUC10243 zone)

HOGENOM: HS2_PE4289

ID   HS2_PE4289                           STANDARD;      PRT;   378 AA.
AC   HS2_PE4289; P51991; D3DPF4; Q53RW7; Q6URK5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A3; Short=hnRNP A3;
DE   (HS2.PE4289).
GN   Name=HNRNPA3; Synonyms=HNRPA3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS2.PE4289.
CC       Homo sapiens chromosome 2 GRCh37  sequence 1..243189373 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA3_HUMAN
CC   -!- FUNCTION: Plays a role in cytoplasmic trafficking of RNA. Binds to
CC       the cis-acting response element, A2RE. May be involved in pre-mRNA
CC       splicing.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Component of
CC       ribonucleosomes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P51991-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P51991-2; Sequence=VSP_011418;
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- CAUTION: An older version of this entry represented the conceptual
CC       translation of what was thought to be HNRNPA3 but which was in
CC       fact a pseudogene (HNRPA3P1/FBRNP) located on chromosome 10.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000170144;ENST00000435711;ENSP00000416340.
DR   EMBL; AC079305; - ;
DR   EMBL; AF517524; - ;
DR   EMBL; AY363225; - ;
DR   EMBL; BC080591; - ;
DR   EMBL; BC112027; - ;
DR   EMBL; BC113470; - ;
DR   EMBL; CH471058; - ;
DR   EMBL; S63912; - ;
DR   UniProtKB/Swiss-Prot; P51991; D3DPF4; Q53RW7; Q6URK5; -.
DR   EMBL; AY363225; AAQ63629.1; -; mRNA.
DR   EMBL; AC079305; AAY14709.1; -; Genomic_DNA.
DR   EMBL; CH471058; EAX11066.1; -; Genomic_DNA.
DR   EMBL; BC112027; AAI12028.1; -; mRNA.
DR   EMBL; BC113470; AAI13471.1; -; mRNA.
DR   IPI; IPI00419373; -.
DR   IPI; IPI00455134; -.
DR   PIR; I52962; I52962.
DR   RefSeq; NP_919223.1; NM_194247.2.
DR   UniGene; Hs.516539; -.
DR   ProteinModelPortal; P51991; -.
DR   SMR; P51991; 29-210.
DR   IntAct; P51991; 18.
DR   MINT; MINT-4999802; -.
DR   STRING; P51991; -.
DR   PhosphoSite; P51991; -.
DR   PRIDE; P51991; -.
DR   Ensembl; ENST00000392524; ENSP00000376309; ENSG00000170144.
DR   Ensembl; ENST00000435711; ENSP00000416340; ENSG00000170144.
DR   GeneID; 220988; -.
DR   KEGG; hsa:220988; -.
DR   UCSC; uc002ulb.1; human.
DR   CTD; 220988; -.
DR   GeneCards; GC02P169948; -.
DR   H-InvDB; HIX0002621; -.
DR   HGNC; HGNC:24941; HNRNPA3.
DR   HPA; HPA001666; -.
DR   MIM; 605372; gene.
DR   neXtProt; NX_P51991; -.
DR   PharmGKB; PA162391169; -.
DR   eggNOG; prNOG10194; -.
DR   InParanoid; P51991; -.
DR   OMA; QGHDPKE; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   PhylomeDB; P51991; -.
DR   Reactome; REACT_1675; mRNA Processing.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 91133; -.
DR   PMAP-CutDB; P51991; -.
DR   ArrayExpress; P51991; -.
DR   Bgee; P51991; -.
DR   CleanEx; HS_HNRNPA3; -.
DR   Genevestigator; P51991; -.
DR   GermOnline; ENSG00000170144; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; HS2.PE4289; -.
KW   ENSG000001701441755old_1320000031; ENSP000004163407901old_1320000031;
KW   D3DPF4_HUMAN; Q65ZQ3_HUMAN; Q66K53_HUMAN; Q8NFG3_HUMAN; AC079305;
KW   AY363225; BC080591; BC112027; BC113470; CH471058; S63912;
KW   Acetylation; Alternative splicing; Complete proteome;
KW   Direct protein sequencing; Methylation; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
SQ   SEQUENCE   378 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT
     LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG
     AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV
     DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG
     GNFGGRGGYG GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
     GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS FGGRSSGSPY
     GGGYGSGGGS GGYGSRRF
//

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