(data stored in ACNUC26462 zone)

HOGENOM: HS2_PE4700

ID   HS2_PE4700                           STANDARD;      PRT;   372 AA.
AC   HS2_PE4700; O94768;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein kinase 17B; EC=2.7.11 1;AltName:
DE   Full=DAP kinase-related apoptosis-inducing protein kinase 2;
DE   (HS2.PE4700).
GN   Name=STK17B; Synonyms=DRAK2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS2.PE4700.
CC       Homo sapiens chromosome 2 GRCh37  sequence 1..243189373 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ST17B_HUMAN
CC   -!- FUNCTION: Acts as a positive regulator of apoptosis.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with CHP causing CHP to translocate from the
CC       Golgi to the nucleus (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta, lung, pancreas.
CC       Lower levels in heart, brain, liver, skeletal muscle and kidney.
CC   -!- PTM: Autophosphorylated.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family. DAP kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000233016 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000081320;ENST00000409228;ENSP00000386853.
DR   EMBL; AB011421; - ;
DR   EMBL; AC114760; - ;
DR   EMBL; AK312865; - ;
DR   EMBL; BC016040; - ;
DR   EMBL; CH471063; - ;
DR   EMBL; CR542210; - ;
DR   EMBL; CR542225; - ;
DR   UniProtKB/Swiss-Prot; O94768; -.
DR   EMBL; AB011421; BAA34127.1; -; mRNA.
DR   EMBL; BC016040; AAH16040.1; -; mRNA.
DR   IPI; IPI00014934; -.
DR   RefSeq; NP_004217.1; NM_004226.3.
DR   UniGene; Hs.88297; -.
DR   PDB; 3LM0; X-ray; 2.35 A; A=25-329.
DR   PDB; 3LM5; X-ray; 2.29 A; A=25-329.
DR   PDBsum; 3LM0; -.
DR   PDBsum; 3LM5; -.
DR   ProteinModelPortal; O94768; -.
DR   SMR; O94768; 25-301.
DR   IntAct; O94768; 3.
DR   STRING; O94768; -.
DR   PhosphoSite; O94768; -.
DR   PRIDE; O94768; -.
DR   Ensembl; ENST00000263955; ENSP00000263955; ENSG00000081320.
DR   Ensembl; ENST00000409228; ENSP00000386853; ENSG00000081320.
DR   GeneID; 9262; -.
DR   KEGG; hsa:9262; -.
DR   UCSC; uc002utk.1; human.
DR   CTD; 9262; -.
DR   GeneCards; GC02M188851; -.
DR   H-InvDB; HIX0002694; -.
DR   HGNC; HGNC:11396; STK17B.
DR   HPA; HPA034858; -.
DR   MIM; 604727; gene.
DR   neXtProt; NX_O94768; -.
DR   PharmGKB; PA36204; -.
DR   eggNOG; prNOG13206; -.
DR   InParanoid; O94768; -.
DR   OMA; HEIAILE; -.
DR   OrthoDB; EOG4GTKD7; -.
DR   PhylomeDB; O94768; -.
DR   BRENDA; 2.7.11.1; 2681.
DR   NextBio; 34721; -.
DR   ArrayExpress; O94768; -.
DR   Bgee; O94768; -.
DR   CleanEx; HS_STK17B; -.
DR   Genevestigator; O94768; -.
DR   GermOnline; ENSG00000081320; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
DR   GO; GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS2.PE4700; -.
KW   ENSG000000813201755old_1320000031; ENSP000003868537901old_1320000031;
KW   C9JZJ1_HUMAN; Q53QE7_HUMAN; Q6FG83_HUMAN; Q6FG98_HUMAN; AB011421;
KW   AK312865; BC016040; CH471063; CR542210; CR542225;
KW   3D-structure; Apoptosis; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   372 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA
     AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS
     LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF
     GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN
     QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN
     LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL
     PNPHELVSDL LC
//

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