(data stored in ACNUC13749 zone)

HOGENOM: HS2_PE489

ID   HS2_PE489                            STANDARD;      PRT;   627 AA.
AC   HS2_PE489; O60941; O43782; O60881; O75538; Q9UE14; Q9UE15; Q9UE16;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dystrobrevin beta; Short=DTN-B;AltName:
DE   Full=Beta-dystrobrevin; (HS2.PE489).
GN   Name=DTNB;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS2.PE489.
CC       Homo sapiens chromosome 2 GRCh37  sequence 1..243189373 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DTNB_HUMAN
CC   -!- SUBUNIT: Interacts with dystrophin short form DP71 and syntrophins
CC       SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC         Comment=Additional isoforms seem to exist;
CC       Name=1; Synonyms=DTN-B1;
CC         IsoId=O60941-1; Sequence=Displayed;
CC       Name=2; Synonyms=Dystrophin-associated protein A0;
CC         IsoId=O60941-2; Sequence=VSP_004223, VSP_004226;
CC       Name=3; Synonyms=DTN-B2;
CC         IsoId=O60941-3; Sequence=VSP_004224, VSP_004225;
CC         Note=May be produced at very low levels due to a premature stop
CC         codon in the mRNA, leading to nonsense-mediated mRNA decay;
CC       Name=4;
CC         IsoId=O60941-4; Sequence=VSP_004226;
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain, kidney and
CC       pancreas.
CC   -!- DOMAIN: The coiled coil domain may mediate the interaction with
CC       dystrophin.
CC   -!- SIMILARITY: Belongs to the dystrophin family. Dystrobrevin
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 ZZ-type zinc finger.
CC   -!- GENE_FAMILY: HOG000230684 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000138101;ENST00000406818;ENSP00000384084.
DR   EMBL; AC010150; - ;
DR   EMBL; AC012074; - ;
DR   EMBL; AC019144; - ;
DR   EMBL; AC104699; - ;
DR   EMBL; AF022728; - ;
DR   EMBL; AF070567; - ;
DR   EMBL; AK294357; - ;
DR   EMBL; Y12712; - ;
DR   EMBL; Y15718; - ;
DR   EMBL; Y15719; - ;
DR   EMBL; Y15720; - ;
DR   EMBL; Y15721; - ;
DR   EMBL; Y15722; - ;
DR   UniProtKB/Swiss-Prot; O60941; O43782; O60881; O75538; Q9UE14; Q9UE15; Q9UE16; -.
DR   EMBL; AF022728; AAC05082.1; -; mRNA.
DR   EMBL; Y15722; CAA75737.1; -; mRNA.
DR   EMBL; Y12712; CAA73249.1; -; mRNA.
DR   EMBL; Y15718; CAA75733.1; -; mRNA.
DR   EMBL; Y15719; CAA75734.1; -; mRNA.
DR   EMBL; Y15720; CAA75735.1; -; mRNA.
DR   EMBL; Y15721; CAA75736.1; -; mRNA.
DR   EMBL; AF070567; AAC28643.1; -; mRNA.
DR   IPI; IPI00219529; -.
DR   IPI; IPI00219530; -.
DR   IPI; IPI00299362; -.
DR   IPI; IPI00373897; -.
DR   RefSeq; NP_068707.1; NM_021907.3.
DR   RefSeq; NP_149159.2; NM_033147.2.
DR   RefSeq; NP_149160.1; NM_033148.2.
DR   UniGene; Hs.307720; -.
DR   ProteinModelPortal; O60941; -.
DR   SMR; O60941; 3-292.
DR   IntAct; O60941; 6.
DR   MINT; MINT-109678; -.
DR   STRING; O60941; -.
DR   PhosphoSite; O60941; -.
DR   PRIDE; O60941; -.
DR   Ensembl; ENST00000406818; ENSP00000384084; ENSG00000138101.
DR   GeneID; 1838; -.
DR   KEGG; hsa:1838; -.
DR   UCSC; uc002rgh.1; human.
DR   UCSC; uc002rgj.1; human.
DR   UCSC; uc002rgk.1; human.
DR   UCSC; uc002rgr.1; human.
DR   CTD; 1838; -.
DR   GeneCards; GC02M025337; -.
DR   H-InvDB; HIX0001885; -.
DR   HGNC; HGNC:3058; DTNB.
DR   MIM; 602415; gene.
DR   neXtProt; NX_O60941; -.
DR   PharmGKB; PA27511; -.
DR   eggNOG; prNOG14507; -.
DR   InParanoid; O60941; -.
DR   OMA; MELEPRV; -.
DR   OrthoDB; EOG40GCQ7; -.
DR   NextBio; 7517; -.
DR   ArrayExpress; O60941; -.
DR   Bgee; O60941; -.
DR   CleanEx; HS_DTNB; -.
DR   Genevestigator; O60941; -.
DR   GermOnline; ENSG00000138101; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR017432; Distrobrevin.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR015153; EF-hand_dom_typ1.
DR   InterPro; IPR015154; EF-hand_dom_typ2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF09068; efhand_1; 1.
DR   Pfam; PF09069; efhand_2; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   PIRSF; PIRSF038204; Distrobrevin; 1.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
DR   HOGENOMDNA; HS2.PE489; -.
KW   ENSG000001381011755old_1320000031; ENSP000003840847901old_1320000031;
KW   B7Z258_HUMAN; Q53QV1_HUMAN; Q53SF9_HUMAN; Q53T51_HUMAN; Q53TC8_HUMAN;
KW   AC012074; AC019144; AC104699; AF022728; AF070567; AK294357; Y12712;
KW   Y15719; Y15720; Y15721; Y15722;
KW   Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
SQ   SEQUENCE   627 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE
     AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD
     SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA
     VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP
     VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
     HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR
     LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT
     RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA
     ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG
     GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
     SLVKELHSAE EGAEEEEEKM QNGKDRG
//

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