(data stored in ACNUC24361 zone)

HOGENOM: HS3_PE1354

ID   HS3_PE1354                           STANDARD;      PRT;   1031 AA.
AC   HS3_PE1354; P59923; Q3MJD1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Zinc finger protein 445;AltName: Full=Zinc finger protein
DE   168;AltName: Full=Zinc finger protein with KRAB and SCAN domains 15;
DE   (HS3.PE1354).
GN   Name=ZNF445; Synonyms=ZKSCAN15, ZNF168;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS3.PE1354.
CC       Homo sapiens chromosome 3 GRCh37  sequence 1..197962430 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ZN445_HUMAN
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 14 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000185219;ENST00000296111;ENSP00000296111.
DR   EMBL; AY262260; - ;
DR   EMBL; AY295873; - ;
DR   EMBL; BC101486; - ;
DR   EMBL; BC143439; - ;
DR   UniProtKB/Swiss-Prot; P59923; Q3MJD1; -.
DR   EMBL; AY262260; AAP36990.1; -; mRNA.
DR   EMBL; AY295873; AAP50258.1; -; mRNA.
DR   EMBL; BC101486; AAI01487.1; -; mRNA.
DR   IPI; IPI00377116; -.
DR   RefSeq; NP_852466.1; NM_181489.5.
DR   UniGene; Hs.250481; -.
DR   ProteinModelPortal; P59923; -.
DR   SMR; P59923; 49-138, 228-282, 356-616, 652-1028.
DR   IntAct; P59923; 1.
DR   STRING; P59923; -.
DR   PRIDE; P59923; -.
DR   Ensembl; ENST00000296111; ENSP00000296111; ENSG00000185219.
DR   Ensembl; ENST00000396077; ENSP00000379387; ENSG00000185219.
DR   Ensembl; ENST00000425708; ENSP00000413073; ENSG00000185219.
DR   GeneID; 353274; -.
DR   KEGG; hsa:353274; -.
DR   UCSC; uc003cnf.2; human.
DR   CTD; 353274; -.
DR   GeneCards; GC03M044481; -.
DR   HGNC; HGNC:21018; ZNF445.
DR   HPA; HPA006678; -.
DR   neXtProt; NX_P59923; -.
DR   PharmGKB; PA134904986; -.
DR   eggNOG; prNOG05702; -.
DR   GeneTree; ENSGT00570000079264; -.
DR   InParanoid; P59923; -.
DR   OMA; FWCQECG; -.
DR   OrthoDB; EOG4V6ZFT; -.
DR   PhylomeDB; P59923; -.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 99754; -.
DR   ArrayExpress; P59923; -.
DR   Bgee; P59923; -.
DR   CleanEx; HS_ZNF445; -.
DR   Genevestigator; P59923; -.
DR   GermOnline; ENSG00000185219; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 14.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 13.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
DR   HOGENOMDNA; HS3.PE1354; -.
KW   ENSG000001852191755old_1320000031; ENSP000002961117901old_1320000031;
KW   B7ZKX2_HUMAN; AY262260; AY295873; BC101486; BC143439;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
SQ   SEQUENCE   1031 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPPGRWHAAY PAQAQSSRER GRLQTVKKEE EDESYTPVQA ARPQTLNRPG QELFRQLFRQ
     LRYHESSGPL ETLSRLRELC RWWLRPDVLS KAQILELLVL EQFLSILPGE LRVWVQLHNP
     ESGEEAVALL EELQRDLDGT SWRDPGPAQS PDVHWMGTGA LRSAQIWSLA SPLRSSSALG
     DHLEPPYEIE ARDFLAGQSD TPAAQMPALF PREGCPGDQV TPTRSLTAQL QETMTFKDVE
     VTFSQDEWGW LDSAQRNLYR DVMLENYRNM ASLVGPFTKP ALISWLEARE PWGLNMQAAQ
     PKGNPVAAPT GDDLQSKTNK FILNQEPLEE AETLAVSSGC PATSVSEGIG LRESFQQKSR
     QKDQCENPIQ VRVKKEETNF SHRTGKDSEV SGSNSLDLKH VTYLRVSGRK ESLKHGCGKH
     FRMSSHHYDY KKYGKGLRHM IGGFSLHQRI HSGLKGNKKD VCGKDFSLSS HHQRGQSLHT
     VGVSFKCSDC GRTFSHSSHL AYHQRLHTQE KAFKCRVCGK AFRWSSNCAR HEKIHTGVKP
     YKCDLCEKAF RRLSAYRLHR ETHAKKKFLE LNQYRAALTY SSGFDHHLGD QSGEKLFDCS
     QCRKSFHCKS YVLEHQRIHT QEKPYKCTKC RKTFRWRSNF TRHMRLHEEE KFYKQDECRE
     GFRQSPDCSQ PQGAPAVEKT FLCQQCGKTF TRKKTLVDHQ RIHTGEKPYQ CSDCGKDFAY
     RSAFIVHKKK HAMKRKPEGG PSFSQDTVFQ VPQSSHSKEE PYKCSQCGKA FRNHSFLLIH
     QRVHTGEKPY KCRECGKAFR WSSNLYRHQR IHSLQKQYDC HESEKTPNVE PKILTGEKRF
     WCQECGKTFT RKRTLLDHKG IHSGEKRYKC NLCGKSYDRN YRLVNHQRIH STERPFKCQW
     CGKEFIGRHT LSSHQRKHTR AAQAERSPPA RSSSQDTKLR LQKLKPSEEM PLEDCKEACS
     QSSRLTGLQD ISIGKKCHKC SICGKTFNKS SQLISHKRFH TRERPFKCSK CGKTFRWSSN
     LARHMKNHIR D
//

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