(data stored in ACNUC11314 zone)

HOGENOM: HS3_PE2559

ID   HS3_PE2559                           STANDARD;      PRT;   144 AA.
AC   HS3_PE2559; O95990; Q96NH4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein FAM107A;AltName: Full=Down-regulated in renal cell
DE   carcinoma 1;AltName: Full=Protein TU3A; (HS3.PE2559).
GN   Name=FAM107A; Synonyms=DRR1, TU3A;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS3.PE2559.
CC       Homo sapiens chromosome 3 GRCh37  sequence 1..197962430 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:F107A_HUMAN
CC   -!- FUNCTION: When transfected into cell lines in which it is not
CC       expressed, suppresses cell growth. May play a role in tumor
CC       development.
CC   -!- INTERACTION:
CC       P81605:DCD; NbExp=1; IntAct=EBI-743396, EBI-395625;
CC       P63151:PPP2R2A; NbExp=1; IntAct=EBI-743396, EBI-1048931;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95990-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95990-2; Sequence=VSP_009232;
CC         Note=May be due to an intron retention. No experimental
CC         confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed in normal tissues. Expression
CC       is reduced or absent in a number of cancer cell lines.
CC   -!- SIMILARITY: Belongs to the FAM107 family.
CC   -!- GENE_FAMILY: HOG000048230 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000168309;ENST00000360997;ENSP00000354270.
DR   EMBL; AB023810; - ;
DR   EMBL; AB023811; - ;
DR   EMBL; AC116036; - ;
DR   EMBL; AC119424; - ;
DR   EMBL; AF089853; - ;
DR   EMBL; AF089854; - ;
DR   EMBL; AK055443; - ;
DR   EMBL; AK128791; - ;
DR   EMBL; AL050264; - ;
DR   EMBL; BC010561; - ;
DR   EMBL; CH471055; - ;
DR   EMBL; CR457133; - ;
DR   EMBL; EU569833; - ;
DR   UniProtKB/Swiss-Prot; O95990; Q96NH4; -.
DR   EMBL; AF089854; AAD16094.1; -; mRNA.
DR   EMBL; AF089853; AAD16093.1; -; mRNA.
DR   EMBL; AB023810; BAA83072.1; -; Genomic_DNA.
DR   EMBL; AB023811; BAA82845.1; -; mRNA.
DR   EMBL; AL050264; CAB43366.1; -; mRNA.
DR   EMBL; AK055443; BAB70924.1; -; mRNA.
DR   EMBL; BC010561; AAH10561.1; -; mRNA.
DR   IPI; IPI00043668; -.
DR   IPI; IPI00939783; -.
DR   PIR; T08666; T08666.
DR   RefSeq; NP_001070246.1; NM_001076778.1.
DR   RefSeq; NP_009108.1; NM_007177.2.
DR   UniGene; Hs.506357; -.
DR   ProteinModelPortal; O95990; -.
DR   IntAct; O95990; 17.
DR   MINT; MINT-1392905; -.
DR   STRING; O95990; -.
DR   PRIDE; O95990; -.
DR   Ensembl; ENST00000360997; ENSP00000354270; ENSG00000168309.
DR   Ensembl; ENST00000394481; ENSP00000377991; ENSG00000168309.
DR   Ensembl; ENST00000421611; ENSP00000398219; ENSG00000168309.
DR   Ensembl; ENST00000447756; ENSP00000400858; ENSG00000168309.
DR   Ensembl; ENST00000474531; ENSP00000419124; ENSG00000168309.
DR   GeneID; 11170; -.
DR   KEGG; hsa:11170; -.
DR   UCSC; uc003dkm.1; human.
DR   UCSC; uc003dkp.1; human.
DR   CTD; 11170; -.
DR   GeneCards; GC03M058526; -.
DR   H-InvDB; HIX0003406; -.
DR   HGNC; HGNC:30827; FAM107A.
DR   MIM; 608295; gene.
DR   neXtProt; NX_O95990; -.
DR   PharmGKB; PA143485464; -.
DR   eggNOG; prNOG19946; -.
DR   InParanoid; O95990; -.
DR   OrthoDB; EOG4X3H30; -.
DR   PhylomeDB; O95990; -.
DR   NextBio; 42503; -.
DR   ArrayExpress; O95990; -.
DR   Bgee; O95990; -.
DR   CleanEx; HS_FAM107A; -.
DR   Genevestigator; O95990; -.
DR   GermOnline; ENSG00000168309; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0001558; P:regulation of cell growth; IDA:UniProtKB.
DR   InterPro; IPR009533; DUF1151.
DR   PANTHER; PTHR16768; DUF1151; 1.
DR   Pfam; PF06625; DUF1151; 1.
DR   HOGENOMDNA; HS3.PE2559; -.
KW   ENSG000001683091755old_1320000031; ENSP000003542707901old_1320000031;
KW   B3KY74_HUMAN; C9J003_HUMAN; C9JAU5_HUMAN; Q6IAM1_HUMAN; AB023810;
KW   AC116036; AC119424; AF089853; AF089854; AK055443; AK128791; AL050264;
KW   CH471055; CR457133; EU569833;
KW   Alternative splicing; Coiled coil; Complete proteome;
KW   Growth regulation; Nucleus; Polymorphism; Reference proteome.
SQ   SEQUENCE   144 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG
     VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQL EKPPEKEEDH
     APEFIKVREN LRRIATLTSE EREL
//

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