(data stored in ACNUC5448 zone)

HOGENOM: HS3_PE3706

ID   HS3_PE3706                           STANDARD;      PRT;   1654 AA.
AC   HS3_PE3706; C9IZQ6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=HCG2022551, isoform CRA_j;SubName: Full=Uncharacterized
DE   protein; (HS3.PE3706).
GN   Name=KALRN; ORFNames=hCG_2022551;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS3.PE3706.
CC       Homo sapiens chromosome 3 GRCh37  sequence 1..197962430 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:C9IZQ6_HUMAN
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 DH (DBL-homology) domain.
CC   -!- GENE_FAMILY: HOG000044462 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000160145;ENST00000460856;ENSP00000418611.
DR   EMBL; AC022336; - ;
DR   EMBL; AC069233; - ;
DR   EMBL; AC080008; - ;
DR   EMBL; AC112129; - ;
DR   EMBL; AC117401; - ;
DR   EMBL; CH471052; - ;
DR   UniProtKB/Swiss-Prot; C9IZQ6; -.
DR   EMBL; AC022336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC080008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW79423.1; -; Genomic_DNA.
DR   IPI; IPI00946196; -.
DR   UniGene; Hs.8004; -.
DR   ProteinModelPortal; C9IZQ6; -.
DR   SMR; C9IZQ6; 1270-1573.
DR   STRING; C9IZQ6; -.
DR   Ensembl; ENST00000460856; ENSP00000418611; ENSG00000160145.
DR   HGNC; HGNC:4814; KALRN.
DR   GeneTree; ENSGT00560000076675; -.
DR   Bgee; C9IZQ6; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   InterPro; IPR001251; CRAL-bd_TRIO_C.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:3.40.525.10; CRAL_bd_TRIO_C; 1.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Gene3D; G3DSA:1.20.900.10; RhoGEF; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00150; SPEC; 7.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   SUPFAM; SSF48065; DH-domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; HS3.PE3706; -.
KW   ENSG000001601451755old_1320000031; ENSP000004186117901old_1320000031;
KW   AC022336; AC069233; AC080008; AC112129; AC117401; CH471052;
KW   Complete proteome; Reference proteome; Repeat.
SQ   SEQUENCE   1654 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR DKRGGPILTF
     PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM RGSKWDLIKP LLKTLQEAFP
     AEIHVALIIK PDNFWQKQKT NFGSSKFIFE TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH
     EEWIELRLSL EEFFNSAVHL LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA
     PVEELDREGQ RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
     VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL QTQHNHFAMN
     SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW KSFAAALDER STILAMSAVF
     HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL ELAIHHHQTL YEQVTQAYTE VSQDGKALLD
     VLQRPLSPGN SESLTATANY SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV
     FQQDVQQVLD WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
     AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT KELWTWMEDL
     QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE GEDLIQQLRS APPSLGEPSE
     ARDSAVSNNK TPHSSSISHI ESVLQQLDDA QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE
     VTAELDAWNE DLLRQMNDFN TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT
     EVQASGIELI CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
     QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI EKTHQSALQV QQKAEVLLQA
     GHYDADAIRE CAEKVALHWQ QLMLKMEDRL KLVNASVAFY KTSEQVCSVL ESLEQEYRRD
     EDWCGGRDKL GPAAEIDHVI PLISKHLEQK EAFLKACTLA RRNAEVFLKY IHRNNVSMPS
     VASHTRGPEQ QVKAILSELL QRENRVLHFW TLKKRRLDQC QQYVVFERSA KQALDWIQET
     GEFYLSTHTS TGETTEETQE LLKEYGEFRV PAKQTKEKVK LLIQLADSFV EKGHIHATEI
     RKWVTTVDKH YRDFSLRMGK YRYSLEKALG VNTEDNKDLE LDIIPASLSD REVKLRDANH
     EVNEEKRKSA RKKEFIMAEL LQTEKAYVRD LHECLETYLW EMTSGVEEIP PGILNKEHII
     FGNIQEIYDF HNNIFLKELE KYEQLPEDVG HCFVTWADKF QMYVTYCKNK PDSNQLILEH
     AGTFFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL TCCEEGKGEL KDGLEVMLSV
     PKKANDAMHV SMLEGFDENL DVQGELILQD AFQVWDPKSL IRKGRERHLF LFEISLVFSK
     EIKDSSGHTK YVYKNKLLTS ELGVTEHVEG DPCKFALWSG RTPSSDNKTV LKASNIETKQ
     EWIKNIREVI QERIIHLKGA LKEPLQLPKT PAKQRNNSKR DGVEDIDSQG DGSSQPDTIS
     IASRTSQNTV DSDKDGNLVP RWHLGPGDPF STYV
//

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