(data stored in ACNUC5448 zone)

HOGENOM: HS3_PE3711

ID   HS3_PE3711                           STANDARD;      PRT;   1289 AA.
AC   HS3_PE3711; C9JQ37;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=HCG2039851, isoform CRA_a;SubName: Full=Uncharacterized
DE   protein; (HS3.PE3711).
GN   Name=KALRN; ORFNames=hCG_2039851;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS3.PE3711.
CC       Homo sapiens chromosome 3 GRCh37  sequence 1..197962430 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:C9JQ37_HUMAN
CC   -!- GENE_FAMILY: HOG000294214 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000160145;ENST00000291478;ENSP00000291478.
DR   EMBL; AC022336; - ;
DR   EMBL; AC069233; - ;
DR   EMBL; AC080008; - ;
DR   EMBL; AC112129; - ;
DR   EMBL; AC117401; - ;
DR   EMBL; CH471052; - ;
DR   UniProtKB/Swiss-Prot; C9JQ37; -.
DR   EMBL; AC022336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC080008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW79410.1; -; Genomic_DNA.
DR   IPI; IPI00953447; -.
DR   RefSeq; NP_008995.2; NM_007064.3.
DR   UniGene; Hs.8004; -.
DR   ProteinModelPortal; C9JQ37; -.
DR   SMR; C9JQ37; 222-551, 628-693, 770-967, 980-1271.
DR   STRING; C9JQ37; -.
DR   Ensembl; ENST00000291478; ENSP00000291478; ENSG00000160145.
DR   GeneID; 8997; -.
DR   KEGG; hsa:8997; -.
DR   CTD; 8997; -.
DR   HGNC; HGNC:4814; KALRN.
DR   GeneTree; ENSGT00560000076675; -.
DR   Bgee; C9JQ37; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR003961; FN_III.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   InterPro; IPR001452; SH3_domain.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Gene3D; G3DSA:1.20.900.10; RhoGEF; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DH-domain; 1.
DR   SUPFAM; SSF49265; FN_III-like; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   SUPFAM; SSF50044; SH3; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HS3.PE3711; -.
KW   ENSG000001601451755old_1320000031; ENSP000002914787901old_1320000031;
KW   AC022336; AC069233; AC080008; AC112129; AC117401; CH471052;
KW   ATP-binding; Complete proteome; Nucleotide-binding;
KW   Reference proteome.
SQ   SEQUENCE   1289 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKGGDRAYTR GPSLGWLFAK CCCCFPCRDA YSHSSSENGG KSESVANLQA QPSLNSIHSS
     PGPKRSTNTL KKWLTSPVRR LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS
     ADEKSKKGWG EDEPDEESHT PLPPPMKIFD NDPTQDEMSS SLLAARQAST EVPTAADLVN
     AIEKLVKNKL SLEGSSYRGS LKDPAGCLNE GMAPPTPPKN PEEEQKAKAL RGRMFVLNEL
     VQTEKDYVKD LGIVVEGFMK RIEEKGVPED MRGKDKIVFG NIHQIYDWHK DFFLAELEKC
     IQEQDRLAQL FIKHERKLHI YVWYCQNKPR SEYIVAEYDA YFEEVKQEIN QRLTLSDFLI
     KPIQRITKYQ LLLKDFLRYS EKAGLECSDI EKAVELMCLV PKRCNDMMNL GRLQGFEGTL
     TAQGKLLQQD TFYVIELDAG MQSRTKERRV FLFEQIVIFS ELLRKGSLTP GYMFKRSIKM
     NYLVLEENVD NDPCKFALMN RETSERVVLQ AANADIQQAW VQDINQVLET QRDFLNALQS
     PIEYQRKERS TAVMRSQPAR LPQASPRPYS SVPAGSEKPP KGSSYNPPLP PLKISTSNGS
     PGFEYHQPGD KFEASKQNDL GGCNGTSSMA VIKDYYALKE NEICVSQGEV VQVLAVNQQN
     MCLVYQPASD HSPAAEGWVP GSILAPLTKA TAAESSDGSI KKSCSWHTLR MRKRAEVENT
     GKNEATGPRK PKDILGNKVS VKETNSSEES ECDDLDPNTS MEILNPNFIQ EVAPEFLVPL
     VDVTCLLGDT VILQCKVCGR PKPTITWKGP DQNILDTDNS SATYTVSSCD SGEITLKICN
     LMPQDSGIYT CIATNDHGTT STSATVKVQG VPAAPNRPIA QERSCTSVIL RWLPPSSTGN
     CTISGYTVEY REEGSQIWQQ SVASTLDTYL VIEDLSPGCP YQFRVSASNP WGISLPSEPS
     EFVRLPEYDA AADGATISWK ENFDSAYTEL NEIGRGRFSI VKKCIHKATR KDVAVKFVSK
     KMKKKEQAAH EAALLQHLQH PQYITLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME
     EKVAFYIRDI MEALQYLHNC RVAHLDIKPE NLLIDLRIPV PRVKLIDLED AVQISGHFHI
     HHLLGNPEFA APEVIQGIPV SLGTDIWSIG VLTYVMLSGV SPFLDESKEE TCINVCRVDF
     SFPHEYFCGV SNAARDFINV ILQEDFRRRP TAATCLQHPW LQPHNGSYSK IPLDTSRLAC
     FIERRKHQND VRPIPNVKSY IVNRVNQGT
//

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