(data stored in ACNUC27125 zone)

HOGENOM: HS4_PE2252

ID   HS4_PE2252                           STANDARD;      PRT;   521 AA.
AC   HS4_PE2252; Q08209; A8K3B7; B5BUA2; Q8TAW9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit
DE   alpha isoform; EC=3.1.3 16;AltName: Full=CAM-PRP catalytic
DE   subunit;AltName: Full=Calmodulin-dependent calcineurin A subunit alpha
DE   isoform; (HS4.PE2252).
GN   Name=PPP3CA; Synonyms=CALNA, CNA;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS4.PE2252.
CC       Homo sapiens chromosome 4 GRCh37  sequence 1..191044276 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PP2BA_HUMAN
CC   -!- FUNCTION: Calcium-dependent, calmodulin-stimulated protein
CC       phosphatase. This subunit may have a role in the calmodulin
CC       activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit.
CC   -!- SUBUNIT: Composed of two components (A and B), the A component is
CC       the catalytic subunit and the B component confers calcium
CC       sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3.
CC       Interacts with DNM1L; the interaction dephosphorylates DNM1L and
CC       regulates its translocation to mitochondria.
CC   -!- INTERACTION:
CC       P62993:GRB2; NbExp=2; IntAct=EBI-352922, EBI-401755;
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Colocalizes
CC       with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle
CC       (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q08209-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q08209-2; Sequence=VSP_018562;
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-2B
CC       subfamily.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Calcineurin entry;
CC       URL="http://en.wikipedia.org/wiki/Calcineurin";
CC   -!- GENE_FAMILY: HOG000172699 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000138814;ENST00000394854;ENSP00000378323.
DR   EMBL; AB451338; - ;
DR   EMBL; AB451487; - ;
DR   EMBL; AC092671; - ;
DR   EMBL; AK290532; - ;
DR   EMBL; AL353950; - ;
DR   EMBL; AP001816; - ;
DR   EMBL; AP001870; - ;
DR   EMBL; AP001939; - ;
DR   EMBL; AY904364; - ;
DR   EMBL; BC025714; - ;
DR   EMBL; CH471057; - ;
DR   EMBL; J05480; - ;
DR   EMBL; L14778; - ;
DR   EMBL; S40012; - ;
DR   UniProtKB/Swiss-Prot; Q08209; A8K3B7; B5BUA2; Q8TAW9; -.
DR   EMBL; L14778; AAA02631.1; -; mRNA.
DR   EMBL; AK290532; BAF83221.1; -; mRNA.
DR   EMBL; AL353950; CAB89253.1; -; mRNA.
DR   EMBL; AB451338; BAG70152.1; -; mRNA.
DR   EMBL; AB451487; BAG70301.1; -; mRNA.
DR   EMBL; CH471057; EAX06125.1; -; Genomic_DNA.
DR   EMBL; CH471057; EAX06124.1; -; Genomic_DNA.
DR   EMBL; BC025714; AAH25714.1; -; mRNA.
DR   IPI; IPI00179415; -.
DR   IPI; IPI00747748; -.
DR   PIR; S35067; S35067.
DR   RefSeq; NP_000935.1; NM_000944.4.
DR   RefSeq; NP_001124163.1; NM_001130691.1.
DR   UniGene; Hs.435512; -.
DR   PDB; 1AUI; X-ray; 2.10 A; A=1-521.
DR   PDB; 1M63; X-ray; 2.80 A; A/E=1-372.
DR   PDB; 1MF8; X-ray; 3.10 A; A=20-392.
DR   PDB; 2JOG; NMR; -; A=21-347.
DR   PDB; 2JZI; NMR; -; B=391-414.
DR   PDB; 2P6B; X-ray; 2.30 A; A/C=1-380.
DR   PDB; 2R28; X-ray; 1.86 A; C/D=389-413.
DR   PDB; 2W73; X-ray; 1.45 A; K/L/M/O=395-411.
DR   PDB; 3LL8; X-ray; 2.00 A; A/C=14-370.
DR   PDBsum; 1AUI; -.
DR   PDBsum; 1M63; -.
DR   PDBsum; 1MF8; -.
DR   PDBsum; 2JOG; -.
DR   PDBsum; 2JZI; -.
DR   PDBsum; 2P6B; -.
DR   PDBsum; 2R28; -.
DR   PDBsum; 2W73; -.
DR   PDBsum; 3LL8; -.
DR   ProteinModelPortal; Q08209; -.
DR   SMR; Q08209; 14-370.
DR   DisProt; DP00092; -.
DR   DIP; DIP-29315N; -.
DR   DIP; DIP-6095N; -.
DR   IntAct; Q08209; 7.
DR   MINT; MINT-1037516; -.
DR   STRING; Q08209; -.
DR   PhosphoSite; Q08209; -.
DR   PRIDE; Q08209; -.
DR   Ensembl; ENST00000394854; ENSP00000378323; ENSG00000138814.
DR   GeneID; 5530; -.
DR   KEGG; hsa:5530; -.
DR   UCSC; uc003hvu.1; human.
DR   UCSC; uc003hvv.1; human.
DR   CTD; 5530; -.
DR   GeneCards; GC04M097682; -.
DR   H-InvDB; HIX0004409; -.
DR   HGNC; HGNC:9314; PPP3CA.
DR   HPA; CAB018581; -.
DR   HPA; HPA012778; -.
DR   MIM; 114105; gene.
DR   neXtProt; NX_Q08209; -.
DR   InParanoid; Q08209; -.
DR   OMA; SVWPAGP; -.
DR   OrthoDB; EOG4PVNZK; -.
DR   PhylomeDB; Q08209; -.
DR   Pathway_Interaction_DB; bcr_5pathway; BCR signaling pathway.
DR   Pathway_Interaction_DB; tcrcalciumpathway; Calcium signaling in the CD4+ TCR pathway.
DR   Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; il12_stat4pathway; IL12 signaling mediated by STAT4.
DR   Pathway_Interaction_DB; il12_2pathway; IL12-mediated signaling events.
DR   Pathway_Interaction_DB; nfat_3pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes.
DR   Reactome; REACT_15295; Opioid Signalling.
DR   NextBio; 21422; -.
DR   PMAP-CutDB; Q08209; -.
DR   ArrayExpress; Q08209; -.
DR   Bgee; Q08209; -.
DR   CleanEx; HS_PPP3CA; -.
DR   Genevestigator; Q08209; -.
DR   GermOnline; ENSG00000138814; Homo sapiens.
DR   GO; GO:0005955; C:calcineurin complex; NAS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; NAS:UniProtKB.
DR   GO; GO:0006470; P:protein dephosphorylation; NAS:UniProtKB.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR   HOGENOMDNA; HS4.PE2252; -.
KW   ENSG000001388141755old_1320000031; ENSP000003783237901old_1320000031;
KW   A1A441_HUMAN; D6RBS6_HUMAN; Q9UMB2_HUMAN; Q9UMM5_HUMAN; AB451338;
KW   AC092671; AK290532; AL353950; AP001816; AP001870; AP001939; AY904364;
KW   CH471057; J05480; L14778; S40012;
KW   3D-structure; Alternative splicing; Calmodulin-binding;
KW   Complete proteome; Hydrolase; Iron; Metal-binding; Nucleus;
KW   Phosphoprotein; Protein phosphatase; Reference proteome; Zinc.
SQ   SEQUENCE   521 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
     ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
     DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
     AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
     NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
     SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
     VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
     LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
     ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q
//

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