(data stored in ACNUC30567 zone)

HOGENOM: HS4_PE3502

ID   HS4_PE3502                           STANDARD;      PRT;   820 AA.
AC   HS4_PE3502; Q9UKF5; Q9UHP1; Q9UKF3; Q9UKF4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   29; Short=ADAM 29;AltName: Full=Cancer/testis antigen 73;
DE   Short=CT73;Flags: Precursor; (HS4.PE3502).
GN   Name=ADAM29;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS4.PE3502.
CC       Homo sapiens chromosome 4 GRCh37  sequence 1..191044276 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADA29_HUMAN
CC   -!- FUNCTION: May be involved in spermatogenesis and fertilization.
CC       Seems to be a non catalytic metalloprotease-like protein.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Alpha;
CC         IsoId=Q9UKF5-1; Sequence=Displayed;
CC       Name=Beta;
CC         IsoId=Q9UKF5-2; Sequence=VSP_005491;
CC       Name=Gamma;
CC         IsoId=Q9UKF5-3; Sequence=VSP_005492, VSP_005493;
CC   -!- TISSUE SPECIFICITY: Expressed specifically in testes.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000168594;ENST00000404450;ENSP00000384229.
DR   EMBL; AC093868; - ;
DR   EMBL; AC105914; - ;
DR   EMBL; AF134708; - ;
DR   EMBL; AF171929; - ;
DR   EMBL; AF171930; - ;
DR   EMBL; AF171931; - ;
DR   EMBL; AK292410; - ;
DR   EMBL; CH471056; - ;
DR   UniProtKB/Swiss-Prot; Q9UKF5; Q9UHP1; Q9UKF3; Q9UKF4; -.
DR   EMBL; AF171929; AAF03777.1; -; mRNA.
DR   EMBL; AF171930; AAF03778.1; -; mRNA.
DR   EMBL; AF171931; AAF03779.1; -; mRNA.
DR   EMBL; AF134708; AAF22163.1; -; mRNA.
DR   IPI; IPI00029112; -.
DR   IPI; IPI00029113; -.
DR   IPI; IPI00289829; -.
DR   RefSeq; NP_001124175.1; NM_001130703.1.
DR   RefSeq; NP_001124176.1; NM_001130704.1.
DR   RefSeq; NP_001124177.1; NM_001130705.1.
DR   RefSeq; NP_055084.3; NM_014269.4.
DR   UniGene; Hs.126838; -.
DR   ProteinModelPortal; Q9UKF5; -.
DR   SMR; Q9UKF5; 190-659.
DR   MINT; MINT-252736; -.
DR   STRING; Q9UKF5; -.
DR   MEROPS; M12.981; -.
DR   PhosphoSite; Q9UKF5; -.
DR   PRIDE; Q9UKF5; -.
DR   Ensembl; ENST00000359240; ENSP00000352177; ENSG00000168594.
DR   Ensembl; ENST00000404450; ENSP00000384229; ENSG00000168594.
DR   Ensembl; ENST00000445694; ENSP00000414544; ENSG00000168594.
DR   GeneID; 11086; -.
DR   KEGG; hsa:11086; -.
DR   UCSC; uc003iuc.1; human.
DR   CTD; 11086; -.
DR   GeneCards; GC04P171588; -.
DR   H-InvDB; HIX0031373; -.
DR   HGNC; HGNC:207; ADAM29.
DR   HPA; HPA014159; -.
DR   MIM; 604778; gene.
DR   neXtProt; NX_Q9UKF5; -.
DR   GeneTree; ENSGT00590000082741; -.
DR   InParanoid; Q9UKF5; -.
DR   OMA; GTSHKCP; -.
DR   OrthoDB; EOG4XWFX8; -.
DR   PhylomeDB; Q9UKF5; -.
DR   NextBio; 42152; -.
DR   ArrayExpress; Q9UKF5; -.
DR   Bgee; Q9UKF5; -.
DR   CleanEx; HS_ADAM29; -.
DR   Genevestigator; Q9UKF5; -.
DR   GermOnline; ENSG00000168594; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; FALSE_NEG.
DR   PROSITE; PS50026; EGF_3; FALSE_NEG.
DR   PROSITE; PS00142; ZINC_PROTEASE; FALSE_NEG.
DR   HOGENOMDNA; HS4.PE3502; -.
KW   ENSG000001685941755old_1320000031; ENSP000003842297901old_1320000031;
KW   D6RBU0_HUMAN; D6RHU0_HUMAN; Q4W5F3_HUMAN; AC093868; AC105914; AF134708;
KW   AF171930; AF171931; AK292410; CH471056;
KW   Alternative splicing; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   820 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG WLSYILPFGG
     QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC YYHGYVEGDP ESLVSLSTCF
     GGFQGILQIN DFAYEIKPLA FSTTFEHLVY KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI
     DNSTQKQSSY VGWWIHFRIV EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG
     VKVLLFGLEI WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI
     GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS QPRCIMHEGN
     PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC GNGVVEEGEE CDCGPLKHCA
     KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY
     VEDGIPCKER GYCYEKSCHD RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT
     YIKCNISDVQ CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD
     GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP PNCLIKGYGG
     SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK SKPIKKQQDV QTPSAKEEEK
     IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP
     VMPSQSHPQL TPSQSQPPVT PSQRQPQLMP SQSQPPVTPS
//

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