(data stored in ACNUC9543 zone)

HOGENOM: HS4_PE751

ID   HS4_PE751                            STANDARD;      PRT;   795 AA.
AC   HS4_PE751; O43143; Q9NQT7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA
DE   helicase DHX15; EC=3.6.4 13;AltName: Full=ATP-dependent RNA helicase
DE   #46;AltName: Full=DEAH box protein 15; (HS4.PE751).
GN   Name=DHX15; Synonyms=DBP1, DDX15;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS4.PE751.
CC       Homo sapiens chromosome 4 GRCh37  sequence 1..191044276 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX15_HUMAN
CC   -!- FUNCTION: Pre-mRNA processing factor involved in disassembly of
CC       spliceosomes after the release of mature mRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Interacts with SSB/La. Component of the U11/U12 snRNPs
CC       that are part of the U12-type spliceosome.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX15/PRP43 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000109606;ENST00000336812;ENSP00000336741.
DR   EMBL; AB001636; - ;
DR   EMBL; AF279891; - ;
DR   EMBL; AK303506; - ;
DR   EMBL; BC035974; - ;
DR   UniProtKB/Swiss-Prot; O43143; Q9NQT7; -.
DR   EMBL; AB001636; BAA23987.1; -; mRNA.
DR   EMBL; AF279891; AAF90182.1; -; mRNA.
DR   EMBL; BC035974; AAH35974.1; -; mRNA.
DR   IPI; IPI00396435; -.
DR   PIR; JC5785; JC5785.
DR   RefSeq; NP_001349.2; NM_001358.2.
DR   UniGene; Hs.696074; -.
DR   ProteinModelPortal; O43143; -.
DR   SMR; O43143; 115-787.
DR   DIP; DIP-38211N; -.
DR   IntAct; O43143; 14.
DR   MINT; MINT-5003827; -.
DR   STRING; O43143; -.
DR   PhosphoSite; O43143; -.
DR   SWISS-2DPAGE; O43143; -.
DR   PRIDE; O43143; -.
DR   Ensembl; ENST00000336812; ENSP00000336741; ENSG00000109606.
DR   GeneID; 1665; -.
DR   KEGG; hsa:1665; -.
DR   UCSC; uc003gqx.1; human.
DR   CTD; 1665; -.
DR   GeneCards; GC04M023871; -.
DR   HGNC; HGNC:2738; DHX15.
DR   MIM; 603403; gene.
DR   neXtProt; NX_O43143; -.
DR   PharmGKB; PA27204; -.
DR   eggNOG; prNOG11716; -.
DR   GeneTree; ENSGT00550000074627; -.
DR   InParanoid; O43143; -.
DR   OMA; VIYNEFV; -.
DR   OrthoDB; EOG4K6G3N; -.
DR   PhylomeDB; O43143; -.
DR   NextBio; 6852; -.
DR   ArrayExpress; O43143; -.
DR   Bgee; O43143; -.
DR   CleanEx; HS_DHX15; -.
DR   Genevestigator; O43143; -.
DR   GermOnline; ENSG00000109606; Homo sapiens.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; IDA:HGNC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; TAS:ProtInc.
DR   GO; GO:0006397; P:mRNA processing; TAS:ProtInc.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS4.PE751; -.
KW   ENSG000001096061755old_1320000031; ENSP000003367417901old_1320000031;
KW   B4E0S6_HUMAN; AB001636; AF279891; AK303506; BC035974;
KW   Acetylation; ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome.
SQ   SEQUENCE   795 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE
     LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN
     LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS
     LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM
     LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF
     QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE
     EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS
     TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK
     CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL
     ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF
     VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV
     RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ
     LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL
     DRIIAKLQSK EYSQY
//

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