(data stored in ACNUC18858 zone)

HOGENOM: HS5_PE1252

ID   HS5_PE1252                           STANDARD;      PRT;   453 AA.
AC   HS5_PE1252; Q9P109;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein
DE   beta-1,6-N-acetylglucosaminyltransferase 4; EC=2.4.1 102;AltName:
DE   Full=Core 2-branching enzyme 3;AltName: Full=Core2-GlcNAc-transferase 3;
DE   Short=C2GnT3; (HS5.PE1252).
GN   Name=GCNT4;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE1252.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GCNT4_HUMAN
CC   -!- FUNCTION: Glycosyltransferase that mediates core 2 O-glycan
CC       branching, an important step in mucin-type biosynthesis. Does not
CC       have core 4 O-glycan or I-branching enzyme activity.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-
CC       galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-
CC       galactosaminyl-R.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type
CC       II membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in thymus. Weakly
CC       expressed in pancreas, peripheral blood leukocytes, placenta,
CC       small intestine and stomach. Barely detectable in liver, spleen,
CC       lung and lymph node.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC   -!- WEB RESOURCE: Name=GGDB; Note=GlycoGene database;
CC       URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GCNT4";
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Core
CC       2 beta-1,6-N-acetylglucosaminyltransferase 3.;
CC       URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_542";
CC   -!- GENE_FAMILY: HOG000293251 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000176928;ENST00000322348;ENSP00000317027.
DR   EMBL; AF132035; - ;
DR   UniProtKB/Swiss-Prot; Q9P109; -.
DR   EMBL; AF132035; AAF63156.1; -; mRNA.
DR   IPI; IPI00009879; -.
DR   RefSeq; NP_057675.1; NM_016591.2.
DR   UniGene; Hs.272404; -.
DR   ProteinModelPortal; Q9P109; -.
DR   SMR; Q9P109; 65-433.
DR   STRING; Q9P109; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PRIDE; Q9P109; -.
DR   Ensembl; ENST00000322348; ENSP00000317027; ENSG00000176928.
DR   GeneID; 51301; -.
DR   KEGG; hsa:51301; -.
DR   UCSC; uc003kdn.1; human.
DR   CTD; 51301; -.
DR   GeneCards; GC05M069528; -.
DR   H-InvDB; HIX0031975; -.
DR   HGNC; HGNC:17973; GCNT4.
DR   HPA; HPA037431; -.
DR   neXtProt; NX_Q9P109; -.
DR   PharmGKB; PA143485475; -.
DR   eggNOG; prNOG16727; -.
DR   GeneTree; ENSGT00550000074330; -.
DR   InParanoid; Q9P109; -.
DR   OMA; RFTYHHE; -.
DR   OrthoDB; EOG44TP84; -.
DR   PhylomeDB; Q9P109; -.
DR   BRENDA; 2.4.1.102; 2681.
DR   NextBio; 54601; -.
DR   ArrayExpress; Q9P109; -.
DR   Bgee; Q9P109; -.
DR   CleanEx; HS_GCNT4; -.
DR   Genevestigator; Q9P109; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IEDR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; TAS:ProtInc.
DR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; TAS:ProtInc.
DR   GO; GO:0006493; P:protein O-linked glycosylation; TAS:ProtInc.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
DR   HOGENOMDNA; HS5.PE1252; -.
KW   ENSG000001769281755old_1320000031; ENSP000003170277901old_1320000031;
KW   AF132035;
KW   Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase;
KW   Golgi apparatus; Membrane; Polymorphism; Reference proteome;
KW   Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   453 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKIFKCYFKH TLQQKVFILF LTLWLLSLLK LLNVRRLFPQ KDIYLVEYSL STSPFVRNRY
     THVKDEVRYE VNCSGIYEQE PLEIGKSLEI RRRDIIDLED DDVVAMTSDC DIYQTLRGYA
     QKLVSKEEKS FPIAYSLVVH KDAIMVERLI HAIYNQHNIY CIHYDRKAPD TFKVAMNNLA
     KCFSNIFIAS KLEAVEYAHI SRLQADLNCL SDLLKSSIQW KYVINLCGQD FPLKSNFELV
     SELKKLNGAN MLETVKPPNS KLERFTYHHE LRRVPYEYVK LPIRTNISKE APPHNIQIFV
     GSAYFVLSQA FVKYIFNNSI VQDFFAWSKD TYSPDEHFWA TLIRVPGIPG EISRSAQDVS
     DLQSKTRLVK WNYYEGFFYP SCTGSHLRSV CIYGAAELRW LIKDGHWFAN KFDSKVDPIL
     IKCLAEKLEE QQRDWITLPS EKLFMDRNLT TTS
//

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