(data stored in ACNUC5340 zone)

HOGENOM: HS5_PE1662

ID   HS5_PE1662                           STANDARD;      PRT;   106 AA.
AC   HS5_PE1662; P35754; B2R4L2; Q3KQS1; Q6ICT1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Glutaredoxin-1;AltName: Full=Thioltransferase-1;
DE   Short=TTase-1; (HS5.PE1662).
GN   Name=GLRX; Synonyms=GRX;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE1662.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GLRX1_HUMAN
CC   -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in
CC       the presence of NADPH and glutathione reductase. Reduces low
CC       molecular weight disulfides and proteins.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family.
CC   -!- SIMILARITY: Contains 1 glutaredoxin domain.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/glrx/";
CC   -!- GENE_FAMILY: HOG000095204 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000173221;ENST00000379979;ENSP00000369314.
DR   EMBL; AF069668; - ;
DR   EMBL; AF115104; - ;
DR   EMBL; AF115105; - ;
DR   EMBL; AF162769; - ;
DR   EMBL; AK311868; - ;
DR   EMBL; BC005304; - ;
DR   EMBL; BC010965; - ;
DR   EMBL; BC106075; - ;
DR   EMBL; BT006689; - ;
DR   EMBL; CH471062; - ;
DR   EMBL; CH471084; - ;
DR   EMBL; CR450312; - ;
DR   EMBL; CR542165; - ;
DR   EMBL; D21238; - ;
DR   EMBL; DQ026062; - ;
DR   EMBL; X76648; - ;
DR   UniProtKB/Swiss-Prot; P35754; B2R4L2; Q3KQS1; Q6ICT1; -.
DR   EMBL; D21238; BAA04769.1; -; mRNA.
DR   EMBL; X76648; CAA54094.1; -; mRNA.
DR   EMBL; AF069668; AAC35798.1; -; mRNA.
DR   EMBL; AF115105; AAC98318.1; -; Genomic_DNA.
DR   EMBL; AF115104; AAC98318.1; JOINED; Genomic_DNA.
DR   EMBL; AF162769; AAD43353.1; -; mRNA.
DR   EMBL; BT006689; AAP35335.1; -; mRNA.
DR   EMBL; CR450312; CAG29308.1; -; mRNA.
DR   EMBL; CR542165; CAG46962.1; -; mRNA.
DR   EMBL; AK311868; BAG34809.1; -; mRNA.
DR   EMBL; DQ026062; AAY29058.1; -; Genomic_DNA.
DR   EMBL; CH471084; EAW96056.1; -; Genomic_DNA.
DR   EMBL; BC005304; AAH05304.1; -; mRNA.
DR   EMBL; BC010965; AAH10965.1; -; mRNA.
DR   EMBL; BC106075; AAI06076.1; -; mRNA.
DR   IPI; IPI00219025; -.
DR   PIR; S68701; S47472.
DR   RefSeq; NP_001112362.1; NM_001118890.1.
DR   RefSeq; NP_002055.1; NM_002064.2.
DR   UniGene; Hs.28988; -.
DR   UniGene; Hs.712696; -.
DR   PDB; 1B4Q; NMR; -; A=2-106.
DR   PDB; 1JHB; NMR; -; A=1-106.
DR   PDBsum; 1B4Q; -.
DR   PDBsum; 1JHB; -.
DR   ProteinModelPortal; P35754; -.
DR   SMR; P35754; 2-106.
DR   STRING; P35754; -.
DR   UCD-2DPAGE; P35754; -.
DR   PeptideAtlas; P35754; -.
DR   PRIDE; P35754; -.
DR   Ensembl; ENST00000237858; ENSP00000237858; ENSG00000173221.
DR   Ensembl; ENST00000379979; ENSP00000369314; ENSG00000173221.
DR   Ensembl; ENST00000448201; ENSP00000404762; ENSG00000173221.
DR   GeneID; 2745; -.
DR   KEGG; hsa:2745; -.
DR   UCSC; uc003kln.2; human.
DR   CTD; 2745; -.
DR   GeneCards; GC05M090339; -.
DR   H-InvDB; HIX0005047; -.
DR   HGNC; HGNC:4330; GLRX.
DR   HPA; CAB008634; -.
DR   MIM; 600443; gene.
DR   neXtProt; NX_P35754; -.
DR   PharmGKB; PA28731; -.
DR   eggNOG; prNOG20908; -.
DR   GeneTree; ENSGT00390000003677; -.
DR   InParanoid; P35754; -.
DR   OMA; TNAIQDY; -.
DR   OrthoDB; EOG4N8R6D; -.
DR   PhylomeDB; P35754; -.
DR   BioCyc; MetaCyc:MONOMER-15195; -.
DR   Reactome; REACT_1698; Metabolism of nucleotides.
DR   DrugBank; DB00143; Glutathione.
DR   NextBio; 10820; -.
DR   ArrayExpress; P35754; -.
DR   Bgee; P35754; -.
DR   CleanEx; HS_GLRX; -.
DR   Genevestigator; P35754; -.
DR   GermOnline; ENSG00000173221; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:UniProtKB.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0015038; F:glutathione disulfide oxidoreductase activity; EXP:Reactome.
DR   GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0015949; P:nucleobase, nucleoside and nucleotide interconversion; TAS:Reactome.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011767; GLR_AS.
DR   InterPro; IPR002109; Glutaredoxin.
DR   InterPro; IPR011899; Glutaredoxin_euk/vir.
DR   InterPro; IPR014025; Glutaredoxin_subgr.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF00462; Glutaredoxin; 1.
DR   PRINTS; PR00160; GLUTAREDOXIN.
DR   SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR   TIGRFAMs; TIGR02180; GRX_euk; 1.
DR   PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
DR   HOGENOMDNA; HS5.PE1662; -.
KW   ENSG000001732211755old_1320000031; ENSP000003693147901old_1320000031;
KW   D3DQK5_HUMAN; AF069668; AF115104; AF115105; AF162769; AK311868; BC005304;
KW   BC106075; BT006689; CH471062; CH471084; CR450312; CR542165; D21238;
KW   X76648;
KW   3D-structure; Acetylation; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Disulfide bond; Electron transport;
KW   Polymorphism; Redox-active center; Reference proteome; Transport.
SQ   SEQUENCE   106 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY
     LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
//

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