(data stored in ACNUC9435 zone)

HOGENOM: HS5_PE2567

ID   HS5_PE2567                           STANDARD;      PRT;   543 AA.
AC   HS5_PE2567; P18146;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Early growth response protein 1; Short=EGR-1;AltName:
DE   Full=AT225;AltName: Full=Nerve growth factor-induced protein A;
DE   Short=NGFI-A;AltName: Full=Transcription factor ETR103;AltName:
DE   Full=Transcription factor Zif268;AltName: Full=Zinc finger protein
DE   225;AltName: Full=Zinc finger protein Krox-24; (HS5.PE2567).
GN   Name=EGR1; Synonyms=KROX24, ZNF225;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE2567.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:EGR1_HUMAN
CC   -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
CC       DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the
CC       transcription of target genes whose products are required for
CC       mitogenesis and differentiation.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: By growth factors.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- GENE_FAMILY: HOG000036856 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000120738;ENST00000239938;ENSP00000239938.
DR   EMBL; AJ243425; - ;
DR   EMBL; AK301065; - ;
DR   EMBL; BC073983; - ;
DR   EMBL; CH471062; - ;
DR   EMBL; M62829; - ;
DR   EMBL; M80583; - ;
DR   EMBL; X52541; - ;
DR   UniProtKB/Swiss-Prot; P18146; -.
DR   EMBL; X52541; CAA36777.1; -; mRNA.
DR   EMBL; M62829; AAA35815.1; -; mRNA.
DR   EMBL; M80583; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC073983; AAH73983.1; -; mRNA.
DR   IPI; IPI00030227; -.
DR   PIR; A41211; A41211.
DR   RefSeq; NP_001955.1; NM_001964.2.
DR   UniGene; Hs.326035; -.
DR   UniGene; Hs.708393; -.
DR   ProteinModelPortal; P18146; -.
DR   SMR; P18146; 332-449.
DR   IntAct; P18146; 3.
DR   MINT; MINT-234136; -.
DR   STRING; P18146; -.
DR   PhosphoSite; P18146; -.
DR   PRIDE; P18146; -.
DR   Ensembl; ENST00000239938; ENSP00000239938; ENSG00000120738.
DR   GeneID; 1958; -.
DR   KEGG; hsa:1958; -.
DR   UCSC; uc003ldb.1; human.
DR   CTD; 1958; -.
DR   GeneCards; GC05P132991; -.
DR   H-InvDB; HIX0200787; -.
DR   HGNC; HGNC:3238; EGR1.
DR   HPA; CAB019427; -.
DR   MIM; 128990; gene.
DR   neXtProt; NX_P18146; -.
DR   PharmGKB; PA27673; -.
DR   eggNOG; prNOG15341; -.
DR   InParanoid; P18146; -.
DR   OMA; SCAVPSN; -.
DR   OrthoDB; EOG4BP1BT; -.
DR   PhylomeDB; P18146; -.
DR   Pathway_Interaction_DB; nfat_tfpathway; Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
DR   Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells.
DR   Pathway_Interaction_DB; ar_tf_pathway; Regulation of Androgen receptor activity.
DR   Pathway_Interaction_DB; prlsignalingeventspathway; Signaling events mediated by PRL.
DR   Pathway_Interaction_DB; pi3kplctrkpathway; Trk receptor signaling mediated by PI3K and PLC-gamma.
DR   Pathway_Interaction_DB; mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
DR   Reactome; REACT_6900; Immune System.
DR   NextBio; 7943; -.
DR   ArrayExpress; P18146; -.
DR   Bgee; P18146; -.
DR   CleanEx; HS_EGR1; -.
DR   CleanEx; HS_ZNF225; -.
DR   Genevestigator; P18146; -.
DR   GermOnline; ENSG00000120738; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IPI:BHF-UCL.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071504; P:cellular response to heparin; ISS:UniProtKB.
DR   GO; GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
DR   GO; GO:0072110; P:glomerular mesangial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0072303; P:positive regulation of glomerular metanephric mesangial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
DR   GO; GO:0033233; P:regulation of protein sumoylation; IDA:BHF-UCL.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:BHF-UCL.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
DR   InterPro; IPR021839; DUF3432.
DR   InterPro; IPR021849; DUF3446.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF11914; DUF3432; 2.
DR   Pfam; PF11928; DUF3446; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; HS5.PE2567; -.
KW   ENSG000001207381755old_1320000031; ENSP000002399387901old_1320000031;
KW   B4DVG0_HUMAN; Q546S1_HUMAN; AJ243425; AK301065; BC073983; CH471062;
KW   M80583; X52541;
KW   Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Polymorphism; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   543 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGAPEGSGS
     NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL TAESFPDISL NNEKVLVETS
     YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS
     SASASQSPPL SCAVPSNDSS PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY
     PAAKGGFQVP MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG
     SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS RSDELTRHIR
     IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI CGRKFARSDE RKRHTKIHLR
     QKDKKADKSV VASSATSSLS SYPSPVATSY PSPVTTSYPS PATTSYPSPV PTSFSSPGSS
     TYPSPVHSGF PSPSVATTYS SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI
     EIC
//

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