(data stored in ACNUC13767 zone)

HOGENOM: HS5_PE4262

ID   HS5_PE4262                           STANDARD;      PRT;   682 AA.
AC   HS5_PE4262; O94808; Q53XM2; Q9BWS4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Glucosamine--fructose-6-phosphate aminotransferase
DE   (HS5.PE4262) [isomerizing] 2; EC=2.6.1 16;AltName:
DE   Full=D-fructose-6-phosphate amidotransferase 2;AltName:
DE   Full=Glutamine:fructose 6 phosphate amidotransferase 2; Short=GFAT 2;
DE   Short=GFAT2;AltName: Full=Hexosephosphate aminotransferase 2; .
GN   Name=GFPT2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE4262.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GFPT2_HUMAN
CC   -!- FUNCTION: Controls the flux of glucose into the hexosamine
CC       pathway. Most likely involved in regulating the availability of
CC       precursors for N- and O-linked glycosylation of proteins.
CC   -!- CATALYTIC ACTIVITY: L-glutamine + D-fructose 6-phosphate = L-
CC       glutamate + D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC       glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC       fructose 6-phosphate: step 1/1.
CC   -!- TISSUE SPECIFICITY: Highest levels of expression in heart,
CC       placenta, and spinal cord.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-2 domain.
CC   -!- SIMILARITY: Contains 2 SIS domains.
CC   -!- GENE_FAMILY: HOG000258898 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000131459;ENST00000253778;ENSP00000253778.
DR   EMBL; AB016789; - ;
DR   EMBL; AK001242; - ;
DR   EMBL; AK022507; - ;
DR   EMBL; AK297750; - ;
DR   EMBL; AK314551; - ;
DR   EMBL; BC000012; - ;
DR   EMBL; BT009818; - ;
DR   UniProtKB/Swiss-Prot; O94808; Q53XM2; Q9BWS4; -.
DR   EMBL; AB016789; BAA74731.1; -; mRNA.
DR   EMBL; BT009818; AAP88820.1; -; mRNA.
DR   EMBL; BC000012; AAH00012.1; -; mRNA.
DR   IPI; IPI00216159; -.
DR   RefSeq; NP_005101.1; NM_005110.2.
DR   UniGene; Hs.696497; -.
DR   ProteinModelPortal; O94808; -.
DR   SMR; O94808; 2-682.
DR   STRING; O94808; -.
DR   MEROPS; C44.972; -.
DR   PhosphoSite; O94808; -.
DR   PRIDE; O94808; -.
DR   Ensembl; ENST00000253778; ENSP00000253778; ENSG00000131459.
DR   GeneID; 9945; -.
DR   KEGG; hsa:9945; -.
DR   UCSC; uc003mlw.1; human.
DR   CTD; 9945; -.
DR   GeneCards; GC05M174452; -.
DR   H-InvDB; HIX0005496; -.
DR   HGNC; HGNC:4242; GFPT2.
DR   MIM; 603865; gene.
DR   neXtProt; NX_O94808; -.
DR   PharmGKB; PA28652; -.
DR   eggNOG; prNOG06885; -.
DR   GeneTree; ENSGT00390000010049; -.
DR   InParanoid; O94808; -.
DR   OMA; YNNISSH; -.
DR   OrthoDB; EOG4DV5KT; -.
DR   PhylomeDB; O94808; -.
DR   Reactome; REACT_17015; Metabolism of proteins.
DR   DrugBank; DB00130; L-Glutamine.
DR   NextBio; 37520; -.
DR   ArrayExpress; O94808; -.
DR   Bgee; O94808; -.
DR   CleanEx; HS_GFPT2; -.
DR   Genevestigator; O94808; -.
DR   GermOnline; ENSG00000131459; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; TAS:Reactome.
DR   GO; GO:0005529; F:sugar binding; IEA:InterPro.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; EXP:Reactome.
DR   GO; GO:0006112; P:energy reserve metabolic process; TAS:ProtInc.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; TAS:ProtInc.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
DR   GO; GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:Reactome.
DR   InterPro; IPR000583; GATase_2.
DR   InterPro; IPR017932; GATase_II.
DR   InterPro; IPR005855; GlmS_trans.
DR   InterPro; IPR001347; SIS.
DR   Pfam; PF00310; GATase_2; 2.
DR   Pfam; PF01380; SIS; 2.
DR   TIGRFAMs; TIGR01135; GlmS; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
DR   PROSITE; PS51464; SIS; 2.
DR   HOGENOMDNA; HS5.PE4262; -.
KW   ENSG000001314591755old_1320000031; ENSP000002537787901old_1320000031;
KW   B2RB90_HUMAN; B3KM63_HUMAN; B3KMR8_HUMAN; B4DN38_HUMAN; AB016789;
KW   AK022507; AK297750; AK314551; BC000012; BT009818;
KW   Aminotransferase; Complete proteome; Glutamine amidotransferase;
KW   Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase.
SQ   SEQUENCE   682 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNHEVK ERHIQLVKKR
     GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS AVNSHPQRSD KGNEFVVIHN
     GIITNYKDLR KFLESKGYEF ESETDTETIA KLIKYVFDNR ETEDITFSTL VERVIQQLEG
     AFALVFKSVH YPGEAVATRR GSPLLIGVRS KYKLSTEQIP ILYRTCTLEN VKNICKTRMK
     RLDSSACLHA VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS
     DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN TVLLGGLKDH
     LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE LASDFLDRNT PVFRDDVCFF
     ISQSGETADT LLALRYCKDR GALTVGVTNT VGSSISRETD CGVHINAGPE IGVASTKAYT
     SQFISLVMFG LMMSEDRISL QNRRQEIIRG LRSLPELIKE VLSLEEKIHD LALELYTQRS
     LLVMGRGYNY ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF
     AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH
     LAVLRGYDVD FPRNLAKSVT VE
//

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