(data stored in ACNUC4482 zone)

HOGENOM: HS5_PE692

ID   HS5_PE692                            STANDARD;      PRT;   1181 AA.
AC   HS5_PE692; P17301; Q14595;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Integrin alpha-2;AltName: Full=CD49 antigen-like family
DE   member B;AltName: Full=Collagen receptor;AltName: Full=Platelet membrane
DE   glycoprotein Ia; Short=GPIa;AltName: Full=VLA-2 subunit alpha;AltName:
DE   CD_antigen=CD49b;Flags: Precursor; (HS5.PE692).
GN   Name=ITGA2; Synonyms=CD49B;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS5.PE692.
CC       Homo sapiens chromosome 5 GRCh37  sequence 1..180905260 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ITA2_HUMAN
CC   -!- FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin,
CC       collagen, collagen C-propeptides, fibronectin and E-cadherin. It
CC       recognizes the proline-hydroxylated sequence G-F-P-G-E-R in
CC       collagen. It is responsible for adhesion of platelets and other
CC       cells to collagens, modulation of collagen and collagenase gene
CC       expression, force generation and organization of newly synthesized
CC       extracellular matrix.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2
CC       associates with beta-1. Interacts with HPS5 and RAB21. Binds to
CC       human echoviruses 1 and 8 capsid proteins and acts as a receptor
CC       for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A
CC       VP4; this interaction only occurs in rotavirus integrin-dependent
CC       strains, for which ITGA2 acts as a receptor.
CC   -!- INTERACTION:
CC       P35282:Rab21 (xeno); NbExp=7; IntAct=EBI-702960, EBI-1993555;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins
CC       with I-domains do not undergo protease cleavage.
CC   -!- POLYMORPHISM: Position 534 is associated with platelet-specific
CC       alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b)
CC       has Glu-534. HPA-5B is involved in neonatal alloimmune
CC       thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may
CC       play a role in coronary artery disease (CAD).
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC   -!- SIMILARITY: Contains 7 FG-GAP repeats.
CC   -!- SIMILARITY: Contains 1 VWFA domain.
CC   -!- WEB RESOURCE: Name=GeneReviews;
CC       URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGA2";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/itga2/";
CC   -!- GENE_FAMILY: HOG000059610 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000164171;ENST00000296585;ENSP00000296585.
DR   EMBL; AF035968; - ;
DR   EMBL; AF512556; - ;
DR   EMBL; L24121; - ;
DR   EMBL; X17033; - ;
DR   UniProtKB/Swiss-Prot; P17301; Q14595; -.
DR   EMBL; X17033; CAA34894.1; -; mRNA.
DR   EMBL; AF512556; AAM34795.1; -; Genomic_DNA.
DR   EMBL; L24121; AAA16619.2; -; Genomic_DNA.
DR   IPI; IPI00013744; -.
DR   PIR; A33998; A33998.
DR   RefSeq; NP_002194.2; NM_002203.3.
DR   UniGene; Hs.482077; -.
DR   PDB; 1AOX; X-ray; 2.10 A; A/B=169-366.
DR   PDB; 1DZI; X-ray; 2.10 A; A=172-355.
DR   PDB; 1PQB; Model; -; A/B=169-366.
DR   PDB; 1V7P; X-ray; 1.90 A; C=170-366.
DR   PDBsum; 1AOX; -.
DR   PDBsum; 1DZI; -.
DR   PDBsum; 1PQB; -.
DR   PDBsum; 1V7P; -.
DR   ProteinModelPortal; P17301; -.
DR   SMR; P17301; 169-366, 379-651, 1125-1163.
DR   DIP; DIP-67N; -.
DR   IntAct; P17301; 7.
DR   MINT; MINT-5004079; -.
DR   STRING; P17301; -.
DR   PhosphoSite; P17301; -.
DR   PRIDE; P17301; -.
DR   Ensembl; ENST00000296585; ENSP00000296585; ENSG00000164171.
DR   GeneID; 3673; -.
DR   KEGG; hsa:3673; -.
DR   UCSC; uc003joy.1; human.
DR   CTD; 3673; -.
DR   GeneCards; GC05P049257; -.
DR   H-InvDB; HIX0032121; -.
DR   HGNC; HGNC:6137; ITGA2.
DR   HPA; CAB017690; -.
DR   MIM; 192974; gene+phenotype.
DR   neXtProt; NX_P17301; -.
DR   Orphanet; 853; Fetal and neonatal alloimmune thrombocytopenia.
DR   PharmGKB; PA204; -.
DR   eggNOG; prNOG15734; -.
DR   InParanoid; P17301; -.
DR   OrthoDB; EOG45B1DV; -.
DR   Pathway_Interaction_DB; arf6_traffickingpathway; Arf6 trafficking events.
DR   Pathway_Interaction_DB; syndecan_2_pathway; Syndecan-2-mediated signaling events.
DR   Pathway_Interaction_DB; lymphangiogenesis_pathway; VEGFR3 signaling in lymphatic endothelium.
DR   Reactome; REACT_13552; Integrin cell surface interactions.
DR   Reactome; REACT_18266; Axon guidance.
DR   Reactome; REACT_604; Hemostasis.
DR   NextBio; 14377; -.
DR   ArrayExpress; P17301; -.
DR   Bgee; P17301; -.
DR   CleanEx; HS_ITGA2; -.
DR   Genevestigator; P17301; -.
DR   GermOnline; ENSG00000164171; Homo sapiens.
DR   GO; GO:0008305; C:integrin complex; TAS:ProtInc.
DR   GO; GO:0005518; F:collagen binding; TAS:ProtInc.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; TAS:Reactome.
DR   GO; GO:0007596; P:blood coagulation; TAS:Reactome.
DR   GO; GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
DR   GO; GO:0009887; P:organ morphogenesis; TAS:ProtInc.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR002035; VWF_A.
DR   Pfam; PF01839; FG-GAP; 1.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   HOGENOMDNA; HS5.PE692; -.
KW   ENSG000001641711755old_1320000031; ENSP000002965857901old_1320000031;
KW   Q71V33_HUMAN; AF035968; AF512556; L24121; X17033;
KW   3D-structure; Calcium; Cell adhesion; Complete proteome;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Host cell receptor for virus entry; Host-virus interaction; Integrin;
KW   Magnesium; Membrane; Phosphoprotein; Polymorphism; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   1181 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG
     NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT
     RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD
     ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS
     QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN
     HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ
     IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP
     KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ
     AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKEGILGQH
     QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY
     SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS
     FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN
     NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV
     FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG
     IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ
     NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI
     VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN
     ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW
     NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII
     AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S
//

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