(data stored in ACNUC15324 zone)

HOGENOM: HS6_PE2425

ID   HS6_PE2425                           STANDARD;      PRT;   163 AA.
AC   HS6_PE2425; Q96PD4; Q6NSI0; Q7Z6P4; Q96PI8; Q9NUE6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-17F; Short=IL-17F;AltName: Full=Cytokine
DE   ML-1;AltName: Full=Interleukin-24; Short=IL-24;Flags: Precursor;
DE   (HS6.PE2425).
GN   Name=IL17F; Synonyms=IL24;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS6.PE2425.
CC       Homo sapiens chromosome 6 GRCh37  sequence 1..171055067 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL17F_HUMAN
CC   -!- FUNCTION: Stimulates the production of other cytokines such as IL-
CC       6, IL-8 and granulocyte colony-stimulating factor, and can
CC       regulate cartilage matrix turnover. Stimulates PBMC and T-cell
CC       proliferation. Inhibits angiogenesis.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in activated, but not resting, CD4+
CC       T-cells and activated monocytes.
CC   -!- SIMILARITY: Belongs to the IL-17 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention;
CC       Sequence=CAD92646.1; Type=Erroneous gene model prediction;
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_17";
CC   -!- GENE_FAMILY: HOG000064520 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000112116;ENST00000336123;ENSP00000337432.
DR   EMBL; AF332389; - ;
DR   EMBL; AF384857; - ;
DR   EMBL; AL034343; - ;
DR   EMBL; BC070124; - ;
DR   UniProtKB/Swiss-Prot; Q96PD4; Q6NSI0; Q7Z6P4; Q96PI8; Q9NUE6; -.
DR   EMBL; AF384857; AAK83350.1; -; mRNA.
DR   EMBL; AL034343; CAD92646.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC070124; AAH70124.1; -; mRNA.
DR   EMBL; AF332389; AAL14427.1; ALT_SEQ; mRNA.
DR   IPI; IPI00791572; -.
DR   RefSeq; NP_443104.1; NM_052872.3.
DR   UniGene; Hs.272295; -.
DR   PDB; 1JPY; X-ray; 2.85 A; A/B/X/Y=31-163.
DR   PDB; 3JVF; X-ray; 3.30 A; A/B=31-163.
DR   PDBsum; 1JPY; -.
DR   PDBsum; 3JVF; -.
DR   ProteinModelPortal; Q96PD4; -.
DR   SMR; Q96PD4; 38-158.
DR   STRING; Q96PD4; -.
DR   PRIDE; Q96PD4; -.
DR   Ensembl; ENST00000336123; ENSP00000337432; ENSG00000112116.
DR   GeneID; 112744; -.
DR   KEGG; hsa:112744; -.
DR   UCSC; uc003pal.1; human.
DR   CTD; 112744; -.
DR   GeneCards; GC06M051932; -.
DR   H-InvDB; HIX0032794; -.
DR   HGNC; HGNC:16404; IL17F.
DR   MIM; 606496; gene.
DR   neXtProt; NX_Q96PD4; -.
DR   Orphanet; 1334; Chronic mucocutaneous candidiasis.
DR   PharmGKB; PA29800; -.
DR   GeneTree; ENSGT00530000063175; -.
DR   InParanoid; Q96PD4; -.
DR   OMA; SSSPWDY; -.
DR   OrthoDB; EOG4BG8XJ; -.
DR   PhylomeDB; Q96PD4; -.
DR   Pathway_Interaction_DB; il23pathway; IL23-mediated signaling events.
DR   ArrayExpress; Q96PD4; -.
DR   Bgee; Q96PD4; -.
DR   CleanEx; HS_IL17F; -.
DR   CleanEx; HS_IL24; -.
DR   Genevestigator; Q96PD4; -.
DR   GermOnline; ENSG00000112116; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IDA:UniProtKB.
DR   GO; GO:0019955; F:cytokine binding; IDA:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0051216; P:cartilage development; IDA:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0042109; P:lymphotoxin A biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IDA:UniProtKB.
DR   GO; GO:0006029; P:proteoglycan metabolic process; IDA:UniProtKB.
DR   GO; GO:0045423; P:regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; IDA:UniProtKDR   GO; GO:0045076; P:regulation of interleukin-2 biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0045076; P:regulation of interleukin-2 biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0045408; P:regulation of interleukin-6 biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0045414; P:regulation of interleukin-8 biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
DR   InterPro; IPR020440; Interleukin-17_chordata.
DR   InterPro; IPR010345; Interleukin-17_met.
DR   PANTHER; PTHR21295; IL17; 1.
DR   Pfam; PF06083; IL17; 1.
DR   PRINTS; PR01932; INTRLEUKIN17.
DR   HOGENOMDNA; HS6.PE2425; -.
KW   ENSG000001121161755old_1320000031; ENSP000003374327901old_1320000031;
KW   AF332389; AF384857; AL034343; BC070124;
KW   3D-structure; Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Polymorphism; Reference proteome;
KW   Secreted; Signal.
SQ   SEQUENCE   163 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTVKTLHGPA MVKYLLLSIL GLAFLSEAAA RKIPKVGHTF FQKPESCPPV PGGSMKLDIG
     IINENQRVSM SRNIESRSTS PWNYTVTWDP NRYPSEVVQA QCRNLGCINA QGKEDISMNS
     VPIQQETLVV RRKHQGCSVS FQLEKVLVTV GCTCVTPVIH HVQ
//

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