(data stored in ACNUC21562 zone)

HOGENOM: HS6_PE4180

ID   HS6_PE4180                           STANDARD;      PRT;   325 AA.
AC   HS6_PE4180; P04201; E1P5B3; Q2TBC9; Q6FG47;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Proto-oncogene Mas; (HS6.PE4180).
GN   Name=MAS1; Synonyms=MAS;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS6.PE4180.
CC       Homo sapiens chromosome 6 GRCh37  sequence 1..171055067 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MAS_HUMAN
CC   -!- FUNCTION: Receptor for angiotensin 1-7 (By similarity). Acts
CC       specifically as a functional antagonist of AGTR1 (angiotensin-2
CC       type 1 receptor), although it up-regulates AGTR1 receptor levels.
CC       Positive regulation of AGTR1 levels occurs through activation of
CC       the G-proteins GNA11 and GNAQ, and stimulation of the protein
CC       kinase C signaling cascade. The antagonist effect on AGTR1
CC       function is probably due to AGTR1 being physically altered by
CC       MAS1.
CC   -!- SUBUNIT: Interacts with AGTR1 (Probable).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- DISEASE: Note=The MAS oncogene has a weak focus-inducing activity
CC       in transfected NIH 3T3 cells.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC   -!- CAUTION: Was originally (PubMed:3419518) thought to be a receptor
CC       for angiotensin II.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000130368;ENST00000252660;ENSP00000252660.
DR   EMBL; AL035691; - ;
DR   EMBL; BC069142; - ;
DR   EMBL; BC069581; - ;
DR   EMBL; BC110454; - ;
DR   EMBL; CR542261; - ;
DR   EMBL; M13150; - ;
DR   UniProtKB/Swiss-Prot; P04201; E1P5B3; Q2TBC9; Q6FG47; -.
DR   EMBL; M13150; AAA36199.1; -; mRNA.
DR   EMBL; CR542261; CAG47057.1; -; mRNA.
DR   EMBL; AL035691; CAB72444.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47610.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47611.1; -; Genomic_DNA.
DR   EMBL; BC069142; AAH69142.1; -; mRNA.
DR   EMBL; BC069581; AAH69581.1; -; mRNA.
DR   EMBL; BC110454; AAI10455.1; -; mRNA.
DR   IPI; IPI00022860; -.
DR   PIR; A01375; TVHUAS.
DR   RefSeq; NP_002368.1; NM_002377.2.
DR   UniGene; Hs.99900; -.
DR   ProteinModelPortal; P04201; -.
DR   SMR; P04201; 118-148.
DR   STRING; P04201; -.
DR   PhosphoSite; P04201; -.
DR   PRIDE; P04201; -.
DR   Ensembl; ENST00000252660; ENSP00000252660; ENSG00000130368.
DR   GeneID; 4142; -.
DR   KEGG; hsa:4142; -.
DR   UCSC; uc003qsz.1; human.
DR   CTD; 4142; -.
DR   GeneCards; GC06P157798; -.
DR   H-InvDB; HIX0032929; -.
DR   HGNC; HGNC:6899; MAS1.
DR   HPA; HPA013564; -.
DR   MIM; 165180; gene.
DR   neXtProt; NX_P04201; -.
DR   PharmGKB; PA30643; -.
DR   eggNOG; prNOG18968; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   InParanoid; P04201; -.
DR   OMA; DEMQPRR; -.
DR   OrthoDB; EOG4SJ5F8; -.
DR   PhylomeDB; P04201; -.
DR   NextBio; 16268; -.
DR   ArrayExpress; P04201; -.
DR   Bgee; P04201; -.
DR   CleanEx; HS_MAS1; -.
DR   Genevestigator; P04201; -.
DR   GermOnline; ENSG00000130368; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0004945; F:angiotensin type II receptor activity; TAS:ProtInc.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR   GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR   GO; GO:0070528; P:protein kinase C signaling cascade; IMP:UniProtKB.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR000820; Mas_TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00533; MASONCOGENE.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; HS6.PE4180; -.
KW   ENSG000001303681755old_1320000031; ENSP000002526607901old_1320000031;
KW   AL035691; BC069142; BC069581; BC110454; CR542261; M13150;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Proto-oncogene; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   325 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN GILLWFLCFR
     MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG HYYTIVTLSV TFLFGYNTGL
     YLLTAISVER CLSVLYPIWY RCHRPKYQSA LVCALLWALS CLVTTMEYVM CIDREEESHS
     RNDCRAVIIF IAILSFLVFT PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF
     AMPMRLLYLL YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT
     RAFKDEMQPR RQKDNCNTVT VETVV
//

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