(data stored in ACNUC9543 zone)

HOGENOM: HS6_PE862

ID   HS6_PE862                            STANDARD;      PRT;   1041 AA.
AC   HS6_PE862; O60231; O60322; Q5JP45; Q969X7; Q96QC1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA
DE   helicase DHX16; EC=3.6.4 13;AltName: Full=ATP-dependent RNA helicase
DE   #3;AltName: Full=DEAH-box protein 16; (HS6.PE862).
GN   Name=DHX16; Synonyms=DBP2, DDX16, KIAA0577;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS6.PE862.
CC       Homo sapiens chromosome 6 GRCh37  sequence 1..171055067 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DHX16_HUMAN
CC   -!- FUNCTION: Probable ATP-binding RNA helicase involved in pre-mRNA
CC       splicing.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX16/PRP8 sub-subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25503.2; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000175261 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000204560;ENST00000376442;ENSP00000365625.
DR   EMBL; AB001601; - ;
DR   EMBL; AB011149; - ;
DR   EMBL; AB088098; - ;
DR   EMBL; AB103604; - ;
DR   EMBL; AB202095; - ;
DR   EMBL; AK302721; - ;
DR   EMBL; AK312264; - ;
DR   EMBL; AL662798; - ;
DR   EMBL; AL732442; - ;
DR   EMBL; AL845353; - ;
DR   EMBL; BA000025; - ;
DR   EMBL; BC002789; - ;
DR   EMBL; BC008825; - ;
DR   EMBL; BC009392; - ;
DR   EMBL; BX119957; - ;
DR   EMBL; BX908728; - ;
DR   EMBL; CH471081; - ;
DR   EMBL; CR753328; - ;
DR   EMBL; CR759778; - ;
DR   EMBL; CR759873; - ;
DR   EMBL; CR788240; - ;
DR   EMBL; CU013522; - ;
DR   UniProtKB/Swiss-Prot; O60231; O60322; Q5JP45; Q969X7; Q96QC1; -.
DR   EMBL; AB001601; BAA25908.1; -; mRNA.
DR   EMBL; BA000025; BAB63323.1; -; Genomic_DNA.
DR   EMBL; AB011149; BAA25503.2; ALT_INIT; mRNA.
DR   EMBL; AL845353; CAI41883.1; -; Genomic_DNA.
DR   EMBL; BC008825; AAH08825.1; -; mRNA.
DR   EMBL; BC009392; AAH09392.1; -; mRNA.
DR   IPI; IPI00552073; -.
DR   RefSeq; NP_001157711.1; NM_001164239.1.
DR   RefSeq; NP_003578.2; NM_003587.4.
DR   UniGene; Hs.485060; -.
DR   ProteinModelPortal; O60231; -.
DR   SMR; O60231; 388-1032.
DR   IntAct; O60231; 3.
DR   MINT; MINT-5003862; -.
DR   STRING; O60231; -.
DR   PhosphoSite; O60231; -.
DR   PRIDE; O60231; -.
DR   Ensembl; ENST00000376442; ENSP00000365625; ENSG00000204560.
DR   Ensembl; ENST00000383577; ENSP00000373071; ENSG00000206486.
DR   Ensembl; ENST00000417308; ENSP00000390938; ENSG00000233561.
DR   Ensembl; ENST00000421095; ENSP00000396193; ENSG00000226171.
DR   Ensembl; ENST00000424672; ENSP00000389862; ENSG00000233418.
DR   Ensembl; ENST00000451456; ENSP00000408956; ENSG00000233049.
DR   Ensembl; ENST00000458094; ENSP00000393958; ENSG00000231377.
DR   GeneID; 8449; -.
DR   KEGG; hsa:8449; -.
DR   CTD; 8449; -.
DR   GeneCards; GC06M030391; -.
DR   GeneCards; GC06Mn30610; -.
DR   HGNC; HGNC:2739; DHX16.
DR   MIM; 603405; gene.
DR   neXtProt; NX_O60231; -.
DR   InParanoid; O60231; -.
DR   OMA; LHREFLS; -.
DR   OrthoDB; EOG4VHK5Q; -.
DR   PhylomeDB; O60231; -.
DR   NextBio; 31614; -.
DR   CleanEx; HS_DHX16; -.
DR   Genevestigator; O60231; -.
DR   GermOnline; ENSG00000204560; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; TAS:ProtInc.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; TAS:ProtInc.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   HOGENOMDNA; HS6.PE862; -.
KW   ENSG000002045601755old_1320000031; ENSP000003656257901old_1320000031;
KW   B0V0F8_HUMAN; B4DZ28_HUMAN; Q5SQH4_HUMAN; Q6PKC8_HUMAN; AB001601;
KW   AB088098; AB103604; AB202095; AK302721; AK312264; AL662798; AL732442;
KW   BA000025; BC002789; BC008825; BC009392; BX119957; BX908728; CH471081;
KW   CR759778; CR759873; CR788240; CU013522;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Polymorphism; Reference proteome.
SQ   SEQUENCE   1041 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCTSA EEFVQRLRDT DTLDLSGPAR
     DFALRLWNKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL EDSEESSEET VSRAGSSLQK
     KRKKRKHLRK KREEEEEEEA SEKGKKKTGG SKQQTEKPES EDEWERTERE RLQDLEERDA
     FAERVRQRDK DRTRNVLERS DKKAYEEAQK RLKMAEEDRK AMVPELRKKS RREYLAKRER
     EKLEDLEAEL ADEEFLFGDV ELSRHERQEL KYKRRVRDLA REYRAAGEQE KLEATNRYHM
     PKETRGQPAR AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE PKYQLVLEEE
     ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP VFPFREELLA AIANHQVLII
     EGETGSGKTT QIPQYLFEEG YTNKGMKIAC TQPRRVAAMS VAARVAREMG VKLGNEVGYS
     IRFEDCTSER TVLRYMTDGM LLREFLSEPD LASYSVVMVD EAHERTLHTD ILFGLIKDVA
     RFRPELKVLV ASATMDTARF STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL
     QIHVTQPPGD ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN LPSDMQARIF
     QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY NPRTGMESLT VTPCSKASAN
     QRAGRAGRVA AGKCFRLYTA WAYQHELEET TVPEIQRTSL GNVVLLLKSL GIHDLMHFDF
     LDPPPYETLL LALEQLYALG ALNHLGELTT SGRKMAELPV DPMLSKMILA SEKYSCSEEI
     LTVAAMLSVN NSIFYRPKDK VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE
     NFVQFRSMRR ARDVREQLEG LLERVEVGLS SCQGDYIRVR KAITAGYFYH TARLTRSGYR
     TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV LEIESSWLLE VAPHYYKAKE
     LEDPHAKKMP KKIGKTREEL G
//

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