(data stored in ACNUC15234 zone)

HOGENOM: HS7_PE1372

ID   HS7_PE1372                           STANDARD;      PRT;   1562 AA.
AC   HS7_PE1372; O15069;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=NAC-alpha domain-containing protein 1; (HS7.PE1372).
GN   Name=NACAD; Synonyms=KIAA0363;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS7.PE1372.
CC       Homo sapiens chromosome 7 GRCh37  sequence 1..159128663 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:NACAD_HUMAN
CC   -!- FUNCTION: May prevent inappropriate targeting of non-secretory
CC       polypeptides to the endoplasmic reticulum (ER). May bind to
CC       nascent polypeptide chains as they emerge from the ribosome and
CC       block their interaction with the signal recognition particle
CC       (SRP), which normally targets nascent secretory peptides to the
CC       ER. May also reduce the inherent affinity of ribosomes for protein
CC       translocation sites in the ER membrane (M sites) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the NAC-alpha family.
CC   -!- SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain.
CC   -!- GENE_FAMILY: HOG000113723 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000136274;ENST00000490531;ENSP00000420477.
DR   EMBL; AB002361; - ;
DR   EMBL; AC013416; - ;
DR   UniProtKB/Swiss-Prot; O15069; -.
DR   EMBL; AC013416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB002361; BAA20818.1; -; mRNA.
DR   IPI; IPI00929627; -.
DR   RefSeq; NP_001139806.1; NM_001146334.1.
DR   UniGene; Hs.96633; -.
DR   ProteinModelPortal; O15069; -.
DR   SMR; O15069; 1420-1560.
DR   PhosphoSite; O15069; -.
DR   PRIDE; O15069; -.
DR   Ensembl; ENST00000258775; ENSP00000258775; ENSG00000136274.
DR   GeneID; 23148; -.
DR   KEGG; hsa:23148; -.
DR   UCSC; uc003tmt.1; human.
DR   CTD; 23148; -.
DR   GeneCards; GC07M045004; -.
DR   H-InvDB; HIX0006663; -.
DR   HGNC; HGNC:22196; NACAD.
DR   neXtProt; NX_O15069; -.
DR   PharmGKB; PA162396706; -.
DR   eggNOG; prNOG16779; -.
DR   GeneTree; ENSGT00440000033468; -.
DR   InParanoid; O15069; -.
DR   OMA; EAPECPE; -.
DR   PhylomeDB; O15069; -.
DR   ArrayExpress; O15069; -.
DR   Bgee; O15069; -.
DR   CleanEx; HS_NACAD; -.
DR   Genevestigator; O15069; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx.
DR   Pfam; PF01849; NAC; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
DR   HOGENOMDNA; HS7.PE1372; -.
KW   ENSG000001362741755old_1320000031; ENSP000004204777901old_1320000031;
KW   AB002361; AC013416;
KW   Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism;
KW   Protein transport; Reference proteome; Transport.
SQ   SEQUENCE   1562 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPGEAARAEL LLPEADRPGP RTDLSCDAAA ATTILGGDRR EPCALTPGPS HLALTFLPSK
     PGARPQPEGA SWDAGPGGAP SAWADPGEGG PSPMLLPEGL SSQALSTEAP LPATLEPRIV
     MGEETCQALL SPRAARTALR DQEGGHASPD PPPELCSQGD LSVPSPPPDP DSFFTPPSTP
     TKTTYALLPA CGPHGDARDS EAELRDELLD SPPASPSGSY ITADGDSWAS SPSCSLSLLA
     PAEGLDFPSG WGLSPQGSMV DERELHPAGT PEPPSSESSL SADSSSSWGQ EGHFFDLDFL
     ANDPMIPAAL LPFQGSLIFQ VEAVEVTPLS PEEEEEEAVA DPDPGGDLAG EGEEDSTSAS
     FLQSLSDLSI TEGMDEAFAF RDDTSAASSD SDSASYAEAD DERLYSGEPH AQATLLQDSV
     QKTEEESGGG AKGLQAQDGT VSWAVEAAPQ TSDRGAYLSQ RQELISEVTE EGLALGQEST
     ATVTPHTLQV APGLQVEVAT RVTPQAGEEE TDSTAGQESA AMAMPQPSQE GISEILGQES
     VTAEKLPTPQ EETSLTLCPD SPQNLKEEGG LDLPSGRKPV AAATIVPRQA KEDLTLPQDS
     AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS VMTPPLPLQD TELSSAPKPV
     AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS
     AMTPPLPLQD TDLSSAPKPV AAATLVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV
     AAATIVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV AAATIVSQQA EEGLTLPQDS
     AMTPPLPLQD TDLSSAPKPV AAATPVSQQA EEGLTLPQDS AMTPPLPLQD TDLSSAPKPV
     AAATPVSQQA EEGLTLPQDS AMTAPLPLQD TGPTSGPEPL AVATPQTLQA EAGCAPGTEP
     VATMAQQEVG EALGPRPAPE EKNAALPTVP EPAALDQVQQ DDPQPAAEAG TPWAAQEDAD
     STLGMEALSL PEPASGAGEE IAEALSRPGR EACLEARAHT GDGAKPDSPQ KETLEVENQQ
     EGGLKPLAQE HGPRSALGGA REVPDAPPAA CPEVSQARLL SPAREERGLS GKSTPEPTLP
     SAVATEASLD SCPESSVGAV SSLDRGCPDA PAPTSAPTSQ QPEPVLGLGS VEQPHEVPSV
     LGTPLLQPPE NLAKGQPSTP VDRPLGPDPS APGTLAGAAL PPLEPPAPCL CQDPQEDSVE
     DEEPPGSLGL PPPQAGVQPA AAAVSGTTQP LGTGPRVSLS PHSPLLSPKV ASMDAKDLAL
     QILPPCQVPP PSGPQSPAGP QGLSAPEQQE DEDSLEEDSP RALGSGQHSD SHGESSAELD
     EQDILAPQTV QCPAQAPAGG SEETIAKAKQ SRSEKKARKA MSKLGLRQIQ GVTRITIQKS
     KNILFVIAKP DVFKSPASDT YVVFGEAKIE DLSQQVHKAA AEKFKVPSEP SALVPESAPR
     PRVRLECKEE EEEEEEEVDE AGLELRDIEL VMAQANVSRA KAVRALRDNH SDIVNAIMEL
     TM
//

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