(data stored in ACNUC10964 zone)

HOGENOM: HS7_PE149

ID   HS7_PE149                            STANDARD;      PRT;   465 AA.
AC   HS7_PE149; Q9Y5X2; A4D207; Q96I67;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Sorting nexin-8; (HS7.PE149).
GN   Name=SNX8;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS7.PE149.
CC       Homo sapiens chromosome 7 GRCh37  sequence 1..159128663 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SNX8_HUMAN
CC   -!- FUNCTION: May be involved in several stages of intracellular
CC       trafficking. May play a role in intracellular protein transport
CC       from early endosomes to the trans-Golgi network.
CC   -!- INTERACTION:
CC       P16333:NCK1; NbExp=2; IntAct=EBI-1752557, EBI-389883;
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane
CC       protein; Cytoplasmic side. Note=Colocalizes with retromer
CC       components.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC   -!- SIMILARITY: Contains 1 PX (phox homology) domain.
CC   -!- GENE_FAMILY: HOG000252992 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000106266;ENST00000222990;ENSP00000222990.
DR   EMBL; AC004971; - ;
DR   EMBL; AF121858; - ;
DR   EMBL; AK315670; - ;
DR   EMBL; BC007785; - ;
DR   EMBL; BC021565; - ;
DR   EMBL; CH236953; - ;
DR   EMBL; CH471144; - ;
DR   UniProtKB/Swiss-Prot; Q9Y5X2; A4D207; Q96I67; -.
DR   EMBL; AF121858; AAD27831.1; -; mRNA.
DR   EMBL; CH236953; EAL23950.1; -; Genomic_DNA.
DR   EMBL; CH471144; EAW87235.1; -; Genomic_DNA.
DR   EMBL; BC007785; AAH07785.2; -; mRNA.
DR   EMBL; BC021565; AAH21565.1; -; mRNA.
DR   IPI; IPI00001885; -.
DR   RefSeq; NP_037453.1; NM_013321.2.
DR   UniGene; Hs.584900; -.
DR   ProteinModelPortal; Q9Y5X2; -.
DR   SMR; Q9Y5X2; 90-179.
DR   IntAct; Q9Y5X2; 5.
DR   MINT; MINT-3087539; -.
DR   STRING; Q9Y5X2; -.
DR   PhosphoSite; Q9Y5X2; -.
DR   PRIDE; Q9Y5X2; -.
DR   Ensembl; ENST00000222990; ENSP00000222990; ENSG00000106266.
DR   GeneID; 29886; -.
DR   KEGG; hsa:29886; -.
DR   UCSC; uc003slw.1; human.
DR   CTD; 29886; -.
DR   GeneCards; GC07M002261; -.
DR   H-InvDB; HIX0006429; -.
DR   HGNC; HGNC:14972; SNX8.
DR   neXtProt; NX_Q9Y5X2; -.
DR   PharmGKB; PA37948; -.
DR   GeneTree; ENSGT00460000041594; -.
DR   InParanoid; Q9Y5X2; -.
DR   OMA; LYCLHQE; -.
DR   OrthoDB; EOG42JNRD; -.
DR   PhylomeDB; Q9Y5X2; -.
DR   NextBio; 52423; -.
DR   ArrayExpress; Q9Y5X2; -.
DR   Bgee; Q9Y5X2; -.
DR   CleanEx; HS_SNX8; -.
DR   Genevestigator; Q9Y5X2; -.
DR   GermOnline; ENSG00000106266; Homo sapiens.
DR   GO; GO:0031901; C:early endosome membrane; IDA:UniProtKB.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IMP:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   GO; GO:0034498; P:early endosome to Golgi transport; IMP:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IMP:UniProtKB.
DR   InterPro; IPR001683; Phox.
DR   Gene3D; G3DSA:3.30.1520.10; PX; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX; 1.
DR   PROSITE; PS50195; PX; 1.
DR   HOGENOMDNA; HS7.PE149; -.
KW   ENSG000001062661755old_1320000031; ENSP000002229907901old_1320000031;
KW   B2RDT8_HUMAN; C9IYC5_HUMAN; C9J014_HUMAN; C9J8E6_HUMAN; C9JCB9_HUMAN;
KW   AF121858; AK315670; BC007785; BC021565; CH236953; CH471144;
KW   Complete proteome; Endosome; Lipid-binding; Membrane; Phosphoprotein;
KW   Polymorphism; Protein transport; Reference proteome; Transport.
SQ   SEQUENCE   465 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN
     PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML
     LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS
     DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE
     RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD
     KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT
     AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN
     SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH
//

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