(data stored in ACNUC10243 zone)

HOGENOM: HS7_PE729

ID   HS7_PE729                            STANDARD;      PRT;   353 AA.
AC   HS7_PE729; P22626; A8K064; P22627; Q9UC98; Q9UDJ2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoproteins A2/B1; Short=hnRNP
DE   A2/B1; (HS7.PE729).
GN   Name=HNRNPA2B1; Synonyms=HNRPA2B1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS7.PE729.
CC       Homo sapiens chromosome 7 GRCh37  sequence 1..159128663 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA2_HUMAN
CC   -!- FUNCTION: Involved with pre-mRNA processing. Forms complexes
CC       (ribonucleosomes) with at least 20 other different hnRNP and
CC       heterogeneous nuclear RNA in the nucleous.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with IGF2BP1.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm.
CC       Note=Localized in cytoplasmic mRNP granules containing
CC       untranslated mRNAs. Component of ribonucleosomes. Predominantly
CC       nucleoplasmic, however isoform A2 is also found in the cytoplasm
CC       of cells in some tissues. Not found in the nucleolus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B1;
CC         IsoId=P22626-1; Sequence=Displayed;
CC       Name=A2;
CC         IsoId=P22626-2; Sequence=VSP_005830;
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000122566;ENST00000354667;ENSP00000346694.
DR   EMBL; AK289429; - ;
DR   EMBL; D28877; - ;
DR   EMBL; M29064; - ;
DR   EMBL; M29065; - ;
DR   EMBL; U09120; - ;
DR   EMBL; U09121; - ;
DR   EMBL; U09122; - ;
DR   EMBL; U09123; - ;
DR   UniProtKB/Swiss-Prot; P22626; A8K064; P22627; Q9UC98; Q9UDJ2; -.
DR   EMBL; M29064; AAA60271.1; -; mRNA.
DR   EMBL; M29065; AAA36574.1; -; mRNA.
DR   EMBL; U09123; AAB60650.1; -; Genomic_DNA.
DR   EMBL; U09120; AAB60650.1; JOINED; Genomic_DNA.
DR   EMBL; U09121; AAB60650.1; JOINED; Genomic_DNA.
DR   EMBL; U09122; AAB60650.1; JOINED; Genomic_DNA.
DR   EMBL; D28877; BAA06031.1; -; Genomic_DNA.
DR   EMBL; D28877; BAA06032.1; -; Genomic_DNA.
DR   EMBL; AK289429; BAF82118.1; -; mRNA.
DR   IPI; IPI00396378; -.
DR   IPI; IPI00414696; -.
DR   PIR; A56845; B34504.
DR   RefSeq; NP_002128.1; NM_002137.3.
DR   RefSeq; NP_112533.1; NM_031243.2.
DR   UniGene; Hs.487774; -.
DR   PDB; 1X4B; NMR; -; A=1-103.
DR   PDBsum; 1X4B; -.
DR   ProteinModelPortal; P22626; -.
DR   SMR; P22626; 1-193.
DR   IntAct; P22626; 32.
DR   MINT; MINT-4998934; -.
DR   STRING; P22626; -.
DR   PhosphoSite; P22626; -.
DR   SWISS-2DPAGE; P22626; -.
DR   REPRODUCTION-2DPAGE; IPI00396378; -.
DR   REPRODUCTION-2DPAGE; IPI00414696; -.
DR   REPRODUCTION-2DPAGE; P22626; -.
DR   UCD-2DPAGE; P22626; -.
DR   PRIDE; P22626; -.
DR   Ensembl; ENST00000354667; ENSP00000346694; ENSG00000122566.
DR   Ensembl; ENST00000360787; ENSP00000354021; ENSG00000122566.
DR   GeneID; 3181; -.
DR   KEGG; hsa:3181; -.
DR   UCSC; uc003sxr.2; human.
DR   UCSC; uc003sxs.2; human.
DR   CTD; 3181; -.
DR   GeneCards; GC07M026197; -.
DR   H-InvDB; HIX0006534; -.
DR   HGNC; HGNC:5033; HNRNPA2B1.
DR   HPA; CAB012403; -.
DR   HPA; HPA001666; -.
DR   MIM; 600124; gene.
DR   neXtProt; NX_P22626; -.
DR   PharmGKB; PA162391140; -.
DR   eggNOG; prNOG19752; -.
DR   GeneTree; ENSGT00540000069937; -.
DR   OMA; EMQEVQN; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   PhylomeDB; P22626; -.
DR   Reactome; REACT_1675; mRNA Processing.
DR   Reactome; REACT_71; Gene Expression.
DR   NextBio; 12622; -.
DR   PMAP-CutDB; P22626; -.
DR   ArrayExpress; P22626; -.
DR   Bgee; P22626; -.
DR   CleanEx; HS_HNRNPA2B1; -.
DR   Genevestigator; P22626; -.
DR   GermOnline; ENSG00000122566; Homo sapiens.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; IDA:HGNC.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:HGNC.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IDA:HGNC.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IDA:HGNC.
DR   GO; GO:0050658; P:RNA transport; IDA:HGNC.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; HS7.PE729; -.
KW   ENSG000001225661755old_1320000031; ENSP000003466947901old_1320000031;
KW   AK289429; D28877; M29064; M29065; U09120; U09121; U09122; U09123;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasm; Direct protein sequencing; Methylation; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
SQ   SEQUENCE   353 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEKTLETVPL ERKKREKEQF RKLFIGGLSF ETTEESLRNY YEQWGKLTDC VVMRDPASKR
     SRGFGFVTFS SMAEVDAAMA ARPHSIDGRV VEPKRAVARE ESGKPGAHVT VKKLFVGGIK
     EDTEEHHLRD YFEEYGKIDT IEIITDRQSG KKRGFGFVTF DDHDPVDKIV LQKYHTINGH
     NAEVRKALSR QEMQEVQSSR SGRGGNFGFG DSRGGGGNFG PGPGSNFRGG SDGYGSGRGF
     GDGYNGYGGG PGGGNFGGSP GYGGGRGGYG GGGPGYGNQG GGYGGGYDNY GGGNYGSGNY
     NDFGNYNQQP SNYGPMKSGN FGGSRNMGGP YGGGNYGPGG SGGSGGYGGR SRY
//

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