(data stored in ACNUC3582 zone)

HOGENOM: HS8_PE1801

ID   HS8_PE1801                           STANDARD;      PRT;   871 AA.
AC   HS8_PE1801; Q8IWU6; Q86YV8; Q8NCA2; Q9UPS5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Extracellular sulfatase Sulf-1; Short=hSulf-1; EC=3.1.6
DE   -;Flags: Precursor; (HS8.PE1801).
GN   Name=SULF1; Synonyms=KIAA1077;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS8.PE1801.
CC       Homo sapiens chromosome 8 GRCh37  sequence 1..146304022 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SULF1_HUMAN
CC   -!- FUNCTION: Exhibits arylsulfatase activity and highly specific
CC       endoglucosamine-6-sulfatase activity. It can remove sulfate from
CC       the C-6 position of glucosamine within specific subregions of
CC       intact heparin. Diminishes HSPG (heparan sulfate proteoglycans)
CC       sulfation, inhibits signaling by heparin-dependent growth factors,
CC       diminishes proliferation, and facilitates apoptosis in response to
CC       exogenous stimulation.
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 7.0-8.0;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi
CC       apparatus, Golgi stack (By similarity). Cell surface (By
CC       similarity). Note=Also localized on the cell surface (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in testis,
CC       stomach, skeletal muscle, lung, kidney, pancreas, small intestine
CC       and colon. It is also detected in normal ovarian surface
CC       epithelial cells. Down-regulation seen in ovarian carcinoma cell
CC       lines, ovarian cancers, breast, pancreatic, renal and
CC       hepatocellular carcinoma cell lines.
CC   -!- PTM: The conversion to 3-oxoalanine (also known as C-
CC       formylglycine, FGly), of a serine or cysteine residue in
CC       prokaryotes and of a cysteine residue in eukaryotes, is critical
CC       for catalytic activity (By similarity).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC   -!- GENE_FAMILY: HOG000290161 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000137573;ENST00000458141;ENSP00000403040.
DR   EMBL; AB029000; - ;
DR   EMBL; AF545571; - ;
DR   EMBL; AK074873; - ;
DR   EMBL; AY101175; - ;
DR   EMBL; BC012997; - ;
DR   EMBL; BX571746; - ;
DR   UniProtKB/Swiss-Prot; Q8IWU6; Q86YV8; Q8NCA2; Q9UPS5; -.
DR   EMBL; AY101175; AAM76860.1; -; mRNA.
DR   EMBL; AF545571; AAO33315.1; -; mRNA.
DR   EMBL; AB029000; BAA83029.1; -; mRNA.
DR   EMBL; AK074873; BAC11258.1; -; mRNA.
DR   IPI; IPI00293203; -.
DR   RefSeq; NP_001121676.1; NM_001128204.1.
DR   RefSeq; NP_001121677.1; NM_001128205.1.
DR   RefSeq; NP_001121678.1; NM_001128206.1.
DR   RefSeq; NP_055985.2; NM_015170.2.
DR   UniGene; Hs.409602; -.
DR   ProteinModelPortal; Q8IWU6; -.
DR   SMR; Q8IWU6; 279-386.
DR   STRING; Q8IWU6; -.
DR   PRIDE; Q8IWU6; -.
DR   Ensembl; ENST00000260128; ENSP00000260128; ENSG00000137573.
DR   Ensembl; ENST00000402687; ENSP00000385704; ENSG00000137573.
DR   Ensembl; ENST00000419716; ENSP00000390315; ENSG00000137573.
DR   Ensembl; ENST00000458141; ENSP00000403040; ENSG00000137573.
DR   GeneID; 23213; -.
DR   KEGG; hsa:23213; -.
DR   UCSC; uc003xyd.2; human.
DR   CTD; 23213; -.
DR   GeneCards; GC08P065873; -.
DR   H-InvDB; HIX0007570; -.
DR   HGNC; HGNC:20391; SULF1.
DR   MIM; 610012; gene.
DR   neXtProt; NX_Q8IWU6; -.
DR   Orphanet; 2496; 8q13 microdeletion syndrome.
DR   PharmGKB; PA134861022; -.
DR   InParanoid; Q8IWU6; -.
DR   OMA; GATFINA; -.
DR   OrthoDB; EOG4VT5WH; -.
DR   PhylomeDB; Q8IWU6; -.
DR   NextBio; 44771; -.
DR   ArrayExpress; Q8IWU6; -.
DR   Bgee; Q8IWU6; -.
DR   CleanEx; HS_SULF1; -.
DR   Genevestigator; Q8IWU6; -.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR   GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR   GO; GO:0004065; F:arylsulfatase activity; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0060348; P:bone development; ISS:BHF-UCL.
DR   GO; GO:0030201; P:heparan sulfate proteoglycan metabolic process; NAS:UniProtKB.
DR   GO; GO:0001822; P:kidney development; ISS:BHF-UCL.
DR   GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; ISS:BHF-UCL.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core.
DR   InterPro; IPR014615; Extracellular_sulfatase.
DR   InterPro; IPR000917; Sulfatase.
DR   Gene3D; G3DSA:3.40.720.10; Alk_phosphtse; 3.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF036665; Sulf1; 1.
DR   SUPFAM; SSF53649; Alkaline_phosphatase_core; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; FALSE_NEG.
DR   HOGENOMDNA; HS8.PE1801; -.
KW   ENSG000001375731755old_1320000031; ENSP000004030407901old_1320000031;
KW   Q7Z2W2_HUMAN; Q96E28_HUMAN; AB029000; AF545571; AK074873; AY101175;
KW   BX571746;
KW   Apoptosis; Calcium; Complete proteome; Endoplasmic reticulum;
KW   Glycoprotein; Golgi apparatus; Hydrolase; Metal-binding;
KW   Reference proteome; Signal.
SQ   SEQUENCE   871 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKYSCCALVL AVLGTELLGS LCSTVRSPRF RGRIQQERKN IRPNIILVLT DDQDVELGSL
     QVMNKTRKIM EHGGATFINA FVTTPMCCPS RSSMLTGKYV HNHNVYTNNE NCSSPSWQAM
     HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLIKNSRFYN YTVCRNGIKE
     KHGFDYAKDY FTDLITNESI NYFKMSKRMY PHRPVMMVIS HAAPHGPEDS APQFSKLYPN
     ASQHITPSYN YAPNMDKHWI MQYTGPMLPI HMEFTNILQR KRLQTLMSVD DSVERLYNML
     VETGELENTY IIYTADHGYH IGQFGLVKGK SMPYDFDIRV PFFIRGPSVE PGSIVPQIVL
     NIDLAPTILD IAGLDTPPDV DGKSVLKLLD PEKPGNRFRT NKKAKIWRDT FLVERGKFLR
     KKEESSKNIQ QSNHLPKYER VKELCQQARY QTACEQPGQK WQCIEDTSGK LRIHKCKGPS
     DLLTVRQSTR NLYARGFHDK DKECSCRESG YRASRSQRKS QRQFLRNQGT PKYKPRFVHT
     RQTRSLSVEF EGEIYDINLE EEEELQVLQP RNIAKRHDEG HKGPRDLQAS SGGNRGRMLA
     DSSNAVGPPT TVRVTHKCFI LPNDSIHCER ELYQSARAWK DHKAYIDKEI EALQDKIKNL
     REVRGHLKRR KPEECSCSKQ SYYNKEKGVK KQEKLKSHLH PFKEAAQEVD SKLQLFKENN
     RRRKKERKEK RRQRKGEECS LPGLTCFTHD NNHWQTAPFW NLGSFCACTS SNNNTYWCLR
     TVNETHNFLF CEFATGFLEY FDMNTDPYQL TNTVHTVERG ILNQLHVQLM ELRSCQGYKQ
     CNPRPKNLDV GNKDGGSYDL HRGQLWDGWE G
//

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