(data stored in ACNUC3292 zone)

HOGENOM: HS8_PE2557

ID   HS8_PE2557                           STANDARD;      PRT;   926 AA.
AC   HS8_PE2557; Q07617; A6NP70; Q7Z5G1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Sperm-associated antigen 1;AltName: Full=HSD-3 8;AltName:
DE   Full=Infertility-related sperm protein Spag-1; (HS8.PE2557).
GN   Name=SPAG1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS8.PE2557.
CC       Homo sapiens chromosome 8 GRCh37  sequence 1..146304022 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SPAG1_HUMAN
CC   -!- FUNCTION: Plays a role in fertilization. Binds GTP and has GTPase
CC       activity.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Detected in sperm and testis, in particular in
CC       pachytene primary spermatocytes.
CC   -!- MISCELLANEOUS: Antibodies against SPAG1 interfere with
CC       fertilization (By similarity).
CC   -!- SIMILARITY: Contains 9 TPR repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH55091.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
CC   -!- GENE_FAMILY: HOG000293399 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000104450;ENST00000388798;ENSP00000373450.
DR   EMBL; AC025647; - ;
DR   EMBL; AF311312; - ;
DR   EMBL; BC055091; - ;
DR   UniProtKB/Swiss-Prot; Q07617; A6NP70; Q7Z5G1; -.
DR   EMBL; AF311312; AAG23967.1; -; mRNA.
DR   EMBL; AC025647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC055091; AAH55091.1; ALT_SEQ; mRNA.
DR   IPI; IPI00292326; -.
DR   RefSeq; NP_003105.2; NM_003114.4.
DR   RefSeq; NP_757367.1; NM_172218.2.
DR   UniGene; Hs.591866; -.
DR   ProteinModelPortal; Q07617; -.
DR   SMR; Q07617; 208-326, 445-554, 622-727.
DR   STRING; Q07617; -.
DR   PhosphoSite; Q07617; -.
DR   PRIDE; Q07617; -.
DR   Ensembl; ENST00000251809; ENSP00000251809; ENSG00000104450.
DR   Ensembl; ENST00000388798; ENSP00000373450; ENSG00000104450.
DR   GeneID; 6674; -.
DR   KEGG; hsa:6674; -.
DR   CTD; 6674; -.
DR   GeneCards; GC08P096373; -.
DR   H-InvDB; HIX0201290; -.
DR   HGNC; HGNC:11212; SPAG1.
DR   MIM; 603395; gene.
DR   neXtProt; NX_Q07617; -.
DR   PharmGKB; PA36049; -.
DR   eggNOG; prNOG12778; -.
DR   GeneTree; ENSGT00600000084276; -.
DR   InParanoid; Q07617; -.
DR   OMA; EDYKEKT; -.
DR   OrthoDB; EOG4FFD17; -.
DR   NextBio; 26021; -.
DR   ArrayExpress; Q07617; -.
DR   Bgee; Q07617; -.
DR   CleanEx; HS_SPAG1; -.
DR   Genevestigator; Q07617; -.
DR   GermOnline; ENSG00000104450; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; TAS:ProtInc.
DR   InterPro; IPR023114; Elongated_TPR_rpt_dom.
DR   InterPro; IPR001440; TPR-1.
DR   InterPro; IPR013026; TPR-contain.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   Gene3D; G3DSA:1.10.150.160; Elongated_TPR_rpt_dom; 1.
DR   Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 3.
DR   Pfam; PF00515; TPR_1; 4.
DR   SMART; SM00028; TPR; 9.
DR   PROSITE; PS50005; TPR; 8.
DR   PROSITE; PS50293; TPR_REGION; 4.
DR   HOGENOMDNA; HS8.PE2557; -.
KW   ENSG000001044501755old_1320000031; ENSP000003734507901old_1320000031;
KW   AC025647; AF311312; BC055091;
KW   Complete proteome; Cytoplasm; Fertilization; GTP-binding; Hydrolase;
KW   Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome;
KW   Repeat; TPR repeat.
SQ   SEQUENCE   926 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTTKDYPSLW GFGTTKTFKI PIEHLDFKYI EKCSDVKHLE KILCVLRSGE EGYYPELTEF
     CEKHLQALAP ESRALRKDKP AATAASFTAE EWEKIDGDIK SWVSEIKKEE DKMHFHETET
     FPAMKDNLPP VRGSNSCLHV GKEKYSKRPT KKKTPRDYAE WDKFDVEKEC LKIDEDYKEK
     TVIDKSHLSK IETRIDTAGL TEKEKDFLAT REKEKGNEAF NSGDYEEAVM YYTRSISALP
     TVVAYNNRAQ AEIKLQNWNS AFQDCEKVLE LEPGNVKALL RRATTYKHQN KLREATEDLS
     KVLDVEPDND LAKKTLSEVE RDLKNSEAAS ETQTKGKRMV IQEIENSEDE EGKSGRKHED
     GGGDKKPAEP AGAARAAQPC VMGNIQKKLT GKAEGGKRPA RGAPQRGQTP EAGADKRSPR
     RASAAAAAGG GATGHPGGGQ GAENPAGLKS QGNELFRSGQ FAEAAGKYSA AIALLEPAGS
     EIADDLSILY SNRAACYLKE GNCSGCIQDC NRALELHPFS MKPLLRRAMA YETLEQYGKA
     YVDYKTVLQI DCGLQLANDS VNRLSRILME LDGPNWREKL SPIPAVPASV PLQAWHPAKE
     MISKQAGDSS SHRQQGITDE KTFKALKEEG NQCVNDKNYK DALSKYSECL KINNKECAIY
     TNRALCYLKL CQFEEAKQDC DQALQLADGN VKAFYRRALA HKGLKNYQKS LIDLNKVILL
     DPSIIEAKME LEEVTRLLNL KDKTAPFNKE KERRKIEIQE VNEGKEEPGR PAGEVSMGCL
     ASEKGGKSSR SPEDPEKLPI AKPNNAYEFG QIINALSTRK DKEACAHLLA ITAPKDLPMF
     LSNKLEGDTF LLLIQSLKNN LIEKDPSLVY QHLLYLSKAE RFKMMLTLIS KGQKELIEQL
     FEDLSDTPNN HFTLEDIQAL KRQYEL
//

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