(data stored in ACNUC27125 zone)

HOGENOM: HS8_PE555

ID   HS8_PE555                            STANDARD;      PRT;   502 AA.
AC   HS8_PE555; P48454; Q9BSS6; Q9H4M5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit
DE   gamma isoform; EC=3.1.3 16;AltName: Full=CAM-PRP catalytic
DE   subunit;AltName: Full=Calcineurin, testis-specific catalytic
DE   subunit;AltName: Full=Calmodulin-dependent calcineurin A subunit gamma
DE   isoform; (HS8.PE555).
GN   Name=PPP3CC; Synonyms=CALNA3, CNA3;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS8.PE555.
CC       Homo sapiens chromosome 8 GRCh37  sequence 1..146304022 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:PP2BC_HUMAN
CC   -!- FUNCTION: Calcium-dependent, calmodulin-stimulated protein
CC       phosphatase. This subunit may have a role in the calmodulin
CC       activation of calcineurin.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Composed of two components (A and B), the A component is
CC       the catalytic subunit and the B component confers calcium
CC       sensitivity.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P48454-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P48454-2; Sequence=VSP_037946;
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-2B
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000172699 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000120910;ENST00000289963;ENSP00000289963.
DR   EMBL; AY007249; - ;
DR   EMBL; BC004864; - ;
DR   EMBL; CH471080; - ;
DR   EMBL; S40010; - ;
DR   EMBL; S40011; - ;
DR   EMBL; S46622; - ;
DR   UniProtKB/Swiss-Prot; P48454; Q9BSS6; Q9H4M5; -.
DR   EMBL; S46622; AAB23769.1; -; mRNA.
DR   EMBL; AY007249; AAG02563.1; -; mRNA.
DR   EMBL; CH471080; EAW63677.1; -; Genomic_DNA.
DR   EMBL; CH471080; EAW63679.1; -; Genomic_DNA.
DR   EMBL; BC004864; AAH04864.1; -; mRNA.
DR   IPI; IPI00305491; -.
DR   IPI; IPI00413731; -.
DR   PIR; JC1283; JC1283.
DR   RefSeq; NP_005596.2; NM_005605.3.
DR   UniGene; Hs.728861; -.
DR   ProteinModelPortal; P48454; -.
DR   SMR; P48454; 8-368.
DR   IntAct; P48454; 2.
DR   STRING; P48454; -.
DR   PhosphoSite; P48454; -.
DR   PRIDE; P48454; -.
DR   Ensembl; ENST00000289963; ENSP00000289963; ENSG00000120910.
DR   GeneID; 5533; -.
DR   KEGG; hsa:5533; -.
DR   CTD; 5533; -.
DR   GeneCards; GC08P020840; -.
DR   H-InvDB; HIX0201288; -.
DR   HGNC; HGNC:9316; PPP3CC.
DR   HPA; CAB024950; -.
DR   HPA; HPA023396; -.
DR   MIM; 114107; gene.
DR   neXtProt; NX_P48454; -.
DR   PharmGKB; PA33680; -.
DR   eggNOG; prNOG11167; -.
DR   OrthoDB; EOG437RDR; -.
DR   PhylomeDB; P48454; -.
DR   Pathway_Interaction_DB; bcr_5pathway; BCR signaling pathway.
DR   Reactome; REACT_15295; Opioid Signalling.
DR   Reactome; REACT_578; Apoptosis.
DR   ArrayExpress; P48454; -.
DR   Bgee; P48454; -.
DR   CleanEx; HS_PPP3CC; -.
DR   Genevestigator; P48454; -.
DR   GermOnline; ENSG00000120910; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008633; P:activation of pro-apoptotic gene products; EXP:Reactome.
DR   GO; GO:0008629; P:induction of apoptosis by intracellular signals; TAS:Reactome.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR   HOGENOMDNA; HS8.PE555; -.
KW   ENSG000001209101755old_1320000031; ENSP000002899637901old_1320000031;
KW   Q16475_HUMAN; Q16476_HUMAN; AY007249; BC004864; CH471080; S40010; S40011;
KW   S46622;
KW   Alternative splicing; Calmodulin-binding; Complete proteome;
KW   Hydrolase; Iron; Metal-binding; Polymorphism; Protein phosphatase;
KW   Reference proteome; Zinc.
SQ   SEQUENCE   502 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG RLEEEVALKI
     INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY
     FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTDYFTFKQ ECRIKYSEQV YDACMETFDC
     LPLAALLNQQ FLCVHGGMSP EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT
     LEHYTHNTVR GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT
     IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM
     LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM ARVFSILRQE SESVLTLKGL
     TPTGTLPLGV LSGGKQTIET AIRGFSLQHK IRSFEEARGL DRINERMPPR KDSIHAGGPM
     KSVTSAHSHA AHRSDQGKKA HS
//

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