(data stored in ACNUC30567 zone)

HOGENOM: HS8_PE691

ID   HS8_PE691                            STANDARD;      PRT;   470 AA.
AC   HS8_PE691; O15204;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ADAM DEC1; EC=3.4.24 -;AltName: Full=A disintegrin and
DE   metalloproteinase domain-like protein decysin-1; Short=ADAM-like protein
DE   decysin-1;Flags: Precursor; (HS8.PE691).
GN   Name=ADAMDEC1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS8.PE691.
CC       Homo sapiens chromosome 8 GRCh37  sequence 1..146304022 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADEC1_HUMAN
CC   -!- FUNCTION: May play an important role in the control of the immune
CC       response and during pregnancy (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed highly in the small intestine and
CC       appendix, moderately in lymph node, mucosal lining of the colon,
CC       thymus, spleen and very weakly in the bone marrow. Predominantly
CC       expressed in dendritic cells (DC) of the germinal center. Weakly
CC       expressed in monocyte and highly expressed in macrophage. Absent
CC       in immature DC.
CC   -!- INDUCTION: Induced during DC maturation and up-regulated in
CC       response to T-cell signals. In macrophage up-regulated by
CC       bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-
CC       dihydroxyvitamin D3 during differentiation of primary monocyte
CC       into macrophage.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000134028;ENST00000256412;ENSP00000256412.
DR   EMBL; AK300959; - ;
DR   EMBL; AK301007; - ;
DR   EMBL; AK316320; - ;
DR   EMBL; AK316322; - ;
DR   EMBL; BC069582; - ;
DR   EMBL; BC074877; - ;
DR   EMBL; BC074878; - ;
DR   EMBL; Y13323; - ;
DR   UniProtKB/Swiss-Prot; O15204; -.
DR   EMBL; Y13323; CAA73764.2; -; mRNA.
DR   EMBL; BC069582; AAH69582.1; -; mRNA.
DR   EMBL; BC074877; AAH74877.1; -; mRNA.
DR   EMBL; BC074878; AAH74878.1; -; mRNA.
DR   IPI; IPI00004480; -.
DR   RefSeq; NP_001138744.1; NM_001145272.1.
DR   RefSeq; NP_055294.1; NM_014479.3.
DR   UniGene; Hs.521459; -.
DR   ProteinModelPortal; O15204; -.
DR   SMR; O15204; 207-470.
DR   IntAct; O15204; 1.
DR   STRING; O15204; -.
DR   MEROPS; M12.219; -.
DR   PhosphoSite; O15204; -.
DR   PeptideAtlas; O15204; -.
DR   PRIDE; O15204; -.
DR   Ensembl; ENST00000256412; ENSP00000256412; ENSG00000134028.
DR   GeneID; 27299; -.
DR   KEGG; hsa:27299; -.
DR   UCSC; uc003xdz.1; human.
DR   CTD; 27299; -.
DR   GeneCards; GC08P022786; -.
DR   H-InvDB; HIX0034353; -.
DR   HGNC; HGNC:16299; ADAMDEC1.
DR   HPA; HPA028317; -.
DR   MIM; 606393; gene.
DR   neXtProt; NX_O15204; -.
DR   eggNOG; prNOG17082; -.
DR   GeneTree; ENSGT00570000079242; -.
DR   InParanoid; O15204; -.
DR   OMA; LRGYFTH; -.
DR   OrthoDB; EOG4F1X36; -.
DR   PhylomeDB; O15204; -.
DR   NextBio; 50277; -.
DR   ArrayExpress; O15204; -.
DR   Bgee; O15204; -.
DR   CleanEx; HS_ADAMDEC1; -.
DR   Genevestigator; O15204; -.
DR   GermOnline; ENSG00000134028; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; NAS:UniProtKB.
DR   GO; GO:0005178; F:integrin binding; NAS:UniProtKB.
DR   GO; GO:0004222; F:metalloendopeptidase activity; NAS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.
DR   GO; GO:0007162; P:negative regulation of cell adhesion; NAS:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00050; DISIN; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00546; CYSTEINE_SWITCH; FALSE_NEG.
DR   PROSITE; PS00427; DISINTEGRIN_1; FALSE_NEG.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
DR   HOGENOMDNA; HS8.PE691; -.
KW   ENSG000001340281755old_1320000031; ENSP000002564127901old_1320000031;
KW   B7Z6U5_HUMAN; B7Z6V5_HUMAN; B7ZAK5_HUMAN; AK300959; AK301007; AK316320;
KW   BC069582; BC074877; BC074878; Y13323;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase;
KW   Metal-binding; Metalloprotease; Polymorphism; Protease;
KW   Reference proteome; Secreted; Signal; Zinc; Zymogen.
SQ   SEQUENCE   470 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL HILHKREIKN
     NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP DYTETLYSPR GEEITTKPEN
     MEHCYYKGNI LNEKNSVASI STCDGLRGYF THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ
     DPANHTCGVK STDGKQGPIR ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL
     IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK
     KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM SHELGHVLGM
     PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT
     PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL TCKLKPGTDC GGDAPNHTTE
//

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