(data stored in ACNUC18858 zone)

HOGENOM: HS9_PE1019

ID   HS9_PE1019                           STANDARD;      PRT;   428 AA.
AC   HS9_PE1019; Q02742; Q6DJZ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein
DE   beta-1,6-N-acetylglucosaminyltransferase; EC=2.4.1 102;AltName: Full=Core
DE   2-branching enzyme;AltName: Full=Core2-GlcNAc-transferase; Short=C2GNT;
DE   Short=Core 2 GNT; (HS9.PE1019).
GN   Name=GCNT1; Synonyms=NACGT2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS9.PE1019.
CC       Homo sapiens chromosome 9 GRCh37  sequence 1..141153431 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GCNT1_HUMAN
CC   -!- FUNCTION: Forms critical branches in O-glycans.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-
CC       galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-
CC       galactosaminyl-R.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type
CC       II membrane protein.
CC   -!- TISSUE SPECIFICITY: Highly expressed in activated T-lymphocytes
CC       and myeloid cells.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC   -!- WEB RESOURCE: Name=GGDB; Note=GlycoGene database;
CC       URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GCNT1";
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - GTase;
CC       Note=Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-
CC       acetylglucosaminyltransferase;
CC       URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_541";
CC   -!- GENE_FAMILY: HOG000293251 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000187210;ENST00000376730;ENSP00000365920.
DR   EMBL; AK313343; - ;
DR   EMBL; AL161626; - ;
DR   EMBL; AL832647; - ;
DR   EMBL; BC074885; - ;
DR   EMBL; BC074886; - ;
DR   EMBL; BC109101; - ;
DR   EMBL; BC109102; - ;
DR   EMBL; CH471089; - ;
DR   EMBL; L41415; - ;
DR   EMBL; M97347; - ;
DR   UniProtKB/Swiss-Prot; Q02742; Q6DJZ4; -.
DR   EMBL; M97347; AAA35919.1; -; mRNA.
DR   EMBL; L41415; AAA96661.1; -; Genomic_DNA.
DR   EMBL; AL161626; CAI39746.1; -; Genomic_DNA.
DR   EMBL; CH471089; EAW62580.1; -; Genomic_DNA.
DR   EMBL; BC074885; AAH74885.1; -; mRNA.
DR   EMBL; BC074886; AAH74886.1; -; mRNA.
DR   EMBL; BC109101; AAI09102.1; -; mRNA.
DR   EMBL; BC109102; AAI09103.1; -; mRNA.
DR   IPI; IPI00295368; -.
DR   PIR; A46293; A46293.
DR   RefSeq; NP_001091102.1; NM_001097633.1.
DR   RefSeq; NP_001091103.1; NM_001097634.1.
DR   RefSeq; NP_001091104.1; NM_001097635.1.
DR   RefSeq; NP_001091105.1; NM_001097636.1.
DR   RefSeq; NP_001481.2; NM_001490.4.
DR   UniGene; Hs.521568; -.
DR   ProteinModelPortal; Q02742; -.
DR   SMR; Q02742; 56-424.
DR   STRING; Q02742; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PhosphoSite; Q02742; -.
DR   PRIDE; Q02742; -.
DR   Ensembl; ENST00000376730; ENSP00000365920; ENSG00000187210.
DR   Ensembl; ENST00000442371; ENSP00000415454; ENSG00000187210.
DR   Ensembl; ENST00000444201; ENSP00000390703; ENSG00000187210.
DR   GeneID; 2650; -.
DR   KEGG; hsa:2650; -.
DR   CTD; 2650; -.
DR   GeneCards; GC09P048885; -.
DR   H-InvDB; HIX0008111; -.
DR   HGNC; HGNC:4203; GCNT1.
DR   HPA; HPA031151; -.
DR   MIM; 600391; gene.
DR   neXtProt; NX_Q02742; -.
DR   PharmGKB; PA168; -.
DR   eggNOG; prNOG04535; -.
DR   InParanoid; Q02742; -.
DR   OMA; FSGSAYF; -.
DR   OrthoDB; EOG4W0XDC; -.
DR   PhylomeDB; Q02742; -.
DR   ArrayExpress; Q02742; -.
DR   Bgee; Q02742; -.
DR   CleanEx; HS_GCNT1; -.
DR   Genevestigator; Q02742; -.
DR   GermOnline; ENSG00000187210; Homo sapiens.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; TAS:ProtInc.
DR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; TADR   GO; GO:0006493; P:protein O-linked glycosylation; TAS:ProtInc.
DR   GO; GO:0006493; P:protein O-linked glycosylation; TAS:ProtInc.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
DR   HOGENOMDNA; HS9.PE1019; -.
KW   ENSG000001872101755old_1320000031; ENSP000003659207901old_1320000031;
KW   B2R8E9_HUMAN; Q86T81_HUMAN; AK313343; AL161626; AL832647; BC074885;
KW   BC109101; BC109102; CH471089; L41415; M97347;
KW   Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase;
KW   Golgi apparatus; Membrane; Phosphoprotein; Polymorphism;
KW   Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   428 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLRTLLRRRL FSYPTKYYFM VLVLSLITFS VLRIHQKPEF VSVRHLELAG ENPSSDINCT
     KVLQGDVNEI QKVKLEILTV KFKKRPRWTP DDYINMTSDC SSFIKRRKYI VEPLSKEEAE
     FPIAYSIVVH HKIEMLDRLL RAIYMPQNFY CIHVDTKSED SYLAAVMGIA SCFSNVFVAS
     RLESVVYASW SRVQADLNCM KDLYAMSANW KYLINLCGMD FPIKTNLEIV RKLKLLMGEN
     NLETERMPSH KEERWKKRYE VVNGKLTNTG TVKMLPPLET PLFSGSAYFV VSREYVGYVL
     QNEKIQKLME WAQDTYSPDE YLWATIQRIP EVPGSLPASH KYDLSDMQAV ARFVKWQYFE
     GDVSKGAPYP PCDGVHVRSV CIFGAGDLNW MLRKHHLFAN KFDVDVDLFA IQCLDEHLRH
     KALETLKH
//

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