(data stored in ACNUC21429 zone)

HOGENOM: HS9_PE1103

ID   HS9_PE1103                           STANDARD;      PRT;   589 AA.
AC   HS9_PE1103;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquilin-1;AltName: Full=Protein linking IAP with
DE   cytoskeleton 1; Short=PLIC-1; Short=hPLIC-1; (HS9.PE1103).
GN   Name=UBQLN1; Synonyms=DA41, PLIC1;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HS9.PE1103.
CC       Homo sapiens chromosome 9 GRCh37  sequence 1..141153431 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:UBQL1_HUMAN
CC   -!- FUNCTION: Links CD47 to the cytoskeleton. Promotes the surface
CC       expression of GABA-A receptors (By similarity). Promotes the
CC       accumulation of uncleaved PSEN1 and PSEN2 by stimulating their
CC       biosynthesis. Has no effect on PSEN1 and PSEN2 degradation.
CC   -!- SUBUNIT: Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1,
CC       GABRB2 and GABRB3 (By similarity). Binds UBE3A, BTRC, P4HB, MTOR,
CC       PSEN1 and PSEN2. Interacts with the proteasome 19S subunit.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UMX0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UMX0-2; Sequence=VSP_009787;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Highly expressed throughout the
CC       brain; detected in neurons and in neuropathological lesions, such
CC       as neurofibrillary tangles and Lewy bodies. Highly expressed in
CC       heart, placenta, pancreas, lung, liver, skeletal muscle and
CC       kidney.
CC   -!- DOMAIN: Binds PSEN1 and PSEN2 via its UBA domain.
CC   -!- PTM: Phosphorylated.
CC   -!- SIMILARITY: Contains 1 UBA domain.
CC   -!- SIMILARITY: Contains 1 ubiquitin-like domain.
CC   -!- GENE_FAMILY: HOG000234878 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000135018;ENST00000376395;ENSP00000365576.
DR   EMBL; AB035275; - ;
DR   EMBL; AB209468; - ;
DR   EMBL; AF176069; - ;
DR   EMBL; AF293384; - ;
DR   EMBL; AK027556; - ;
DR   EMBL; AK027576; - ;
DR   EMBL; AK074535; - ;
DR   EMBL; AL136643; - ;
DR   EMBL; AL354920; - ;
DR   EMBL; BC010066; - ;
DR   EMBL; BC039294; - ;
DR   EMBL; CH471089; - ;
DR   UniProtKB/Swiss-Prot; Q9UMX0; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; -.
DR   EMBL; AF176069; AAD49751.3; -; mRNA.
DR   EMBL; AF293384; AAG02473.1; -; mRNA.
DR   EMBL; AB035275; BAB20436.1; -; mRNA.
DR   EMBL; AL136643; CAB66578.1; -; mRNA.
DR   EMBL; AL354920; CAI15100.1; -; Genomic_DNA.
DR   EMBL; AL354920; CAI15101.1; -; Genomic_DNA.
DR   EMBL; CH471089; EAW62659.1; -; Genomic_DNA.
DR   EMBL; CH471089; EAW62661.1; -; Genomic_DNA.
DR   EMBL; BC010066; AAH10066.1; -; mRNA.
DR   EMBL; BC039294; AAH39294.1; -; mRNA.
DR   EMBL; AK074535; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00071180; -.
DR   IPI; IPI00099550; -.
DR   RefSeq; NP_038466.2; NM_013438.4.
DR   RefSeq; NP_444295.1; NM_053067.2.
DR   UniGene; Hs.9589; -.
DR   PDB; 2JY5; NMR; -; A=541-586.
DR   PDB; 2JY6; NMR; -; B=541-586.
DR   PDB; 2KLC; NMR; -; A=34-112.
DR   PDBsum; 2JY5; -.
DR   PDBsum; 2JY6; -.
DR   PDBsum; 2KLC; -.
DR   ProteinModelPortal; Q9UMX0; -.
DR   SMR; Q9UMX0; 1-112, 537-586.
DR   IntAct; Q9UMX0; 27.
DR   MINT; MINT-150317; -.
DR   STRING; Q9UMX0; -.
DR   PhosphoSite; Q9UMX0; -.
DR   REPRODUCTION-2DPAGE; IPI00071180; -.
DR   PRIDE; Q9UMX0; -.
DR   Ensembl; ENST00000376395; ENSP00000365576; ENSG00000135018.
DR   GeneID; 29979; -.
DR   KEGG; hsa:29979; -.
DR   UCSC; uc004amv.1; human.
DR   UCSC; uc004amw.1; human.
DR   CTD; 29979; -.
DR   GeneCards; GC09M056100; -.
DR   H-InvDB; HIX0008127; -.
DR   HGNC; HGNC:12508; UBQLN1.
DR   HPA; CAB037256; -.
DR   MIM; 605046; gene.
DR   neXtProt; NX_Q9UMX0; -.
DR   PharmGKB; PA37155; -.
DR   GeneTree; ENSGT00390000005720; -.
DR   InParanoid; Q9UMX0; -.
DR   OMA; NRSQDHS; -.
DR   OrthoDB; EOG48KRBD; -.
DR   PhylomeDB; Q9UMX0; -.
DR   NextBio; 52732; -.
DR   ArrayExpress; Q9UMX0; -.
DR   Bgee; Q9UMX0; -.
DR   CleanEx; HS_UBQLN1; -.
DR   Genevestigator; Q9UMX0; -.
DR   GermOnline; ENSG00000135018; Homo sapiens.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; NAS:UniProtKB.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR   GO; GO:0006915; P:apoptosis; IMP:HGNC.
DR   GO; GO:0031396; P:regulation of protein ubiquitination; IDA:HGNC.
DR   GO; GO:0001666; P:response to hypoxia; IMP:HGNC.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR009060; UBA-like.
DR   InterPro; IPR000449; UBA/transl_elong_EF1B_N.
DR   InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR   InterPro; IPR015496; Ubiquilin.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   PANTHER; PTHR10677; Ubiquilin; 1.
DR   Pfam; PF00627; UBA; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00727; STI1; 4.
DR   SMART; SM00165; UBA; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   SUPFAM; SSF46934; UBA_like; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; FALSE_NEG.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   HOGENOMDNA; HS9.PE1103; -.
KW   ENSG000001350181755old_1320000031; ENSP000003655767901old_1320000031;
KW   B3KNI2_HUMAN; B3KNI8_HUMAN; Q59FJ2_HUMAN; AB035275; AB209468; AF176069;
KW   AK027556; AK027576; AK074535; AL136643; AL354920; BC010066; BC039294;
KW   CH471089;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein;
KW   Proteasome; Reference proteome.
SQ   SEQUENCE   589 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ
     FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT
     NTAGSNVTTS STPNSNSTSG SATSNPFGLG GLGGLAGLSS LGLNTTNFSE LQSQMQRQLL
     SNPEMMVQIM ENPFVQSMLS NPDLMRQLIM ANPQMQQLIQ RNPEISHMLN NPDIMRQTLE
     LARNPAMMQE MMRNQDRALS NLESIPGGYN ALRRMYTDIQ EPMLSAAQEQ FGGNPFASLV
     SNTSSGEGSQ PSRTENRDPL PNPWAPQTSQ SSSASSGTAS TVGGTTGSTA SGTSGQSTTA
     PNLVPGVGAS MFNTPGMQSL LQQITENPQL MQNMLSAPYM RSMMQSLSQN PDLAAQMMLN
     NPLFAGNPQL QEQMRQQLPT FLQQMQNPDT LSAMSNPRAM QALLQIQQGL QTLATEAPGL
     IPGFTPGLGA LGSTGGSSGT NGSNATPSEN TSPTAGTTEP GHQQFIQQML QALAGVNPQL
     QNPEVRFQQQ LEQLSAMGFL NREANLQALI ATGGDINAAI ERLLGSQPS
//

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