(data stored in ACNUC8465 zone)

HOGENOM: HSX_PE106

ID   HSX_PE106                            STANDARD;      PRT;   185 AA.
AC   HSX_PE106; Q08623; B2R7X6; B4DV93; Q53F84; Q96EB8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pseudouridine-5'-monophosphatase; Short=5'-PsiMPase;
DE   EC=3.1.3 n6;AltName: Full=Haloacid dehalogenase-like hydrolase
DE   domain-containing protein 1;AltName: Full=Haloacid dehalogenase-like
DE   hydrolase domain-containing protein 1A;AltName: Full=Protein GS1;
DE   (HSX.PE106).
GN   Name=HDHD1; Synonyms=DXF68S1E, FAM16AX, GS1, HDHD1A;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE106.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:HDHD1_HUMAN
CC   -!- FUNCTION: Dephosphorylates pseudouridine 5'-phosphate, a potential
CC       intermediate in rRNA degradation. Pseudouridine is then excreted
CC       intact in urine.
CC   -!- CATALYTIC ACTIVITY: pseudouridine 5'-monophosphate + H(2)O =
CC       Pseudouridine + phosphate.
CC   -!- COFACTOR: Magnesium.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=0.38 uM for 5'-PsiMP;
CC         KM=1.5 mM for 3'-AMP;
CC         KM=5.9 mM for Fructose-6-P;
CC         KM=9.4 mM for 5'-UMP;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q08623-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q08623-2; Sequence=VSP_040029;
CC         Note=No experimental confirmation available;
CC   -!- INDUCTION: Inhibited by low concentrations of calcium.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       CbbY/CbbZ/Gph/YieH family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA58622.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAH12494.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAD97125.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAG35973.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- GENE_FAMILY: HOG000248341 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000130021;ENST00000412827;ENSP00000406260.
DR   EMBL; AK300985; - ;
DR   EMBL; CH471074; - ;
DR   UniProtKB/Swiss-Prot; Q08623; B2R7X6; B4DV93; Q53F84; Q96EB8; -.
DR   EMBL; AK300985; BAG62605.1; -; mRNA.
DR   EMBL; AK313155; BAG35973.1; ALT_INIT; mRNA.
DR   EMBL; AK223405; BAD97125.1; ALT_INIT; mRNA.
DR   EMBL; AC073583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471074; EAW98748.1; -; Genomic_DNA.
DR   EMBL; BC012494; AAH12494.1; ALT_INIT; mRNA.
DR   EMBL; M86934; AAA58622.1; ALT_INIT; mRNA.
DR   IPI; IPI00302436; -.
DR   IPI; IPI00908643; -.
DR   RefSeq; NP_001129037.1; NM_001135565.1.
DR   RefSeq; NP_001171607.1; NM_001178136.1.
DR   RefSeq; NP_036212.3; NM_012080.4.
DR   UniGene; Hs.185910; -.
DR   PDB; 3L5K; X-ray; 2.00 A; A=1-228.
DR   PDBsum; 3L5K; -.
DR   ProteinModelPortal; Q08623; -.
DR   SMR; Q08623; 1-228.
DR   STRING; Q08623; -.
DR   PhosphoSite; Q08623; -.
DR   PRIDE; Q08623; -.
DR   Ensembl; ENST00000381077; ENSP00000370467; ENSG00000130021.
DR   Ensembl; ENST00000412827; ENSP00000406260; ENSG00000130021.
DR   GeneID; 8226; -.
DR   KEGG; hsa:8226; -.
DR   NMPDR; fig|9606.3.peg.32410; -.
DR   UCSC; uc004crv.1; human.
DR   CTD; 8226; -.
DR   GeneCards; GC0XM004825; -.
DR   H-InvDB; HIX0016639; -.
DR   HGNC; HGNC:16818; HDHD1.
DR   MIM; 306480; gene.
DR   neXtProt; NX_Q08623; -.
DR   PharmGKB; PA128394539; -.
DR   eggNOG; prNOG06037; -.
DR   GeneTree; ENSGT00390000014753; -.
DR   InParanoid; Q08623; -.
DR   OrthoDB; EOG46MBKM; -.
DR   PhylomeDB; Q08623; -.
DR   NextBio; 30966; -.
DR   ArrayExpress; Q08623; -.
DR   Bgee; Q08623; -.
DR   CleanEx; HS_HDHD1A; -.
DR   Genevestigator; Q08623; -.
DR   GermOnline; ENSG00000130021; Homo sapiens.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IEA:EC.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   InterPro; IPR023214; HAD-like_dom.
DR   InterPro; IPR006402; HAD-SF_hydro_IA_v3.
DR   Gene3D; G3DSA:3.40.50.1000; HAD-like_dom; 2.
DR   Pfam; PF00702; Hydrolase; 1.
DR   SUPFAM; SSF56784; HAD-like_dom; 1.
DR   TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
DR   HOGENOMDNA; HSX.PE106; -.
KW   ENSG000001300211755old_1320000031; ENSP000004062607901old_1320000031;
KW   AK300985; CH471074;
KW   3D-structure; Alternative splicing; Complete proteome; Hydrolase;
KW   Magnesium; Metal-binding; Nucleotide metabolism; Polymorphism;
KW   Reference proteome.
SQ   SEQUENCE   185 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAPPQPVTH LIFDMDGLLL DTERLYSVVF QEICNRYDKK YSWDVKSLVM GAEKLIIHLR
     KHGIPFALAT SSGSASFDMK TSRHKEFFSL FSHIVLGDDP EVQHGKPDPD IFLACAKRFS
     PPPAMEKCLV FEDAPNGVEA ALAAGMQVVM VPDGNLSRDL TTKATLVLNS LQDFQPELFG
     LPSYE
//

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