(data stored in ACNUC21429 zone)

HOGENOM: HSX_PE1228

ID   HSX_PE1228                           STANDARD;      PRT;   624 AA.
AC   HSX_PE1228; Q9UHD9; O94798; Q5D027; Q9H3W6; Q9HAZ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquilin-2;AltName: Full=Chap1;AltName: Full=DSK2
DE   homolog;AltName: Full=Protein linking IAP with cytoskeleton 2;
DE   Short=PLIC-2; Short=hPLIC-2;AltName: Full=Ubiquitin-like product
DE   Chap1/Dsk2; (HSX.PE1228).
GN   Name=UBQLN2; Synonyms=N4BP4, PLIC2; ORFNames=HRIHFB2157;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE1228.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:UBQL2_HUMAN
CC   -!- FUNCTION: Increases the half-life of proteins destined to be
CC       degraded by the proteasome; may modulate proteasome-mediated
CC       protein degradation.
CC   -!- SUBUNIT: Binds UBE3A and BTRC. Interacts with the 19S proteasome
CC       subunit.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Where it
CC       colocalizes with the proteasome. Associated with fibers in mitotic
CC       cells.
CC   -!- INDUCTION: Highly expressed in mitotic cells from metaphase to
CC       telophase. Expression in non-mitotic cells is very low.
CC   -!- SIMILARITY: Contains 1 UBA domain.
CC   -!- SIMILARITY: Contains 1 ubiquitin-like domain.
CC   -!- GENE_FAMILY: HOG000234878 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000188021;ENST00000338222;ENSP00000345195.
DR   EMBL; AB015344; - ;
DR   EMBL; AF189009; - ;
DR   EMBL; AF293385; - ;
DR   EMBL; AK297252; - ;
DR   EMBL; AL354793; - ;
DR   EMBL; AL442081; - ;
DR   EMBL; BC069237; - ;
DR   EMBL; CH471154; - ;
DR   UniProtKB/Swiss-Prot; Q9UHD9; O94798; Q5D027; Q9H3W6; Q9HAZ4; -.
DR   EMBL; AF189009; AAF17237.1; -; mRNA.
DR   EMBL; AF293385; AAG02474.1; -; mRNA.
DR   EMBL; AL354793; CAD13519.1; -; Genomic_DNA.
DR   EMBL; CH471154; EAW93233.1; -; Genomic_DNA.
DR   EMBL; BC069237; AAH69237.1; -; mRNA.
DR   EMBL; AL442081; CAC09446.1; -; mRNA.
DR   EMBL; AB015344; BAA34801.1; -; mRNA.
DR   IPI; IPI00409659; -.
DR   RefSeq; NP_038472.2; NM_013444.3.
DR   UniGene; Hs.179309; -.
DR   PDB; 1J8C; NMR; -; A=1-103.
DR   PDBsum; 1J8C; -.
DR   ProteinModelPortal; Q9UHD9; -.
DR   SMR; Q9UHD9; 1-103, 578-624.
DR   IntAct; Q9UHD9; 1.
DR   MINT; MINT-1192483; -.
DR   STRING; Q9UHD9; -.
DR   PhosphoSite; Q9UHD9; -.
DR   PeptideAtlas; Q9UHD9; -.
DR   PRIDE; Q9UHD9; -.
DR   Ensembl; ENST00000338222; ENSP00000345195; ENSG00000188021.
DR   GeneID; 29978; -.
DR   KEGG; hsa:29978; -.
DR   UCSC; uc004dus.1; human.
DR   CTD; 29978; -.
DR   GeneCards; GC0XP053642; -.
DR   H-InvDB; HIX0016830; -.
DR   HGNC; HGNC:12509; UBQLN2.
DR   HPA; CAB013481; -.
DR   HPA; HPA006431; -.
DR   MIM; 300264; gene.
DR   neXtProt; NX_Q9UHD9; -.
DR   PharmGKB; PA37156; -.
DR   eggNOG; prNOG07537; -.
DR   GeneTree; ENSGT00390000005720; -.
DR   InParanoid; Q9UHD9; -.
DR   OMA; SSPEMMI; -.
DR   OrthoDB; EOG48KRBD; -.
DR   PhylomeDB; Q9UHD9; -.
DR   NextBio; 52728; -.
DR   ArrayExpress; Q9UHD9; -.
DR   Bgee; Q9UHD9; -.
DR   CleanEx; HS_UBQLN2; -.
DR   Genevestigator; Q9UHD9; -.
DR   GermOnline; ENSG00000188021; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR009060; UBA-like.
DR   InterPro; IPR000449; UBA/transl_elong_EF1B_N.
DR   InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR   InterPro; IPR015496; Ubiquilin.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   PANTHER; PTHR10677; Ubiquilin; 1.
DR   Pfam; PF00627; UBA; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00727; STI1; 4.
DR   SMART; SM00165; UBA; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   SUPFAM; SSF46934; UBA_like; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; FALSE_NEG.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   HOGENOMDNA; HSX.PE1228; -.
KW   ENSG000001880211755old_1320000031; ENSP000003451957901old_1320000031;
KW   B4DM19_HUMAN; AB015344; AF189009; AF293385; AK297252; AL354793; AL442081;
KW   CH471154;
KW   3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus;
KW   Polymorphism; Reference proteome; Repeat.
SQ   SEQUENCE   624 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE NSSVQQFKEA
     ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL VIKSQNRPQG QSTQPSNAAG
     TNTTSASTPR SNSTPISTNS NPFGLGSLGG LAGLSSLGLS STNFSELQSQ MQQQLMASPE
     MMIQIMENPF VQSMLSNPDL MRQLIMANPQ MQQLIQRNPE ISHLLNNPDI MRQTLEIARN
     PAMMQEMMRN QDLALSNLES IPGGYNALRR MYTDIQEPML NAAQEQFGGN PFASVGSSSS
     SGEGTQPSRT ENRDPLPNPW APPPATQSSA TTSTTTSTGS GSGNSSSNAT GNTVAAANYV
     ASIFSTPGMQ SLLQQITENP QLIQNMLSAP YMRSMMQSLS QNPDLAAQMM LNSPLFTANP
     QLQEQMRPQL PAFLQQMQNP DTLSAMSNPR AMQALMQIQQ GLQTLATEAP GLIPSFTPGV
     GVGVLGTAIG PVGPVTPIGP IGPIVPFTPI GPIGPIGPTG PAAPPGSTGS GGPTGPTVSS
     AAPSETTSPT SESGPNQQFI QQMVQALAGA NAPQLPNPEV RFQQQLEQLN AMGFLNREAN
     LQALIATGGD INAAIERLLG SQPS
//

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