(data stored in ACNUC12215 zone)

HOGENOM: HSX_PE1666

ID   HSX_PE1666                           STANDARD;      PRT;   449 AA.
AC   HSX_PE1666; Q6PP77; B2RNN6; B4DKU2; Q5H9J6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=XK-related protein 2;AltName: Full=Membrane protein
DE   XPLAC;AltName: Full=X Kell blood group-related, X-linked; (HSX.PE1666).
GN   Name=XKRX; Synonyms=XKR2, XPLAC, XRG2;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE1666.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:XKR2_HUMAN
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6PP77-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6PP77-2; Sequence=VSP_037520;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the placenta, in
CC       syncytiotrophoblasts. Moderate levels in the adrenal gland, low
CC       levels in the trachea and very low levels in the bone marrow.
CC   -!- SIMILARITY: Belongs to the XK family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI37011.1; Type=Erroneous initiation;
CC       Sequence=AAI37012.1; Type=Erroneous initiation;
CC       Sequence=AAT00456.1; Type=Erroneous initiation;
CC       Sequence=AAT07088.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000118070 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000182489;ENST00000372956;ENSP00000362047.
DR   EMBL; AK296711; - ;
DR   EMBL; AY534239; - ;
DR   EMBL; AY589511; - ;
DR   EMBL; BC137010; - ;
DR   EMBL; BC137011; - ;
DR   EMBL; Z73417; - ;
DR   UniProtKB/Swiss-Prot; Q6PP77; B2RNN6; B4DKU2; Q5H9J6; -.
DR   EMBL; AY589511; AAT00456.1; ALT_INIT; mRNA.
DR   EMBL; AY534239; AAT07088.1; ALT_INIT; mRNA.
DR   EMBL; AK296711; BAG59304.1; -; mRNA.
DR   EMBL; Z73417; CAI41970.1; -; Genomic_DNA.
DR   EMBL; BC137010; AAI37011.1; ALT_INIT; mRNA.
DR   EMBL; BC137011; AAI37012.1; ALT_INIT; mRNA.
DR   IPI; IPI00401270; -.
DR   IPI; IPI00930497; -.
DR   RefSeq; NP_997724.2; NM_212559.2.
DR   UniGene; Hs.364911; -.
DR   UniGene; Hs.726481; -.
DR   ProteinModelPortal; Q6PP77; -.
DR   IntAct; Q6PP77; 1.
DR   STRING; Q6PP77; -.
DR   PRIDE; Q6PP77; -.
DR   Ensembl; ENST00000328526; ENSP00000327570; ENSG00000182489.
DR   Ensembl; ENST00000372956; ENSP00000362047; ENSG00000182489.
DR   GeneID; 402415; -.
DR   KEGG; hsa:402415; -.
DR   NMPDR; fig|9606.3.peg.33093; -.
DR   UCSC; uc004egn.1; human.
DR   CTD; 402415; -.
DR   GeneCards; GC0XM089966; -.
DR   H-InvDB; HIX0056207; -.
DR   HGNC; HGNC:29845; XKRX.
DR   HPA; HPA031886; -.
DR   MIM; 300684; gene.
DR   neXtProt; NX_Q6PP77; -.
DR   PharmGKB; PA134962569; -.
DR   eggNOG; prNOG15054; -.
DR   GeneTree; ENSGT00390000003231; -.
DR   InParanoid; Q6PP77; -.
DR   OrthoDB; EOG4RBQJK; -.
DR   PhylomeDB; Q6PP77; -.
DR   NextBio; 107493; -.
DR   ArrayExpress; Q6PP77; -.
DR   Bgee; Q6PP77; -.
DR   CleanEx; HS_XKRX; -.
DR   Genevestigator; Q6PP77; -.
DR   GermOnline; ENSG00000182489; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018629; Transport_prot_XK.
DR   Pfam; PF09815; XK-related; 1.
DR   HOGENOMDNA; HSX.PE1666; -.
KW   ENSG000001824891755old_1320000031; ENSP000003620477901old_1320000031;
KW   AK296711; AY534239; AY589511; BC137010; BC137011; Z73417;
KW   Alternative splicing; Cell membrane; Complete proteome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   449 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDRVYEIPEE PNVDPVSSLE EDVIRGANPR FTFPFSILFS TFLYCGEAAS ALYMVRIYRK
     NSETYWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDKPLSL FMHLILLGPV IRCLEAMIKY
     LTLWKKEEQE EPYVSLTRKK MLIDGEEVLI EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS
     VPQLTYQLYV SLISAEVPLG RVVLMVFSLV SVTYGATLCN MLAIQIKYDD YKIRLGPLEV
     LCITIWRTLE ITSRLLILVL FSATLKLKAV PFLVLNFLII LFEPWIKFWR SGAQMPNNIE
     KNFSRVGTLV VLISVTILYA GINFSCWSAL QLRLADRDLV DKGQNWGHMG LHYSVRLVEN
     VIMVLVFKFF GVKVLLNYCH SLIALQLIIA YLISIGFMLL FFQYLHPLRS LFTHNVVDYL
     HCVCCHQHPR TRVENSEPPF ETEARQSVV
//

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