(data stored in ACNUC8465 zone)

HOGENOM: HSX_PE2035

ID   HSX_PE2035                           STANDARD;      PRT;   165 AA.
AC   HSX_PE2035;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=UDP-N-acetylglucosamine transferase subunit ALG13 homolog;
DE   EC=2.4.1 141;AltName: Full=Asparagine-linked glycosylation 13
DE   homolog;AltName: Full=Glycosyltransferase 28 domain-containing protein 1;
DE   (HSX.PE2035).
GN   Name=ALG13; Synonyms=CXorf45; ORFNames=GLT28D1, MDS031;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE2035.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALG13_HUMAN
CC   -!- FUNCTION: Isoform 2 may be involved in protein N-glycosylation,
CC       second step of the dolichol-linked oligosaccharide pathway.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + N-acetyl-D-
CC       glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-
CC       diphosphodolichol.
CC   -!- SUBUNIT: Isoform 2 may interact with ALG14 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum (Probable).
CC       Note=Could be recruited to the cytosolic face of the endoplasmic
CC       reticulum membrane through its interaction with ALG14.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q9NP73-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NP73-2; Sequence=VSP_039301, VSP_039302;
CC       Name=3;
CC         IsoId=Q9NP73-3; Sequence=VSP_039299, VSP_039300;
CC         Note=No experimental confirmation available;
CC       Name=4;
CC         IsoId=Q9NP73-4; Sequence=VSP_039298, VSP_039303;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC   -!- SIMILARITY: Contains 1 OTU domain.
CC   -!- SIMILARITY: Contains 1 Tudor domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI17378.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAI17380.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAB15521.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAD96874.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAH14244.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAH14244.1; Type=Erroneous termination; Positions=424; Note=Translated as Cys;
CC       Sequence=CAI43016.2; Type=Erroneous gene model prediction;
CC       Sequence=CAM28219.1; Type=Erroneous gene model prediction;
CC   -!- WEB RESOURCE: Name=GGDB; Note=GlycoGene database;
CC       URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GLT28D1";
CC   -!- GENE_FAMILY: HOG000192807 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000101901;ENST00000371979;ENSP00000361047.
DR   EMBL; AF220051; - ;
DR   EMBL; AK026671; - ;
DR   EMBL; AK223154; - ;
DR   EMBL; AK300394; - ;
DR   EMBL; AK302729; - ;
DR   EMBL; AK304712; - ;
DR   EMBL; AK312229; - ;
DR   EMBL; AK316306; - ;
DR   EMBL; AK316522; - ;
DR   EMBL; AL049563; - ;
DR   EMBL; AL096764; - ;
DR   EMBL; BC005336; - ;
DR   EMBL; BC117377; - ;
DR   EMBL; BC117379; - ;
DR   EMBL; CH471120; - ;
DR   UniProtKB/Swiss-Prot; Q9NP73; B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; -.
DR   UniProtKB/Swiss-Prot; B7ZAJ1; B7ZB57; Q17RC3; Q5JXY9; Q9H5U8; -.
DR   EMBL; AF220051; AAF67644.1; -; mRNA.
DR   EMBL; AK026671; BAB15521.1; ALT_INIT; mRNA.
DR   EMBL; AK300394; BAH13276.1; -; mRNA.
DR   EMBL; AK302729; BAH13790.1; -; mRNA.
DR   EMBL; AK302890; BAH13833.1; -; mRNA.
DR   EMBL; AK304712; BAH14244.1; ALT_SEQ; mRNA.
DR   EMBL; AK316306; BAH14677.1; -; mRNA.
DR   EMBL; AK316522; BAH14893.1; -; mRNA.
DR   EMBL; AK312229; BAG35162.1; -; mRNA.
DR   EMBL; AL096764; CAB89277.1; -; Genomic_DNA.
DR   EMBL; AL049563; CAI43016.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL096764; CAM28218.1; -; Genomic_DNA.
DR   EMBL; AL049563; CAM28218.1; JOINED; Genomic_DNA.
DR   EMBL; AL096764; CAM28219.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL049563; CAM28219.1; JOINED; Genomic_DNA.
DR   EMBL; AL049563; CAM28289.1; -; Genomic_DNA.
DR   EMBL; AL096764; CAM28289.1; JOINED; Genomic_DNA.
DR   EMBL; CH471120; EAX02635.1; -; Genomic_DNA.
DR   EMBL; BC005336; AAH05336.1; -; mRNA.
DR   EMBL; BC117377; AAI17378.1; ALT_INIT; mRNA.
DR   EMBL; BC117379; AAI17380.1; ALT_INIT; mRNA.
DR   EMBL; AK223154; BAD96874.1; ALT_INIT; mRNA.
DR   IPI; IPI00020512; -.
DR   IPI; IPI00795917; -.
DR   IPI; IPI00963893; -.
DR   IPI; IPI00967654; -.
DR   RefSeq; NP_001034299.3; NM_001039210.3.
DR   RefSeq; NP_001161857.1; NM_001168385.1.
DR   RefSeq; NP_060936.1; NM_018466.4.
DR   UniGene; Hs.443061; -.
DR   ProteinModelPortal; Q9NP73; -.
DR   SMR; Q9NP73; 2-127, 219-350, 492-547.
DR   IntAct; Q9NP73; 3.
DR   MINT; MINT-3071434; -.
DR   STRING; Q9NP73; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PeptideAtlas; Q9NP73; -.
DR   PRIDE; Q9NP73; -.
DR   Ensembl; ENST00000251943; ENSP00000251943; ENSG00000101901.
DR   Ensembl; ENST00000371979; ENSP00000361047; ENSG00000101901.
DR   Ensembl; ENST00000394780; ENSP00000378260; ENSG00000101901.
DR   Ensembl; ENST00000436609; ENSP00000392990; ENSG00000101901.
DR   GeneID; 79868; -.
DR   KEGG; hsa:79868; -.
DR   UCSC; uc004epi.1; human.
DR   CTD; 79868; -.
DR   GeneCards; GC0XP100545; -.
DR   H-InvDB; HIX0016997; -.
DR   HGNC; HGNC:30881; ALG13.
DR   HPA; HPA002853; -.
DR   MIM; 300776; gene.
DR   neXtProt; NX_Q9NP73; -.
DR   PharmGKB; PA162376235; -.
DR   GeneTree; ENSGT00530000063508; -.
DR   OMA; STLKCFP; -.
DR   OrthoDB; EOG44J2H7; -.
DR   PhylomeDB; Q9NP73; -.
DR   Reactome; REACT_17015; Metabolism of proteins.
DR   NextBio; 69622; -.
DR   ArrayExpress; Q9NP73; -.
DR   Bgee; Q9NP73; -.
DR   CleanEx; HS_ALG13; -.
DR   Genevestigator; Q9NP73; -.
DR   GermOnline; ENSG00000072319; Homo sapiens.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; EXP:Reactome.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004577; F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; EXP:Reactome.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; EXP:Reactome.
DR   GO; GO:0030259; P:lipid glycosylation; IEA:InterPro.
DR   GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
DR   GO; GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
DR   InterPro; IPR007235; Glyco_trans_28_C.
DR   InterPro; IPR003323; OTU.
DR   InterPro; IPR018351; Tudor_subgr.
DR   Pfam; PF04101; Glyco_tran_28_C; 1.
DR   Pfam; PF02338; OTU; 1.
DR   PROSITE; PS50802; OTU; 1.
DR   PROSITE; PS50304; TUDOR; 1.
DR   HOGENOMDNA; HSX.PE2035; -.
KW   ENSG000001019011755old_1320000031; ENSP000003610477901old_1320000031;
KW   AF220051; AK026671; AK223154; AK300394; AK302729; AK304712; AK312229;
KW   AK316522; AL049563; AL096764; BC005336; BC117377; BC117379; CH471120;
KW   Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW   Glycosyltransferase; Reference proteome; Transferase.
SQ   SEQUENCE   165 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKCVFVTVGT TSFDDLIACV SAPDSLQKIE SLGYNRLILQ IGRGTVVPEP FSTESFTLDV
     YRYKDSLKED IQKADLVISH AGAGSCLETL EKGKPLVVVI NEKLMNNHQL ELAKQLHKEG
     HLFYCTCSTL PGLLQSMDLS TLKCYPPGQP EKFSAFLDKV VGLQK
//

If you have problems or comments...

PBIL Back to PBIL home page