(data stored in ACNUC26462 zone)

HOGENOM: HSX_PE2782

ID   HSX_PE2782                           STANDARD;      PRT;   343 AA.
AC   HSX_PE2782; Q6P2M8; B4DJR8; B7WPG0; D3DWU7; Q8N4R0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase type 1B;
DE   EC=2.7.11 17;AltName: Full=CaM kinase I beta; Short=CaM kinase IB;
DE   Short=CaM-KI beta; Short=CaMKI-beta;AltName: Full=Pregnancy up-regulated
DE   non-ubiquitously-expressed CaM kinase; (HSX.PE2782).
GN   Name=PNCK;
OS   HOMO SAPIENS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Homo.
OX   NCBI_TaxID=9606;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS HSX.PE2782.
CC       Homo sapiens chromosome X GRCh37  sequence 1..155260560 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCC1B_HUMAN
CC   -!- FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to
CC       a proposed calcium-triggered signaling cascade. In vitro
CC       phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and
CC       activates CAMK1 (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by Ca(2+)/calmodulin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q6P2M8-1; Sequence=Displayed;
CC         Note=Gene prediction based on similarity to mouse ortholog;
CC       Name=2;
CC         IsoId=Q6P2M8-2; Sequence=VSP_012635;
CC       Name=3;
CC         IsoId=Q6P2M8-3; Sequence=VSP_012634;
CC       Name=4;
CC         IsoId=Q6P2M8-5; Sequence=VSP_039091;
CC   -!- PTM: Phosphorylated by CAMKK1 (Probable).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family. CaMK subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000233016 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Homo_sapiens;ENSG00000130822;ENST00000340888;ENSP00000340586.
DR   EMBL; AK296203; - ;
DR   EMBL; BC064422; - ;
DR   EMBL; CH471172; - ;
DR   EMBL; CR611192; - ;
DR   EMBL; U52111; - ;
DR   UniProtKB/Swiss-Prot; Q6P2M8; B4DJR8; B7WPG0; D3DWU7; Q8N4R0; -.
DR   EMBL; AK296203; BAG58930.1; -; mRNA.
DR   EMBL; CR611192; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; U52111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471172; EAW72838.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72839.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72841.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72842.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72843.1; -; Genomic_DNA.
DR   EMBL; CH471172; EAW72845.1; -; Genomic_DNA.
DR   EMBL; BC064422; AAH64422.1; -; mRNA.
DR   IPI; IPI00413306; -.
DR   IPI; IPI00550276; -.
DR   IPI; IPI00639968; -.
DR   IPI; IPI00913860; -.
DR   RefSeq; NP_001034671.3; NM_001039582.3.
DR   UniGene; Hs.436667; -.
DR   ProteinModelPortal; Q6P2M8; -.
DR   SMR; Q6P2M8; 5-304.
DR   STRING; Q6P2M8; -.
DR   PhosphoSite; Q6P2M8; -.
DR   PRIDE; Q6P2M8; -.
DR   Ensembl; ENST00000340888; ENSP00000340586; ENSG00000130822.
DR   Ensembl; ENST00000370142; ENSP00000359161; ENSG00000130822.
DR   Ensembl; ENST00000370145; ENSP00000359164; ENSG00000130822.
DR   Ensembl; ENST00000370150; ENSP00000359169; ENSG00000130822.
DR   Ensembl; ENST00000393831; ENSP00000377417; ENSG00000130822.
DR   Ensembl; ENST00000447676; ENSP00000405950; ENSG00000130822.
DR   GeneID; 139728; -.
DR   KEGG; hsa:139728; -.
DR   UCSC; uc004fhz.2; human.
DR   UCSC; uc004fia.1; human.
DR   CTD; 139728; -.
DR   GeneCards; GC0XM141592; -.
DR   H-InvDB; HIX0017133; -.
DR   HGNC; HGNC:13415; PNCK.
DR   HPA; HPA007458; -.
DR   MIM; 300680; gene.
DR   neXtProt; NX_Q6P2M8; -.
DR   eggNOG; prNOG14938; -.
DR   GeneTree; ENSGT00600000084207; -.
DR   OMA; ALDKNIL; -.
DR   OrthoDB; EOG4T4CVW; -.
DR   PhylomeDB; Q6P2M8; -.
DR   NextBio; 84022; -.
DR   ArrayExpress; Q6P2M8; -.
DR   Bgee; Q6P2M8; -.
DR   CleanEx; HS_PNCK; -.
DR   Genevestigator; Q6P2M8; -.
DR   GermOnline; ENSG00000130822; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
DR   InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   PANTHER; PTHR24347; PTHR24347; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; HSX.PE2782; -.
KW   ENSG000001308221755old_1320000031; ENSP000003405867901old_1320000031;
KW   C9J2B9_HUMAN; C9JB09_HUMAN; C9JEC5_HUMAN; C9JJ18_HUMAN; D3DWU7_HUMAN;
KW   BC064422; CH471172; CR611192; U52111;
KW   Alternative splicing; ATP-binding; Calcium; Calmodulin-binding;
KW   Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Polymorphism; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   343 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA LRGKEALVEN
     EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV
     LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA
     PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS
     ESAKDFIRHL LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA
     FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
//

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